Colony stimulating factor-1 in saliva in relation to age, smoking, and oral and systemic diseases

Abstract Colony stimulating factor (CSF)-1 is a growth factor that stimulates the survival, proliferation and differentiation of mononuclear phagocytes, which has been implicated in several inflammatory diseases. This study evaluated the possible influence of age, sex, smoking, periodontitis, caries...

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Autores principales:	Ronaldo Lira-Junior, Sigvard Åkerman, Anders Gustafsson, Björn Klinge, Elisabeth A. Boström
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/461345dd6f094d208ebd5c8cf3ad3854
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spelling	oai:doaj.org-article:461345dd6f094d208ebd5c8cf3ad38542021-12-02T16:08:20ZColony stimulating factor-1 in saliva in relation to age, smoking, and oral and systemic diseases10.1038/s41598-017-07698-42045-2322https://doaj.org/article/461345dd6f094d208ebd5c8cf3ad38542017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07698-4https://doaj.org/toc/2045-2322Abstract Colony stimulating factor (CSF)-1 is a growth factor that stimulates the survival, proliferation and differentiation of mononuclear phagocytes, which has been implicated in several inflammatory diseases. This study evaluated the possible influence of age, sex, smoking, periodontitis, caries, and several systemic conditions on salivary levels of CSF-1. Four-hundred and forty-one individuals were enrolled in this study. All participants answered a health questionnaire and underwent a comprehensive oral examination. Stimulated saliva was collected and CSF-1 levels were analysed by enzyme-linked immunosorbent assay. Salivary levels of CSF-1 were significantly increased in participants over 64 years old and in non-smoking individuals, whereas no difference was observed between men and women. Individuals having periodontitis and manifest caries had significantly higher levels of CSF-1. Participants with muscle and joint disease exhibited increased CSF-1 levels as compared to those without. Age, smoking, percentage of pockets ≥4 mm, number of manifest caries lesions, and presence of tumor were associated with CSF-1 levels. Salivary levels of CSF-1 are associated with age, smoking, periodontitis, manifest caries, and the presence of muscle and joint diseases and tumors. CSF-1 might be a promising biomarker candidate in saliva of both local and systemic conditions that needs further investigation.Ronaldo Lira-JuniorSigvard ÅkermanAnders GustafssonBjörn KlingeElisabeth A. BoströmNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ronaldo Lira-Junior Sigvard Åkerman Anders Gustafsson Björn Klinge Elisabeth A. Boström Colony stimulating factor-1 in saliva in relation to age, smoking, and oral and systemic diseases
description	Abstract Colony stimulating factor (CSF)-1 is a growth factor that stimulates the survival, proliferation and differentiation of mononuclear phagocytes, which has been implicated in several inflammatory diseases. This study evaluated the possible influence of age, sex, smoking, periodontitis, caries, and several systemic conditions on salivary levels of CSF-1. Four-hundred and forty-one individuals were enrolled in this study. All participants answered a health questionnaire and underwent a comprehensive oral examination. Stimulated saliva was collected and CSF-1 levels were analysed by enzyme-linked immunosorbent assay. Salivary levels of CSF-1 were significantly increased in participants over 64 years old and in non-smoking individuals, whereas no difference was observed between men and women. Individuals having periodontitis and manifest caries had significantly higher levels of CSF-1. Participants with muscle and joint disease exhibited increased CSF-1 levels as compared to those without. Age, smoking, percentage of pockets ≥4 mm, number of manifest caries lesions, and presence of tumor were associated with CSF-1 levels. Salivary levels of CSF-1 are associated with age, smoking, periodontitis, manifest caries, and the presence of muscle and joint diseases and tumors. CSF-1 might be a promising biomarker candidate in saliva of both local and systemic conditions that needs further investigation.
format	article
author	Ronaldo Lira-Junior Sigvard Åkerman Anders Gustafsson Björn Klinge Elisabeth A. Boström
author_facet	Ronaldo Lira-Junior Sigvard Åkerman Anders Gustafsson Björn Klinge Elisabeth A. Boström
author_sort	Ronaldo Lira-Junior
title	Colony stimulating factor-1 in saliva in relation to age, smoking, and oral and systemic diseases
title_short	Colony stimulating factor-1 in saliva in relation to age, smoking, and oral and systemic diseases
title_full	Colony stimulating factor-1 in saliva in relation to age, smoking, and oral and systemic diseases
title_fullStr	Colony stimulating factor-1 in saliva in relation to age, smoking, and oral and systemic diseases
title_full_unstemmed	Colony stimulating factor-1 in saliva in relation to age, smoking, and oral and systemic diseases
title_sort	colony stimulating factor-1 in saliva in relation to age, smoking, and oral and systemic diseases
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/461345dd6f094d208ebd5c8cf3ad3854
work_keys_str_mv	AT ronaldolirajunior colonystimulatingfactor1insalivainrelationtoagesmokingandoralandsystemicdiseases AT sigvardakerman colonystimulatingfactor1insalivainrelationtoagesmokingandoralandsystemicdiseases AT andersgustafsson colonystimulatingfactor1insalivainrelationtoagesmokingandoralandsystemicdiseases AT bjornklinge colonystimulatingfactor1insalivainrelationtoagesmokingandoralandsystemicdiseases AT elisabethabostrom colonystimulatingfactor1insalivainrelationtoagesmokingandoralandsystemicdiseases
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Colony stimulating factor-1 in saliva in relation to age, smoking, and oral and systemic diseases

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