Transcriptional changes and the role of ONECUT1 in hPSC pancreatic differentiation

Heller et al analyze transcriptomic and epigenetic datasets from human PSCs differentiating into pancreatic progenitors to elucidate the regulatory mechanisms behind pancreatic development. The authors report that the transcription factor ONECUT1 is expressed specifically in pancreatic development a...

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Autores principales:	Sandra Heller, Zhijian Li, Qiong Lin, Ryan Geusz, Markus Breunig, Meike Hohwieler, Xi Zhang, Gopika G. Nair, Thomas Seufferlein, Matthias Hebrok, Maike Sander, Cécile Julier, Alexander Kleger, Ivan G. Costa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/4622ff7d00c840df9df59d2628589a8c
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spelling	oai:doaj.org-article:4622ff7d00c840df9df59d2628589a8c2021-11-21T12:08:25ZTranscriptional changes and the role of ONECUT1 in hPSC pancreatic differentiation10.1038/s42003-021-02818-32399-3642https://doaj.org/article/4622ff7d00c840df9df59d2628589a8c2021-11-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02818-3https://doaj.org/toc/2399-3642Heller et al analyze transcriptomic and epigenetic datasets from human PSCs differentiating into pancreatic progenitors to elucidate the regulatory mechanisms behind pancreatic development. The authors report that the transcription factor ONECUT1 is expressed specifically in pancreatic development and associates with other key TFs (such as FOXA2, GATA6, PDX1) during endocrine specification.Sandra HellerZhijian LiQiong LinRyan GeuszMarkus BreunigMeike HohwielerXi ZhangGopika G. NairThomas SeufferleinMatthias HebrokMaike SanderCécile JulierAlexander KlegerIvan G. CostaNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Sandra Heller Zhijian Li Qiong Lin Ryan Geusz Markus Breunig Meike Hohwieler Xi Zhang Gopika G. Nair Thomas Seufferlein Matthias Hebrok Maike Sander Cécile Julier Alexander Kleger Ivan G. Costa Transcriptional changes and the role of ONECUT1 in hPSC pancreatic differentiation
description	Heller et al analyze transcriptomic and epigenetic datasets from human PSCs differentiating into pancreatic progenitors to elucidate the regulatory mechanisms behind pancreatic development. The authors report that the transcription factor ONECUT1 is expressed specifically in pancreatic development and associates with other key TFs (such as FOXA2, GATA6, PDX1) during endocrine specification.
format	article
author	Sandra Heller Zhijian Li Qiong Lin Ryan Geusz Markus Breunig Meike Hohwieler Xi Zhang Gopika G. Nair Thomas Seufferlein Matthias Hebrok Maike Sander Cécile Julier Alexander Kleger Ivan G. Costa
author_facet	Sandra Heller Zhijian Li Qiong Lin Ryan Geusz Markus Breunig Meike Hohwieler Xi Zhang Gopika G. Nair Thomas Seufferlein Matthias Hebrok Maike Sander Cécile Julier Alexander Kleger Ivan G. Costa
author_sort	Sandra Heller
title	Transcriptional changes and the role of ONECUT1 in hPSC pancreatic differentiation
title_short	Transcriptional changes and the role of ONECUT1 in hPSC pancreatic differentiation
title_full	Transcriptional changes and the role of ONECUT1 in hPSC pancreatic differentiation
title_fullStr	Transcriptional changes and the role of ONECUT1 in hPSC pancreatic differentiation
title_full_unstemmed	Transcriptional changes and the role of ONECUT1 in hPSC pancreatic differentiation
title_sort	transcriptional changes and the role of onecut1 in hpsc pancreatic differentiation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4622ff7d00c840df9df59d2628589a8c
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Transcriptional changes and the role of ONECUT1 in hPSC pancreatic differentiation

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