Protein-induced satiation and the calcium-sensing receptor

Utkarsh Ojha Faculty of Medicine, Imperial College School of Medicine, Imperial College London, London, UK Abstract: Obesity is a major global health issue. High-protein diets have been shown to be associated with weight loss and satiety. The precise mechanism by which protein-rich diets promote wei...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autor principal:	Ojha U
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Amino acids calcium sensing receptor energy regulation obesity therapy L-cells Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/461c0f24c8f84ab590445c96cb876fb1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:461c0f24c8f84ab590445c96cb876fb1
record_format	dspace
spelling	oai:doaj.org-article:461c0f24c8f84ab590445c96cb876fb12021-12-02T07:21:21ZProtein-induced satiation and the calcium-sensing receptor1178-7007https://doaj.org/article/461c0f24c8f84ab590445c96cb876fb12018-03-01T00:00:00Zhttps://www.dovepress.com/protein-induced-satiation-and-the-calcium-sensing-receptor-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Utkarsh Ojha Faculty of Medicine, Imperial College School of Medicine, Imperial College London, London, UK Abstract: Obesity is a major global health issue. High-protein diets have been shown to be associated with weight loss and satiety. The precise mechanism by which protein-rich diets promote weight loss remains unclear. Evidence suggests amino acids, formed as a consequence of protein digestion, are sensed by specific receptors on L-cells in the gastrointestinal (GI) tract. These L-cells respond by secreting gut hormones that subsequently induce satiety. In recent years, the calcium-sensing receptor has been identified in several cells of the GI tract, including L-cells, and suggested to sense specific amino acids. This review evaluates the evidence for protein-rich diets in inducing weight loss and how the calcium-sensing receptor may be implicated in this phenomenon. Commandeering the mechanisms by which elements of a protein-rich diet suppress appetite may provide another successful avenue for developing anti-obesity drugs. Keywords: amino acids, energy regulation, obesity therapy, glucagon-like-peptide-1, peptide YYOjha UDove Medical PressarticleAmino acidscalcium sensing receptorenergy regulationobesity therapyL-cellsSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 11, Pp 45-51 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Amino acids calcium sensing receptor energy regulation obesity therapy L-cells Specialties of internal medicine RC581-951
spellingShingle	Amino acids calcium sensing receptor energy regulation obesity therapy L-cells Specialties of internal medicine RC581-951 Ojha U Protein-induced satiation and the calcium-sensing receptor
description	Utkarsh Ojha Faculty of Medicine, Imperial College School of Medicine, Imperial College London, London, UK Abstract: Obesity is a major global health issue. High-protein diets have been shown to be associated with weight loss and satiety. The precise mechanism by which protein-rich diets promote weight loss remains unclear. Evidence suggests amino acids, formed as a consequence of protein digestion, are sensed by specific receptors on L-cells in the gastrointestinal (GI) tract. These L-cells respond by secreting gut hormones that subsequently induce satiety. In recent years, the calcium-sensing receptor has been identified in several cells of the GI tract, including L-cells, and suggested to sense specific amino acids. This review evaluates the evidence for protein-rich diets in inducing weight loss and how the calcium-sensing receptor may be implicated in this phenomenon. Commandeering the mechanisms by which elements of a protein-rich diet suppress appetite may provide another successful avenue for developing anti-obesity drugs. Keywords: amino acids, energy regulation, obesity therapy, glucagon-like-peptide-1, peptide YY
format	article
author	Ojha U
author_facet	Ojha U
author_sort	Ojha U
title	Protein-induced satiation and the calcium-sensing receptor
title_short	Protein-induced satiation and the calcium-sensing receptor
title_full	Protein-induced satiation and the calcium-sensing receptor
title_fullStr	Protein-induced satiation and the calcium-sensing receptor
title_full_unstemmed	Protein-induced satiation and the calcium-sensing receptor
title_sort	protein-induced satiation and the calcium-sensing receptor
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/461c0f24c8f84ab590445c96cb876fb1
work_keys_str_mv	AT ojhau proteininducedsatiationandthecalciumsensingreceptor
_version_	1718399453709205504

Protein-induced satiation and the calcium-sensing receptor

Ejemplares similares