AN IMMUNOTHERAPEUTIC CONCEPT OF MICROBIAL ANTIGEN APPLICATION IN ATOPY AND DISORDERS ASSOCIATED WITH FACULTATIVE MICROFLORA, AS EXEMPLIFIED BY A POLYCOMPONENT IMMUNOVAC VP4 VACCINE

Abstract. Immunomodulating drugs play an important role in therapy and prevention of numeous diseases associated with altered immune functions. Immunomodulators of bacterial origin are the most active ones, serving as a basis for design of therapeutic vaccines that are capable of stimulating antigen...

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Autores principales:	N. B. Egorova, E. A. Kurbatova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	facultative pathogens allergy immunotherapy Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/461e0f19242a49779167609565a360ca
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spelling	oai:doaj.org-article:461e0f19242a49779167609565a360ca2021-11-18T08:03:37ZAN IMMUNOTHERAPEUTIC CONCEPT OF MICROBIAL ANTIGEN APPLICATION IN ATOPY AND DISORDERS ASSOCIATED WITH FACULTATIVE MICROFLORA, AS EXEMPLIFIED BY A POLYCOMPONENT IMMUNOVAC VP4 VACCINE1563-06252313-741X10.15789/1563-0625-2008-1-13-20https://doaj.org/article/461e0f19242a49779167609565a360ca2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/72https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Immunomodulating drugs play an important role in therapy and prevention of numeous diseases associated with altered immune functions. Immunomodulators of bacterial origin are the most active ones, serving as a basis for design of therapeutic vaccines that are capable of stimulating antigen-specific response, along with nonspecific actions. The Immunovac VP4 poly-component vaccine is among such preparations, being a potent activator of innate immunity and showing protective activities against a number of facultative pathogens. In present review, the data are summarized that concern therapeutic effects of Immunovac VP4 in various disorders (lung abscess, chronic bronchitis, bronchial asthma, atopic dermatitis, pyodermia, herpes, acute respiratory infections). In all cases, high clinical effect was registered, i.e., decrease in number and severity of relapses, decreased dosage/number of medical drugs applied, prolongation of remission states, and transition to less severe clinical forms. The therapeutic effect is accompanied by sufficient positive dynamics of immunological parameters, e.g., phagocytic activity of macrophages, increase in lymphocytes bearing CD4, CD8, CD16, CD72, CD21 markers, enhanced IFNγ and IFNα production, correction of Ig synthesis, increased antibody titers and affinity. Analysis of data from strictly controlled studies performed in limited clinical samples, has shown a number of general regularities for common effects of microbial antigens in various disorders including allergic diseases.N. B. EgorovaE. A. KurbatovaSPb RAACIarticlefacultative pathogensallergyimmunotherapyImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 10, Iss 1, Pp 13-20 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	facultative pathogens allergy immunotherapy Immunologic diseases. Allergy RC581-607
spellingShingle	facultative pathogens allergy immunotherapy Immunologic diseases. Allergy RC581-607 N. B. Egorova E. A. Kurbatova AN IMMUNOTHERAPEUTIC CONCEPT OF MICROBIAL ANTIGEN APPLICATION IN ATOPY AND DISORDERS ASSOCIATED WITH FACULTATIVE MICROFLORA, AS EXEMPLIFIED BY A POLYCOMPONENT IMMUNOVAC VP4 VACCINE
description	Abstract. Immunomodulating drugs play an important role in therapy and prevention of numeous diseases associated with altered immune functions. Immunomodulators of bacterial origin are the most active ones, serving as a basis for design of therapeutic vaccines that are capable of stimulating antigen-specific response, along with nonspecific actions. The Immunovac VP4 poly-component vaccine is among such preparations, being a potent activator of innate immunity and showing protective activities against a number of facultative pathogens. In present review, the data are summarized that concern therapeutic effects of Immunovac VP4 in various disorders (lung abscess, chronic bronchitis, bronchial asthma, atopic dermatitis, pyodermia, herpes, acute respiratory infections). In all cases, high clinical effect was registered, i.e., decrease in number and severity of relapses, decreased dosage/number of medical drugs applied, prolongation of remission states, and transition to less severe clinical forms. The therapeutic effect is accompanied by sufficient positive dynamics of immunological parameters, e.g., phagocytic activity of macrophages, increase in lymphocytes bearing CD4, CD8, CD16, CD72, CD21 markers, enhanced IFNγ and IFNα production, correction of Ig synthesis, increased antibody titers and affinity. Analysis of data from strictly controlled studies performed in limited clinical samples, has shown a number of general regularities for common effects of microbial antigens in various disorders including allergic diseases.
format	article
author	N. B. Egorova E. A. Kurbatova
author_facet	N. B. Egorova E. A. Kurbatova
author_sort	N. B. Egorova
title	AN IMMUNOTHERAPEUTIC CONCEPT OF MICROBIAL ANTIGEN APPLICATION IN ATOPY AND DISORDERS ASSOCIATED WITH FACULTATIVE MICROFLORA, AS EXEMPLIFIED BY A POLYCOMPONENT IMMUNOVAC VP4 VACCINE
title_short	AN IMMUNOTHERAPEUTIC CONCEPT OF MICROBIAL ANTIGEN APPLICATION IN ATOPY AND DISORDERS ASSOCIATED WITH FACULTATIVE MICROFLORA, AS EXEMPLIFIED BY A POLYCOMPONENT IMMUNOVAC VP4 VACCINE
title_full	AN IMMUNOTHERAPEUTIC CONCEPT OF MICROBIAL ANTIGEN APPLICATION IN ATOPY AND DISORDERS ASSOCIATED WITH FACULTATIVE MICROFLORA, AS EXEMPLIFIED BY A POLYCOMPONENT IMMUNOVAC VP4 VACCINE
title_fullStr	AN IMMUNOTHERAPEUTIC CONCEPT OF MICROBIAL ANTIGEN APPLICATION IN ATOPY AND DISORDERS ASSOCIATED WITH FACULTATIVE MICROFLORA, AS EXEMPLIFIED BY A POLYCOMPONENT IMMUNOVAC VP4 VACCINE
title_full_unstemmed	AN IMMUNOTHERAPEUTIC CONCEPT OF MICROBIAL ANTIGEN APPLICATION IN ATOPY AND DISORDERS ASSOCIATED WITH FACULTATIVE MICROFLORA, AS EXEMPLIFIED BY A POLYCOMPONENT IMMUNOVAC VP4 VACCINE
title_sort	immunotherapeutic concept of microbial antigen application in atopy and disorders associated with facultative microflora, as exemplified by a polycomponent immunovac vp4 vaccine
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/461e0f19242a49779167609565a360ca
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AN IMMUNOTHERAPEUTIC CONCEPT OF MICROBIAL ANTIGEN APPLICATION IN ATOPY AND DISORDERS ASSOCIATED WITH FACULTATIVE MICROFLORA, AS EXEMPLIFIED BY A POLYCOMPONENT IMMUNOVAC VP4 VACCINE

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