Regional grey matter structure differences between transsexuals and healthy controls--a voxel based morphometry study.

Gender identity disorder (GID) refers to transsexual individuals who feel that their assigned biological gender is incongruent with their gender identity and this cannot be explained by any physical intersex condition. There is growing scientific interest in the last decades in studying the neuroana...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lajos Simon, Lajos R Kozák, Viktória Simon, Pál Czobor, Zsolt Unoka, Ádám Szabó, Gábor Csukly
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/46143ca56d944dfe9251531579d0b3d5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:46143ca56d944dfe9251531579d0b3d5
record_format	dspace
spelling	oai:doaj.org-article:46143ca56d944dfe9251531579d0b3d52021-11-18T08:39:29ZRegional grey matter structure differences between transsexuals and healthy controls--a voxel based morphometry study.1932-620310.1371/journal.pone.0083947https://doaj.org/article/46143ca56d944dfe9251531579d0b3d52013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24391851/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Gender identity disorder (GID) refers to transsexual individuals who feel that their assigned biological gender is incongruent with their gender identity and this cannot be explained by any physical intersex condition. There is growing scientific interest in the last decades in studying the neuroanatomy and brain functions of transsexual individuals to better understand both the neuroanatomical features of transsexualism and the background of gender identity. So far, results are inconclusive but in general, transsexualism has been associated with a distinct neuroanatomical pattern. Studies mainly focused on male to female (MTF) transsexuals and there is scarcity of data acquired on female to male (FTM) transsexuals. Thus, our aim was to analyze structural MRI data with voxel based morphometry (VBM) obtained from both FTM and MTF transsexuals (n = 17) and compare them to the data of 18 age matched healthy control subjects (both males and females). We found differences in the regional grey matter (GM) structure of transsexual compared with control subjects, independent from their biological gender, in the cerebellum, the left angular gyrus and in the left inferior parietal lobule. Additionally, our findings showed that in several brain areas, regarding their GM volume, transsexual subjects did not differ significantly from controls sharing their gender identity but were different from those sharing their biological gender (areas in the left and right precentral gyri, the left postcentral gyrus, the left posterior cingulate, precuneus and calcarinus, the right cuneus, the right fusiform, lingual, middle and inferior occipital, and inferior temporal gyri). These results support the notion that structural brain differences exist between transsexual and healthy control subjects and that majority of these structural differences are dependent on the biological gender.Lajos SimonLajos R KozákViktória SimonPál CzoborZsolt UnokaÁdám SzabóGábor CsuklyPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 12, p e83947 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lajos Simon Lajos R Kozák Viktória Simon Pál Czobor Zsolt Unoka Ádám Szabó Gábor Csukly Regional grey matter structure differences between transsexuals and healthy controls--a voxel based morphometry study.
description	Gender identity disorder (GID) refers to transsexual individuals who feel that their assigned biological gender is incongruent with their gender identity and this cannot be explained by any physical intersex condition. There is growing scientific interest in the last decades in studying the neuroanatomy and brain functions of transsexual individuals to better understand both the neuroanatomical features of transsexualism and the background of gender identity. So far, results are inconclusive but in general, transsexualism has been associated with a distinct neuroanatomical pattern. Studies mainly focused on male to female (MTF) transsexuals and there is scarcity of data acquired on female to male (FTM) transsexuals. Thus, our aim was to analyze structural MRI data with voxel based morphometry (VBM) obtained from both FTM and MTF transsexuals (n = 17) and compare them to the data of 18 age matched healthy control subjects (both males and females). We found differences in the regional grey matter (GM) structure of transsexual compared with control subjects, independent from their biological gender, in the cerebellum, the left angular gyrus and in the left inferior parietal lobule. Additionally, our findings showed that in several brain areas, regarding their GM volume, transsexual subjects did not differ significantly from controls sharing their gender identity but were different from those sharing their biological gender (areas in the left and right precentral gyri, the left postcentral gyrus, the left posterior cingulate, precuneus and calcarinus, the right cuneus, the right fusiform, lingual, middle and inferior occipital, and inferior temporal gyri). These results support the notion that structural brain differences exist between transsexual and healthy control subjects and that majority of these structural differences are dependent on the biological gender.
format	article
author	Lajos Simon Lajos R Kozák Viktória Simon Pál Czobor Zsolt Unoka Ádám Szabó Gábor Csukly
author_facet	Lajos Simon Lajos R Kozák Viktória Simon Pál Czobor Zsolt Unoka Ádám Szabó Gábor Csukly
author_sort	Lajos Simon
title	Regional grey matter structure differences between transsexuals and healthy controls--a voxel based morphometry study.
title_short	Regional grey matter structure differences between transsexuals and healthy controls--a voxel based morphometry study.
title_full	Regional grey matter structure differences between transsexuals and healthy controls--a voxel based morphometry study.
title_fullStr	Regional grey matter structure differences between transsexuals and healthy controls--a voxel based morphometry study.
title_full_unstemmed	Regional grey matter structure differences between transsexuals and healthy controls--a voxel based morphometry study.
title_sort	regional grey matter structure differences between transsexuals and healthy controls--a voxel based morphometry study.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/46143ca56d944dfe9251531579d0b3d5
work_keys_str_mv	AT lajossimon regionalgreymatterstructuredifferencesbetweentranssexualsandhealthycontrolsavoxelbasedmorphometrystudy AT lajosrkozak regionalgreymatterstructuredifferencesbetweentranssexualsandhealthycontrolsavoxelbasedmorphometrystudy AT viktoriasimon regionalgreymatterstructuredifferencesbetweentranssexualsandhealthycontrolsavoxelbasedmorphometrystudy AT palczobor regionalgreymatterstructuredifferencesbetweentranssexualsandhealthycontrolsavoxelbasedmorphometrystudy AT zsoltunoka regionalgreymatterstructuredifferencesbetweentranssexualsandhealthycontrolsavoxelbasedmorphometrystudy AT adamszabo regionalgreymatterstructuredifferencesbetweentranssexualsandhealthycontrolsavoxelbasedmorphometrystudy AT gaborcsukly regionalgreymatterstructuredifferencesbetweentranssexualsandhealthycontrolsavoxelbasedmorphometrystudy
_version_	1718421497377193984

Regional grey matter structure differences between transsexuals and healthy controls--a voxel based morphometry study.

Ejemplares similares