Vascular Tissue Specific miRNA Profiles Reveal Novel Correlations with Risk Factors in Coronary Artery Disease

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. Non-coding RNAs have already been linked to CVD development and progression. While microRNAs (miRs) have been well studied in blood samples, there is little data on tissue-specific miRs in cardiovascular relevant...

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Autores principales:	Katrīna D. Neiburga, Baiba Vilne, Sabine Bauer, Dario Bongiovanni, Tilman Ziegler, Mark Lachmann, Simon Wengert, Johann S. Hawe, Ulrich Güldener, Annie M. Westerlund, Ling Li, Shichao Pang, Chuhua Yang, Kathrin Saar, Norbert Huebner, Lars Maegdefessel, DigiMed Bayern Consortium, Rüdiger Lange, Markus Krane, Heribert Schunkert, Moritz von Scheidt
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	arteria mammaria interna biomarker biosensor coronary artery disease coronary artery bypass grafting cardiovascular disease Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/461fbf4139ca4d3e9c7585eb265c814c
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spelling	oai:doaj.org-article:461fbf4139ca4d3e9c7585eb265c814c2021-11-25T16:53:48ZVascular Tissue Specific miRNA Profiles Reveal Novel Correlations with Risk Factors in Coronary Artery Disease10.3390/biom111116832218-273Xhttps://doaj.org/article/461fbf4139ca4d3e9c7585eb265c814c2021-11-01T00:00:00Zhttps://www.mdpi.com/2218-273X/11/11/1683https://doaj.org/toc/2218-273XCardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. Non-coding RNAs have already been linked to CVD development and progression. While microRNAs (miRs) have been well studied in blood samples, there is little data on tissue-specific miRs in cardiovascular relevant tissues and their relation to cardiovascular risk factors. Tissue-specific miRs derived from <i>Arteria mammaria interna</i> (IMA) from 192 coronary artery disease (CAD) patients undergoing coronary artery bypass grafting (CABG) were analyzed. The aims of the study were 1) to establish a reference atlas which can be utilized for identification of novel diagnostic biomarkers and potential therapeutic targets, and 2) to relate these miRs to cardiovascular risk factors. Overall, 393 individual miRs showed sufficient expression levels and passed quality control for further analysis. We identified 17 miRs–miR-10b-3p, miR-10-5p, miR-17-3p, miR-21-5p, miR-151a-5p, miR-181a-5p, miR-185-5p, miR-194-5p, miR-199a-3p, miR-199b-3p, miR-212-3p, miR-363-3p, miR-548d-5p, miR-744-5p, miR-3117-3p, miR-5683 and miR-5701–significantly correlated with cardiovascular risk factors (correlation coefficient >0.2 in both directions, <i>p</i>-value (<i>p</i> < 0.006, false discovery rate (FDR) <0.05). Of particular interest, miR-5701 was positively correlated with hypertension, hypercholesterolemia, and diabetes. In addition, we found that miR-629-5p and miR-98-5p were significantly correlated with acute myocardial infarction. We provide a first atlas of miR profiles in IMA samples from CAD patients. In perspective, these miRs might play an important role in improved risk assessment, mechanistic disease understanding and local therapy of CAD.Katrīna D. NeiburgaBaiba VilneSabine BauerDario BongiovanniTilman ZieglerMark LachmannSimon WengertJohann S. HaweUlrich GüldenerAnnie M. WesterlundLing LiShichao PangChuhua YangKathrin SaarNorbert HuebnerLars MaegdefesselDigiMed Bayern ConsortiumRüdiger LangeMarkus KraneHeribert SchunkertMoritz von ScheidtMDPI AGarticlearteria mammaria internabiomarkerbiosensorcoronary artery diseasecoronary artery bypass graftingcardiovascular diseaseMicrobiologyQR1-502ENBiomolecules, Vol 11, Iss 1683, p 1683 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	arteria mammaria interna biomarker biosensor coronary artery disease coronary artery bypass grafting cardiovascular disease Microbiology QR1-502
spellingShingle	arteria mammaria interna biomarker biosensor coronary artery disease coronary artery bypass grafting cardiovascular disease Microbiology QR1-502 Katrīna D. Neiburga Baiba Vilne Sabine Bauer Dario Bongiovanni Tilman Ziegler Mark Lachmann Simon Wengert Johann S. Hawe Ulrich Güldener Annie M. Westerlund Ling Li Shichao Pang Chuhua Yang Kathrin Saar Norbert Huebner Lars Maegdefessel DigiMed Bayern Consortium Rüdiger Lange Markus Krane Heribert Schunkert Moritz von Scheidt Vascular Tissue Specific miRNA Profiles Reveal Novel Correlations with Risk Factors in Coronary Artery Disease
description	Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. Non-coding RNAs have already been linked to CVD development and progression. While microRNAs (miRs) have been well studied in blood samples, there is little data on tissue-specific miRs in cardiovascular relevant tissues and their relation to cardiovascular risk factors. Tissue-specific miRs derived from <i>Arteria mammaria interna</i> (IMA) from 192 coronary artery disease (CAD) patients undergoing coronary artery bypass grafting (CABG) were analyzed. The aims of the study were 1) to establish a reference atlas which can be utilized for identification of novel diagnostic biomarkers and potential therapeutic targets, and 2) to relate these miRs to cardiovascular risk factors. Overall, 393 individual miRs showed sufficient expression levels and passed quality control for further analysis. We identified 17 miRs–miR-10b-3p, miR-10-5p, miR-17-3p, miR-21-5p, miR-151a-5p, miR-181a-5p, miR-185-5p, miR-194-5p, miR-199a-3p, miR-199b-3p, miR-212-3p, miR-363-3p, miR-548d-5p, miR-744-5p, miR-3117-3p, miR-5683 and miR-5701–significantly correlated with cardiovascular risk factors (correlation coefficient >0.2 in both directions, <i>p</i>-value (<i>p</i> < 0.006, false discovery rate (FDR) <0.05). Of particular interest, miR-5701 was positively correlated with hypertension, hypercholesterolemia, and diabetes. In addition, we found that miR-629-5p and miR-98-5p were significantly correlated with acute myocardial infarction. We provide a first atlas of miR profiles in IMA samples from CAD patients. In perspective, these miRs might play an important role in improved risk assessment, mechanistic disease understanding and local therapy of CAD.
format	article
author	Katrīna D. Neiburga Baiba Vilne Sabine Bauer Dario Bongiovanni Tilman Ziegler Mark Lachmann Simon Wengert Johann S. Hawe Ulrich Güldener Annie M. Westerlund Ling Li Shichao Pang Chuhua Yang Kathrin Saar Norbert Huebner Lars Maegdefessel DigiMed Bayern Consortium Rüdiger Lange Markus Krane Heribert Schunkert Moritz von Scheidt
author_facet	Katrīna D. Neiburga Baiba Vilne Sabine Bauer Dario Bongiovanni Tilman Ziegler Mark Lachmann Simon Wengert Johann S. Hawe Ulrich Güldener Annie M. Westerlund Ling Li Shichao Pang Chuhua Yang Kathrin Saar Norbert Huebner Lars Maegdefessel DigiMed Bayern Consortium Rüdiger Lange Markus Krane Heribert Schunkert Moritz von Scheidt
author_sort	Katrīna D. Neiburga
title	Vascular Tissue Specific miRNA Profiles Reveal Novel Correlations with Risk Factors in Coronary Artery Disease
title_short	Vascular Tissue Specific miRNA Profiles Reveal Novel Correlations with Risk Factors in Coronary Artery Disease
title_full	Vascular Tissue Specific miRNA Profiles Reveal Novel Correlations with Risk Factors in Coronary Artery Disease
title_fullStr	Vascular Tissue Specific miRNA Profiles Reveal Novel Correlations with Risk Factors in Coronary Artery Disease
title_full_unstemmed	Vascular Tissue Specific miRNA Profiles Reveal Novel Correlations with Risk Factors in Coronary Artery Disease
title_sort	vascular tissue specific mirna profiles reveal novel correlations with risk factors in coronary artery disease
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/461fbf4139ca4d3e9c7585eb265c814c
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Vascular Tissue Specific miRNA Profiles Reveal Novel Correlations with Risk Factors in Coronary Artery Disease

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