Abp1 promotes Arp2/3 complex-dependent actin nucleation and stabilizes branch junctions by antagonizing GMF

Abp1, a type II actin nucleation promoting factor, is a known component of branched actin networks but its mechanism remains poorly understood. Here, the authors find that Abp1 enhances Arp2/3-mediated actin branch formation, and blocks ‘debranching’ by GMF, making it a pro-branching factor.

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Autores principales:	Siyang Guo, Olga S. Sokolova, Johnson Chung, Shae Padrick, Jeff Gelles, Bruce L. Goode
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/461cdd4ab1814dbc9d5420598bd15668
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spelling	oai:doaj.org-article:461cdd4ab1814dbc9d5420598bd156682021-12-02T17:31:28ZAbp1 promotes Arp2/3 complex-dependent actin nucleation and stabilizes branch junctions by antagonizing GMF10.1038/s41467-018-05260-y2041-1723https://doaj.org/article/461cdd4ab1814dbc9d5420598bd156682018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05260-yhttps://doaj.org/toc/2041-1723Abp1, a type II actin nucleation promoting factor, is a known component of branched actin networks but its mechanism remains poorly understood. Here, the authors find that Abp1 enhances Arp2/3-mediated actin branch formation, and blocks ‘debranching’ by GMF, making it a pro-branching factor.Siyang GuoOlga S. SokolovaJohnson ChungShae PadrickJeff GellesBruce L. GoodeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Siyang Guo Olga S. Sokolova Johnson Chung Shae Padrick Jeff Gelles Bruce L. Goode Abp1 promotes Arp2/3 complex-dependent actin nucleation and stabilizes branch junctions by antagonizing GMF
description	Abp1, a type II actin nucleation promoting factor, is a known component of branched actin networks but its mechanism remains poorly understood. Here, the authors find that Abp1 enhances Arp2/3-mediated actin branch formation, and blocks ‘debranching’ by GMF, making it a pro-branching factor.
format	article
author	Siyang Guo Olga S. Sokolova Johnson Chung Shae Padrick Jeff Gelles Bruce L. Goode
author_facet	Siyang Guo Olga S. Sokolova Johnson Chung Shae Padrick Jeff Gelles Bruce L. Goode
author_sort	Siyang Guo
title	Abp1 promotes Arp2/3 complex-dependent actin nucleation and stabilizes branch junctions by antagonizing GMF
title_short	Abp1 promotes Arp2/3 complex-dependent actin nucleation and stabilizes branch junctions by antagonizing GMF
title_full	Abp1 promotes Arp2/3 complex-dependent actin nucleation and stabilizes branch junctions by antagonizing GMF
title_fullStr	Abp1 promotes Arp2/3 complex-dependent actin nucleation and stabilizes branch junctions by antagonizing GMF
title_full_unstemmed	Abp1 promotes Arp2/3 complex-dependent actin nucleation and stabilizes branch junctions by antagonizing GMF
title_sort	abp1 promotes arp2/3 complex-dependent actin nucleation and stabilizes branch junctions by antagonizing gmf
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/461cdd4ab1814dbc9d5420598bd15668
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Abp1 promotes Arp2/3 complex-dependent actin nucleation and stabilizes branch junctions by antagonizing GMF

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