Low-frequency exercise training improves cardiovascular fitness and strength during treatment for breast cancer: a single-arm intervention study

Abstract Aerobic and resistance exercise during and after cancer treatment are important for health-related outcomes, however treatment-specific barriers may inhibit adherence. We explored the effect of lower-frequency exercise training on fitness, body composition, and metabolic markers (i.e. gluco...

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Autores principales:	Kirsten E. Bell, Amanda G. Pfeiffer, Schuyler Schmidt, Lisa Bos, Caryl Russell, Tyler Barnes, Katie M. Di Sebastiano, Egor Avrutin, Marielle Gibson, Joel A. Dubin, Marina Mourtzakis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/461b3a486af7400dbe04c8eb732b205a
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spelling	oai:doaj.org-article:461b3a486af7400dbe04c8eb732b205a2021-11-28T12:19:18ZLow-frequency exercise training improves cardiovascular fitness and strength during treatment for breast cancer: a single-arm intervention study10.1038/s41598-021-01962-42045-2322https://doaj.org/article/461b3a486af7400dbe04c8eb732b205a2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01962-4https://doaj.org/toc/2045-2322Abstract Aerobic and resistance exercise during and after cancer treatment are important for health-related outcomes, however treatment-specific barriers may inhibit adherence. We explored the effect of lower-frequency exercise training on fitness, body composition, and metabolic markers (i.e. glucose and lipids) in a group of recently diagnosed breast cancer patients. Fifty-two females ≥ 18 years with stage I–IIIB breast cancer were instructed to attend 2 cardiovascular and strength training sessions/week over 12 weeks, but program length was expanded as needed to accommodate missed sessions. Pre- and post-intervention, we measured: (1) cardiovascular fitness, (2) isometric strength, (3) body composition (dual-energy X-ray absorptiometry), and (4) fasting glucose, insulin, c-peptide, and lipids. Pre-intervention, participants were 53 ± 10 years old (mean ± SD) and overweight (BMI: 27.5 ± 5.4 kg m−2, 40.1 ± 6.5% body fat). Forty participants completed the program over a median 20 weeks (range: 13–32 weeks, median frequency: 1.2 sessions/week), over which predicted VO2peak improved by 7% (2.2[0.1–4.4] mL/kg/min) (delta[95% CI]), and strength increased by 7–9% (right arm: 2.3[0.1–4.5] N m; right leg: 7.9[2.1–13.7] N m; left leg: 7.8[1.9–13.7] N m). Body composition and metabolic markers were unchanged. An exercise frequency of 1.2 sessions/week stimulated significant improvements in fitness, and may represent a practical target for patients during active treatment.Kirsten E. BellAmanda G. PfeifferSchuyler SchmidtLisa BosCaryl RussellTyler BarnesKatie M. Di SebastianoEgor AvrutinMarielle GibsonJoel A. DubinMarina MourtzakisNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kirsten E. Bell Amanda G. Pfeiffer Schuyler Schmidt Lisa Bos Caryl Russell Tyler Barnes Katie M. Di Sebastiano Egor Avrutin Marielle Gibson Joel A. Dubin Marina Mourtzakis Low-frequency exercise training improves cardiovascular fitness and strength during treatment for breast cancer: a single-arm intervention study
description	Abstract Aerobic and resistance exercise during and after cancer treatment are important for health-related outcomes, however treatment-specific barriers may inhibit adherence. We explored the effect of lower-frequency exercise training on fitness, body composition, and metabolic markers (i.e. glucose and lipids) in a group of recently diagnosed breast cancer patients. Fifty-two females ≥ 18 years with stage I–IIIB breast cancer were instructed to attend 2 cardiovascular and strength training sessions/week over 12 weeks, but program length was expanded as needed to accommodate missed sessions. Pre- and post-intervention, we measured: (1) cardiovascular fitness, (2) isometric strength, (3) body composition (dual-energy X-ray absorptiometry), and (4) fasting glucose, insulin, c-peptide, and lipids. Pre-intervention, participants were 53 ± 10 years old (mean ± SD) and overweight (BMI: 27.5 ± 5.4 kg m−2, 40.1 ± 6.5% body fat). Forty participants completed the program over a median 20 weeks (range: 13–32 weeks, median frequency: 1.2 sessions/week), over which predicted VO2peak improved by 7% (2.2[0.1–4.4] mL/kg/min) (delta[95% CI]), and strength increased by 7–9% (right arm: 2.3[0.1–4.5] N m; right leg: 7.9[2.1–13.7] N m; left leg: 7.8[1.9–13.7] N m). Body composition and metabolic markers were unchanged. An exercise frequency of 1.2 sessions/week stimulated significant improvements in fitness, and may represent a practical target for patients during active treatment.
format	article
author	Kirsten E. Bell Amanda G. Pfeiffer Schuyler Schmidt Lisa Bos Caryl Russell Tyler Barnes Katie M. Di Sebastiano Egor Avrutin Marielle Gibson Joel A. Dubin Marina Mourtzakis
author_facet	Kirsten E. Bell Amanda G. Pfeiffer Schuyler Schmidt Lisa Bos Caryl Russell Tyler Barnes Katie M. Di Sebastiano Egor Avrutin Marielle Gibson Joel A. Dubin Marina Mourtzakis
author_sort	Kirsten E. Bell
title	Low-frequency exercise training improves cardiovascular fitness and strength during treatment for breast cancer: a single-arm intervention study
title_short	Low-frequency exercise training improves cardiovascular fitness and strength during treatment for breast cancer: a single-arm intervention study
title_full	Low-frequency exercise training improves cardiovascular fitness and strength during treatment for breast cancer: a single-arm intervention study
title_fullStr	Low-frequency exercise training improves cardiovascular fitness and strength during treatment for breast cancer: a single-arm intervention study
title_full_unstemmed	Low-frequency exercise training improves cardiovascular fitness and strength during treatment for breast cancer: a single-arm intervention study
title_sort	low-frequency exercise training improves cardiovascular fitness and strength during treatment for breast cancer: a single-arm intervention study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/461b3a486af7400dbe04c8eb732b205a
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Low-frequency exercise training improves cardiovascular fitness and strength during treatment for breast cancer: a single-arm intervention study

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