Enhancing titres of therapeutic viral vectors using the transgene repression in vector production (TRiP) system

The maximum titre of therapeutic viral vectors can be adversely affected by the encoded transgene. Here the authors repress transgene expression in producing cells by employing the tryptophan RNA-binding attenuation protein and show that it improves titre of RNA- and DNA-based viral vectors expressi...

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Autores principales:	H. E. Maunder, J. Wright, B. R. Kolli, C. R. Vieira, T. T. Mkandawire, S. Tatoris, V. Kennedy, S. Iqball, G. Devarajan, S. Ellis, Y. Lad, N. G. Clarkson, K. A. Mitrophanous, D. C. Farley
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/461f4560315c4da1a66c68b9087e432c
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spelling	oai:doaj.org-article:461f4560315c4da1a66c68b9087e432c2021-12-02T14:42:18ZEnhancing titres of therapeutic viral vectors using the transgene repression in vector production (TRiP) system10.1038/ncomms148342041-1723https://doaj.org/article/461f4560315c4da1a66c68b9087e432c2017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14834https://doaj.org/toc/2041-1723The maximum titre of therapeutic viral vectors can be adversely affected by the encoded transgene. Here the authors repress transgene expression in producing cells by employing the tryptophan RNA-binding attenuation protein and show that it improves titre of RNA- and DNA-based viral vectors expressing toxic transgenes.H. E. MaunderJ. WrightB. R. KolliC. R. VieiraT. T. MkandawireS. TatorisV. KennedyS. IqballG. DevarajanS. EllisY. LadN. G. ClarksonK. A. MitrophanousD. C. FarleyNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q H. E. Maunder J. Wright B. R. Kolli C. R. Vieira T. T. Mkandawire S. Tatoris V. Kennedy S. Iqball G. Devarajan S. Ellis Y. Lad N. G. Clarkson K. A. Mitrophanous D. C. Farley Enhancing titres of therapeutic viral vectors using the transgene repression in vector production (TRiP) system
description	The maximum titre of therapeutic viral vectors can be adversely affected by the encoded transgene. Here the authors repress transgene expression in producing cells by employing the tryptophan RNA-binding attenuation protein and show that it improves titre of RNA- and DNA-based viral vectors expressing toxic transgenes.
format	article
author	H. E. Maunder J. Wright B. R. Kolli C. R. Vieira T. T. Mkandawire S. Tatoris V. Kennedy S. Iqball G. Devarajan S. Ellis Y. Lad N. G. Clarkson K. A. Mitrophanous D. C. Farley
author_facet	H. E. Maunder J. Wright B. R. Kolli C. R. Vieira T. T. Mkandawire S. Tatoris V. Kennedy S. Iqball G. Devarajan S. Ellis Y. Lad N. G. Clarkson K. A. Mitrophanous D. C. Farley
author_sort	H. E. Maunder
title	Enhancing titres of therapeutic viral vectors using the transgene repression in vector production (TRiP) system
title_short	Enhancing titres of therapeutic viral vectors using the transgene repression in vector production (TRiP) system
title_full	Enhancing titres of therapeutic viral vectors using the transgene repression in vector production (TRiP) system
title_fullStr	Enhancing titres of therapeutic viral vectors using the transgene repression in vector production (TRiP) system
title_full_unstemmed	Enhancing titres of therapeutic viral vectors using the transgene repression in vector production (TRiP) system
title_sort	enhancing titres of therapeutic viral vectors using the transgene repression in vector production (trip) system
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/461f4560315c4da1a66c68b9087e432c
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Enhancing titres of therapeutic viral vectors using the transgene repression in vector production (TRiP) system

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