Sex and APOE ε4 genotype modify the Alzheimer’s disease serum metabolome
Sex and the APOE ε4 genotype are important risk factors for late-onset Alzheimer’s disease. In the current study, the authors investigate how sex and APOE ε4 genotype modify the association between Alzheimer’s disease biomarkers and metabolites in serum.
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Nature Portfolio
2020
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oai:doaj.org-article:4622f4afa16f4c509372906b7b40a13c2021-12-02T15:37:12ZSex and APOE ε4 genotype modify the Alzheimer’s disease serum metabolome10.1038/s41467-020-14959-w2041-1723https://doaj.org/article/4622f4afa16f4c509372906b7b40a13c2020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14959-whttps://doaj.org/toc/2041-1723Sex and the APOE ε4 genotype are important risk factors for late-onset Alzheimer’s disease. In the current study, the authors investigate how sex and APOE ε4 genotype modify the association between Alzheimer’s disease biomarkers and metabolites in serum.Matthias ArnoldKwangsik NhoAlexandra Kueider-PaisleyTyler MassaroKevin HuynhBarbara BraunerSiamak MahmoudianDehkordiGregory LouieM. Arthur MoseleyJ. Will ThompsonLisa St John-WilliamsJessica D. TenenbaumColette BlachRui ChangRoberta D. BrintonRebecca BaillieXianlin HanJohn Q. TrojanowskiLeslie M. ShawRalph MartinsMichael W. WeinerEugenia TrushinaJon B. ToledoPeter J. MeikleDavid A. BennettJan KrumsiekP. Murali DoraiswamyAndrew J. SaykinRima Kaddurah-DaoukGabi KastenmüllerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Matthias Arnold Kwangsik Nho Alexandra Kueider-Paisley Tyler Massaro Kevin Huynh Barbara Brauner Siamak MahmoudianDehkordi Gregory Louie M. Arthur Moseley J. Will Thompson Lisa St John-Williams Jessica D. Tenenbaum Colette Blach Rui Chang Roberta D. Brinton Rebecca Baillie Xianlin Han John Q. Trojanowski Leslie M. Shaw Ralph Martins Michael W. Weiner Eugenia Trushina Jon B. Toledo Peter J. Meikle David A. Bennett Jan Krumsiek P. Murali Doraiswamy Andrew J. Saykin Rima Kaddurah-Daouk Gabi Kastenmüller Sex and APOE ε4 genotype modify the Alzheimer’s disease serum metabolome |
| description |
Sex and the APOE ε4 genotype are important risk factors for late-onset Alzheimer’s disease. In the current study, the authors investigate how sex and APOE ε4 genotype modify the association between Alzheimer’s disease biomarkers and metabolites in serum. |
| format |
article |
| author |
Matthias Arnold Kwangsik Nho Alexandra Kueider-Paisley Tyler Massaro Kevin Huynh Barbara Brauner Siamak MahmoudianDehkordi Gregory Louie M. Arthur Moseley J. Will Thompson Lisa St John-Williams Jessica D. Tenenbaum Colette Blach Rui Chang Roberta D. Brinton Rebecca Baillie Xianlin Han John Q. Trojanowski Leslie M. Shaw Ralph Martins Michael W. Weiner Eugenia Trushina Jon B. Toledo Peter J. Meikle David A. Bennett Jan Krumsiek P. Murali Doraiswamy Andrew J. Saykin Rima Kaddurah-Daouk Gabi Kastenmüller |
| author_facet |
Matthias Arnold Kwangsik Nho Alexandra Kueider-Paisley Tyler Massaro Kevin Huynh Barbara Brauner Siamak MahmoudianDehkordi Gregory Louie M. Arthur Moseley J. Will Thompson Lisa St John-Williams Jessica D. Tenenbaum Colette Blach Rui Chang Roberta D. Brinton Rebecca Baillie Xianlin Han John Q. Trojanowski Leslie M. Shaw Ralph Martins Michael W. Weiner Eugenia Trushina Jon B. Toledo Peter J. Meikle David A. Bennett Jan Krumsiek P. Murali Doraiswamy Andrew J. Saykin Rima Kaddurah-Daouk Gabi Kastenmüller |
| author_sort |
Matthias Arnold |
| title |
Sex and APOE ε4 genotype modify the Alzheimer’s disease serum metabolome |
| title_short |
Sex and APOE ε4 genotype modify the Alzheimer’s disease serum metabolome |
| title_full |
Sex and APOE ε4 genotype modify the Alzheimer’s disease serum metabolome |
| title_fullStr |
Sex and APOE ε4 genotype modify the Alzheimer’s disease serum metabolome |
| title_full_unstemmed |
Sex and APOE ε4 genotype modify the Alzheimer’s disease serum metabolome |
| title_sort |
sex and apoe ε4 genotype modify the alzheimer’s disease serum metabolome |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/4622f4afa16f4c509372906b7b40a13c |
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