Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis

Enhanced glycolysis in cancer cells has been associated with protection from DNA damage. Here the authors show that DNA damaging signals induce acetylation of PFKFB3 at lysine K472 and promote its cytosolic accumulation, which enhances glycolysis, resulting in protection from cisplatin-induced cell...

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Autores principales:	Fu-Long Li, Jin-Ping Liu, Ruo-Xuan Bao, GuoQuan Yan, Xu Feng, Yan-Ping Xu, Yi-Ping Sun, Weili Yan, Zhi-Qiang Ling, Yue Xiong, Kun-Liang Guan, Hai-Xin Yuan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/461b17d4756348ec8fa51f6eb566a6ce
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spelling	oai:doaj.org-article:461b17d4756348ec8fa51f6eb566a6ce2021-12-02T15:34:05ZAcetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis10.1038/s41467-018-02950-52041-1723https://doaj.org/article/461b17d4756348ec8fa51f6eb566a6ce2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-02950-5https://doaj.org/toc/2041-1723Enhanced glycolysis in cancer cells has been associated with protection from DNA damage. Here the authors show that DNA damaging signals induce acetylation of PFKFB3 at lysine K472 and promote its cytosolic accumulation, which enhances glycolysis, resulting in protection from cisplatin-induced cell death.Fu-Long LiJin-Ping LiuRuo-Xuan BaoGuoQuan YanXu FengYan-Ping XuYi-Ping SunWeili YanZhi-Qiang LingYue XiongKun-Liang GuanHai-Xin YuanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fu-Long Li Jin-Ping Liu Ruo-Xuan Bao GuoQuan Yan Xu Feng Yan-Ping Xu Yi-Ping Sun Weili Yan Zhi-Qiang Ling Yue Xiong Kun-Liang Guan Hai-Xin Yuan Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis
description	Enhanced glycolysis in cancer cells has been associated with protection from DNA damage. Here the authors show that DNA damaging signals induce acetylation of PFKFB3 at lysine K472 and promote its cytosolic accumulation, which enhances glycolysis, resulting in protection from cisplatin-induced cell death.
format	article
author	Fu-Long Li Jin-Ping Liu Ruo-Xuan Bao GuoQuan Yan Xu Feng Yan-Ping Xu Yi-Ping Sun Weili Yan Zhi-Qiang Ling Yue Xiong Kun-Liang Guan Hai-Xin Yuan
author_facet	Fu-Long Li Jin-Ping Liu Ruo-Xuan Bao GuoQuan Yan Xu Feng Yan-Ping Xu Yi-Ping Sun Weili Yan Zhi-Qiang Ling Yue Xiong Kun-Liang Guan Hai-Xin Yuan
author_sort	Fu-Long Li
title	Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis
title_short	Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis
title_full	Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis
title_fullStr	Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis
title_full_unstemmed	Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis
title_sort	acetylation accumulates pfkfb3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/461b17d4756348ec8fa51f6eb566a6ce
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Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis

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