Inflammation triggers immediate rather than progressive changes in monocyte differentiation in the small intestine

Bone marrow-derived monocytes are recruited to the gut to replenish the local macrophage pool. Here the authors show that, while such replenishment constitutively occur under homeostasis, gut inflammation induces an immediate, Trem1-related transcription change to recruited monocyte to enable a cont...

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Autores principales:	Girmay Desalegn, Oliver Pabst
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/461fd3382089405f9f365d5e2de08786
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spelling	oai:doaj.org-article:461fd3382089405f9f365d5e2de087862021-12-02T15:35:09ZInflammation triggers immediate rather than progressive changes in monocyte differentiation in the small intestine10.1038/s41467-019-11148-22041-1723https://doaj.org/article/461fd3382089405f9f365d5e2de087862019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11148-2https://doaj.org/toc/2041-1723Bone marrow-derived monocytes are recruited to the gut to replenish the local macrophage pool. Here the authors show that, while such replenishment constitutively occur under homeostasis, gut inflammation induces an immediate, Trem1-related transcription change to recruited monocyte to enable a context-dependent modulation of macrophage functions.Girmay DesalegnOliver PabstNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Girmay Desalegn Oliver Pabst Inflammation triggers immediate rather than progressive changes in monocyte differentiation in the small intestine
description	Bone marrow-derived monocytes are recruited to the gut to replenish the local macrophage pool. Here the authors show that, while such replenishment constitutively occur under homeostasis, gut inflammation induces an immediate, Trem1-related transcription change to recruited monocyte to enable a context-dependent modulation of macrophage functions.
format	article
author	Girmay Desalegn Oliver Pabst
author_facet	Girmay Desalegn Oliver Pabst
author_sort	Girmay Desalegn
title	Inflammation triggers immediate rather than progressive changes in monocyte differentiation in the small intestine
title_short	Inflammation triggers immediate rather than progressive changes in monocyte differentiation in the small intestine
title_full	Inflammation triggers immediate rather than progressive changes in monocyte differentiation in the small intestine
title_fullStr	Inflammation triggers immediate rather than progressive changes in monocyte differentiation in the small intestine
title_full_unstemmed	Inflammation triggers immediate rather than progressive changes in monocyte differentiation in the small intestine
title_sort	inflammation triggers immediate rather than progressive changes in monocyte differentiation in the small intestine
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/461fd3382089405f9f365d5e2de08786
work_keys_str_mv	AT girmaydesalegn inflammationtriggersimmediateratherthanprogressivechangesinmonocytedifferentiationinthesmallintestine AT oliverpabst inflammationtriggersimmediateratherthanprogressivechangesinmonocytedifferentiationinthesmallintestine
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Inflammation triggers immediate rather than progressive changes in monocyte differentiation in the small intestine

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