Raman spectroscopy and regenerative medicine: a review

Abstract The field of regenerative medicine spans a wide area of the biomedical landscape—from single cell culture in laboratories to human whole-organ transplantation. To ensure that research is transferrable from bench to bedside, it is critical that we are able to assess regenerative processes in...

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Autores principales:	Katherine J. I. Ember, Marieke A. Hoeve, Sarah L. McAughtrie, Mads S. Bergholt, Benjamin J. Dwyer, Molly M. Stevens, Karen Faulds, Stuart J. Forbes, Colin J. Campbell
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/460bb0d1f8614f40bf18cc579bab5422
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spelling	oai:doaj.org-article:460bb0d1f8614f40bf18cc579bab54222021-12-02T14:18:30ZRaman spectroscopy and regenerative medicine: a review10.1038/s41536-017-0014-32057-3995https://doaj.org/article/460bb0d1f8614f40bf18cc579bab54222017-05-01T00:00:00Zhttps://doi.org/10.1038/s41536-017-0014-3https://doaj.org/toc/2057-3995Abstract The field of regenerative medicine spans a wide area of the biomedical landscape—from single cell culture in laboratories to human whole-organ transplantation. To ensure that research is transferrable from bench to bedside, it is critical that we are able to assess regenerative processes in cells, tissues, organs and patients at a biochemical level. Regeneration relies on a large number of biological factors, which can be perturbed using conventional bioanalytical techniques. A versatile, non-invasive, non-destructive technique for biochemical analysis would be invaluable for the study of regeneration; and Raman spectroscopy is a potential solution. Raman spectroscopy is an analytical method by which chemical data are obtained through the inelastic scattering of light. Since its discovery in the 1920s, physicists and chemists have used Raman scattering to investigate the chemical composition of a vast range of both liquid and solid materials. However, only in the last two decades has this form of spectroscopy been employed in biomedical research. Particularly relevant to regenerative medicine are recent studies illustrating its ability to characterise and discriminate between healthy and disease states in cells, tissue biopsies and in patients. This review will briefly outline the principles behind Raman spectroscopy and its variants, describe key examples of its applications to biomedicine, and consider areas of regenerative medicine that would benefit from this non-invasive bioanalytical tool.Katherine J. I. EmberMarieke A. HoeveSarah L. McAughtrieMads S. BergholtBenjamin J. DwyerMolly M. StevensKaren FauldsStuart J. ForbesColin J. CampbellNature PortfolioarticleMedicineRENnpj Regenerative Medicine, Vol 2, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Katherine J. I. Ember Marieke A. Hoeve Sarah L. McAughtrie Mads S. Bergholt Benjamin J. Dwyer Molly M. Stevens Karen Faulds Stuart J. Forbes Colin J. Campbell Raman spectroscopy and regenerative medicine: a review
description	Abstract The field of regenerative medicine spans a wide area of the biomedical landscape—from single cell culture in laboratories to human whole-organ transplantation. To ensure that research is transferrable from bench to bedside, it is critical that we are able to assess regenerative processes in cells, tissues, organs and patients at a biochemical level. Regeneration relies on a large number of biological factors, which can be perturbed using conventional bioanalytical techniques. A versatile, non-invasive, non-destructive technique for biochemical analysis would be invaluable for the study of regeneration; and Raman spectroscopy is a potential solution. Raman spectroscopy is an analytical method by which chemical data are obtained through the inelastic scattering of light. Since its discovery in the 1920s, physicists and chemists have used Raman scattering to investigate the chemical composition of a vast range of both liquid and solid materials. However, only in the last two decades has this form of spectroscopy been employed in biomedical research. Particularly relevant to regenerative medicine are recent studies illustrating its ability to characterise and discriminate between healthy and disease states in cells, tissue biopsies and in patients. This review will briefly outline the principles behind Raman spectroscopy and its variants, describe key examples of its applications to biomedicine, and consider areas of regenerative medicine that would benefit from this non-invasive bioanalytical tool.
format	article
author	Katherine J. I. Ember Marieke A. Hoeve Sarah L. McAughtrie Mads S. Bergholt Benjamin J. Dwyer Molly M. Stevens Karen Faulds Stuart J. Forbes Colin J. Campbell
author_facet	Katherine J. I. Ember Marieke A. Hoeve Sarah L. McAughtrie Mads S. Bergholt Benjamin J. Dwyer Molly M. Stevens Karen Faulds Stuart J. Forbes Colin J. Campbell
author_sort	Katherine J. I. Ember
title	Raman spectroscopy and regenerative medicine: a review
title_short	Raman spectroscopy and regenerative medicine: a review
title_full	Raman spectroscopy and regenerative medicine: a review
title_fullStr	Raman spectroscopy and regenerative medicine: a review
title_full_unstemmed	Raman spectroscopy and regenerative medicine: a review
title_sort	raman spectroscopy and regenerative medicine: a review
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/460bb0d1f8614f40bf18cc579bab5422
work_keys_str_mv	AT katherinejiember ramanspectroscopyandregenerativemedicineareview AT mariekeahoeve ramanspectroscopyandregenerativemedicineareview AT sarahlmcaughtrie ramanspectroscopyandregenerativemedicineareview AT madssbergholt ramanspectroscopyandregenerativemedicineareview AT benjaminjdwyer ramanspectroscopyandregenerativemedicineareview AT mollymstevens ramanspectroscopyandregenerativemedicineareview AT karenfaulds ramanspectroscopyandregenerativemedicineareview AT stuartjforbes ramanspectroscopyandregenerativemedicineareview AT colinjcampbell ramanspectroscopyandregenerativemedicineareview
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Raman spectroscopy and regenerative medicine: a review

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