Virgin olive oil blended polyurethane micro/nanofibers ornamented with copper oxide nanocrystals for biomedical applications

Touseef Amna,1 M Shamshi Hassan,2 Jieun Yang,1 Myung-Seob Khil,2 Ki-Duk Song,3 Jae-Don Oh,3 Inho Hwang1 1Department of Animal Sciences and Biotechnology, 2Department of Organic Materials and Fiber Engineering, Chonbuk National University, Jeonju, South Korea; 3Genomic Informatics Center, Hankyong N...

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Autores principales:	Amna T, Hassan MS, Yang J, Khil MS, Song KD, Oh JD, Hwang I
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/4616ca7e1c264d25aab6cd83730905ce
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spelling	oai:doaj.org-article:4616ca7e1c264d25aab6cd83730905ce2021-12-02T08:07:46ZVirgin olive oil blended polyurethane micro/nanofibers ornamented with copper oxide nanocrystals for biomedical applications1178-2013https://doaj.org/article/4616ca7e1c264d25aab6cd83730905ce2014-02-01T00:00:00Zhttp://www.dovepress.com/virgin-olive-oil-blended-polyurethane-micronanofibers-ornamented-with--a15810https://doaj.org/toc/1178-2013 Touseef Amna,1 M Shamshi Hassan,2 Jieun Yang,1 Myung-Seob Khil,2 Ki-Duk Song,3 Jae-Don Oh,3 Inho Hwang1 1Department of Animal Sciences and Biotechnology, 2Department of Organic Materials and Fiber Engineering, Chonbuk National University, Jeonju, South Korea; 3Genomic Informatics Center, Hankyong National University, Anseong, South Korea Abstract: Recently, substantial interest has been generated in using electrospun biomimetic nanofibers of hybrids, particularly organic/inorganic, to engineer different tissues. The present work, for the first time, introduced a unique natural and synthetic hybrid micronanofiber wound dressing, composed of virgin olive oil/copper oxide nanocrystals and polyurethane (PU), developed via facile electrospinning. The as-spun organic/inorganic hybrid micronanofibers were characterized by scanning electron microscopy (SEM), energy dispersive X-ray analysis, X-ray diffraction, electron probe microanalysis, and transmission electron microscopy. The interaction of cells with scaffold was studied by culturing NIH 3T3 fibroblasts on an as-spun hybrid micronanofibrous mat, and viability, proliferation, and growth were assessed. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay results and SEM observation showed that the hybrid micronanofibrous scaffold was noncytotoxic to fibroblast cell culture and was found to benefit cell attachment and proliferation. Hence our results suggest the potential utilization of as-spun micronanoscaffolds for tissue engineering. Copper oxide–olive oil/PU wound dressing may exert its positive beneficial effects at every stage during wound-healing progression, and these micronanofibers may serve diverse biomedical applications, such as tissue regeneration, damaged skin treatment, wound healing applications, etc. Conclusively, the fabricated olive oil–copper oxide/PU micronanofibers combine the benefits of virgin olive oil and copper oxide, and therefore hold great promise for biomedical applications in the near future. Keywords: micronanofibers, copper oxide, wound healing, polyurethane, olive oilAmna THassan MSYang JKhil MSSong KDOh JDHwang IDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 891-898 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Amna T Hassan MS Yang J Khil MS Song KD Oh JD Hwang I Virgin olive oil blended polyurethane micro/nanofibers ornamented with copper oxide nanocrystals for biomedical applications
description	Touseef Amna,1 M Shamshi Hassan,2 Jieun Yang,1 Myung-Seob Khil,2 Ki-Duk Song,3 Jae-Don Oh,3 Inho Hwang1 1Department of Animal Sciences and Biotechnology, 2Department of Organic Materials and Fiber Engineering, Chonbuk National University, Jeonju, South Korea; 3Genomic Informatics Center, Hankyong National University, Anseong, South Korea Abstract: Recently, substantial interest has been generated in using electrospun biomimetic nanofibers of hybrids, particularly organic/inorganic, to engineer different tissues. The present work, for the first time, introduced a unique natural and synthetic hybrid micronanofiber wound dressing, composed of virgin olive oil/copper oxide nanocrystals and polyurethane (PU), developed via facile electrospinning. The as-spun organic/inorganic hybrid micronanofibers were characterized by scanning electron microscopy (SEM), energy dispersive X-ray analysis, X-ray diffraction, electron probe microanalysis, and transmission electron microscopy. The interaction of cells with scaffold was studied by culturing NIH 3T3 fibroblasts on an as-spun hybrid micronanofibrous mat, and viability, proliferation, and growth were assessed. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay results and SEM observation showed that the hybrid micronanofibrous scaffold was noncytotoxic to fibroblast cell culture and was found to benefit cell attachment and proliferation. Hence our results suggest the potential utilization of as-spun micronanoscaffolds for tissue engineering. Copper oxide–olive oil/PU wound dressing may exert its positive beneficial effects at every stage during wound-healing progression, and these micronanofibers may serve diverse biomedical applications, such as tissue regeneration, damaged skin treatment, wound healing applications, etc. Conclusively, the fabricated olive oil–copper oxide/PU micronanofibers combine the benefits of virgin olive oil and copper oxide, and therefore hold great promise for biomedical applications in the near future. Keywords: micronanofibers, copper oxide, wound healing, polyurethane, olive oil
format	article
author	Amna T Hassan MS Yang J Khil MS Song KD Oh JD Hwang I
author_facet	Amna T Hassan MS Yang J Khil MS Song KD Oh JD Hwang I
author_sort	Amna T
title	Virgin olive oil blended polyurethane micro/nanofibers ornamented with copper oxide nanocrystals for biomedical applications
title_short	Virgin olive oil blended polyurethane micro/nanofibers ornamented with copper oxide nanocrystals for biomedical applications
title_full	Virgin olive oil blended polyurethane micro/nanofibers ornamented with copper oxide nanocrystals for biomedical applications
title_fullStr	Virgin olive oil blended polyurethane micro/nanofibers ornamented with copper oxide nanocrystals for biomedical applications
title_full_unstemmed	Virgin olive oil blended polyurethane micro/nanofibers ornamented with copper oxide nanocrystals for biomedical applications
title_sort	virgin olive oil blended polyurethane micro/nanofibers ornamented with copper oxide nanocrystals for biomedical applications
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/4616ca7e1c264d25aab6cd83730905ce
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Virgin olive oil blended polyurethane micro/nanofibers ornamented with copper oxide nanocrystals for biomedical applications

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