Topological progression in proliferating epithelia is driven by a unique variation in polygon distribution.

Morphogenesis is consequence of lots of small coordinated variations that occur during development. In proliferating stages, tissue growth is coupled to changes in shape and organization. A number of studies have analyzed the topological properties of proliferating epithelia using the Drosophila win...

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Autores principales:	Daniel Sánchez-Gutiérrez, Aurora Sáez, Alberto Pascual, Luis M Escudero
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/460eb5a720f44e69b1791683745522ff
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spelling	oai:doaj.org-article:460eb5a720f44e69b1791683745522ff2021-11-18T08:48:19ZTopological progression in proliferating epithelia is driven by a unique variation in polygon distribution.1932-620310.1371/journal.pone.0079227https://doaj.org/article/460eb5a720f44e69b1791683745522ff2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24223910/?tool=EBIhttps://doaj.org/toc/1932-6203Morphogenesis is consequence of lots of small coordinated variations that occur during development. In proliferating stages, tissue growth is coupled to changes in shape and organization. A number of studies have analyzed the topological properties of proliferating epithelia using the Drosophila wing disc as a model. These works are based in the existence of a fixed distribution of these epithelial cells according to their number of sides. Cell division, cell rearrangements or a combination of both mechanisms have been proposed to be responsible for this polygonal assembling. Here, we have used different system biology methods to compare images from two close proliferative stages that present high morphological similarity. This approach enables us to search for traces of epithelial organization. First, we show that geometrical and network characteristics of individual cells are mainly dependent on their number of sides. Second, we find a significant divergence between the distribution of polygons in epithelia from mid-third instar larva versus early prepupa. We show that this alteration propagates into changes in epithelial organization. Remarkably, only the variation in polygon distribution driven by morphogenesis leads to progression in epithelial organization. In addition, we identify the relevant features that characterize these rearrangements. Our results reveal signs of epithelial homogenization during the growing phase, before the planar cell polarity pathway leads to the hexagonal packing of the epithelium during pupal stages.Daniel Sánchez-GutiérrezAurora SáezAlberto PascualLuis M EscuderoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e79227 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Daniel Sánchez-Gutiérrez Aurora Sáez Alberto Pascual Luis M Escudero Topological progression in proliferating epithelia is driven by a unique variation in polygon distribution.
description	Morphogenesis is consequence of lots of small coordinated variations that occur during development. In proliferating stages, tissue growth is coupled to changes in shape and organization. A number of studies have analyzed the topological properties of proliferating epithelia using the Drosophila wing disc as a model. These works are based in the existence of a fixed distribution of these epithelial cells according to their number of sides. Cell division, cell rearrangements or a combination of both mechanisms have been proposed to be responsible for this polygonal assembling. Here, we have used different system biology methods to compare images from two close proliferative stages that present high morphological similarity. This approach enables us to search for traces of epithelial organization. First, we show that geometrical and network characteristics of individual cells are mainly dependent on their number of sides. Second, we find a significant divergence between the distribution of polygons in epithelia from mid-third instar larva versus early prepupa. We show that this alteration propagates into changes in epithelial organization. Remarkably, only the variation in polygon distribution driven by morphogenesis leads to progression in epithelial organization. In addition, we identify the relevant features that characterize these rearrangements. Our results reveal signs of epithelial homogenization during the growing phase, before the planar cell polarity pathway leads to the hexagonal packing of the epithelium during pupal stages.
format	article
author	Daniel Sánchez-Gutiérrez Aurora Sáez Alberto Pascual Luis M Escudero
author_facet	Daniel Sánchez-Gutiérrez Aurora Sáez Alberto Pascual Luis M Escudero
author_sort	Daniel Sánchez-Gutiérrez
title	Topological progression in proliferating epithelia is driven by a unique variation in polygon distribution.
title_short	Topological progression in proliferating epithelia is driven by a unique variation in polygon distribution.
title_full	Topological progression in proliferating epithelia is driven by a unique variation in polygon distribution.
title_fullStr	Topological progression in proliferating epithelia is driven by a unique variation in polygon distribution.
title_full_unstemmed	Topological progression in proliferating epithelia is driven by a unique variation in polygon distribution.
title_sort	topological progression in proliferating epithelia is driven by a unique variation in polygon distribution.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/460eb5a720f44e69b1791683745522ff
work_keys_str_mv	AT danielsanchezgutierrez topologicalprogressioninproliferatingepitheliaisdrivenbyauniquevariationinpolygondistribution AT aurorasaez topologicalprogressioninproliferatingepitheliaisdrivenbyauniquevariationinpolygondistribution AT albertopascual topologicalprogressioninproliferatingepitheliaisdrivenbyauniquevariationinpolygondistribution AT luismescudero topologicalprogressioninproliferatingepitheliaisdrivenbyauniquevariationinpolygondistribution
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Topological progression in proliferating epithelia is driven by a unique variation in polygon distribution.

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