Epilepsy and intellectual disability linked protein Shrm4 interaction with GABABRs shapes inhibitory neurotransmission
Mutations in the gene encoding Shrm4 are associated with epilepsy and intellectual disability. The authors show that Shrm4 interacts with GABABreceptors and regulates tonic inhibition in the hippocampus, and knockdown of Shrm4 in rats leads to anxiety-like behaviour and seizures.
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Nature Portfolio
2017
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oai:doaj.org-article:4624279b47d64159ad6a26ab96fc80e02021-12-02T15:37:04ZEpilepsy and intellectual disability linked protein Shrm4 interaction with GABABRs shapes inhibitory neurotransmission10.1038/ncomms145362041-1723https://doaj.org/article/4624279b47d64159ad6a26ab96fc80e02017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14536https://doaj.org/toc/2041-1723Mutations in the gene encoding Shrm4 are associated with epilepsy and intellectual disability. The authors show that Shrm4 interacts with GABABreceptors and regulates tonic inhibition in the hippocampus, and knockdown of Shrm4 in rats leads to anxiety-like behaviour and seizures.Jonathan ZapataEdoardo MorettoSaad HannanLuca MurruAnna LongattiDavide MazzaLorena BenedettiMatteo FossatiChristopher HeiseLuisa PonzoniPamela ValnegriDaniela BraidaMariaelvina SalaMaura FrancoliniJeffrey HildebrandVera KalscheuerFrancesca FanelliCarlo SalaBernhard BettlerSilvia BassaniTrevor G. SmartMaria PassafaroNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017) |
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DOAJ |
| language |
EN |
| topic |
Science Q |
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Science Q Jonathan Zapata Edoardo Moretto Saad Hannan Luca Murru Anna Longatti Davide Mazza Lorena Benedetti Matteo Fossati Christopher Heise Luisa Ponzoni Pamela Valnegri Daniela Braida Mariaelvina Sala Maura Francolini Jeffrey Hildebrand Vera Kalscheuer Francesca Fanelli Carlo Sala Bernhard Bettler Silvia Bassani Trevor G. Smart Maria Passafaro Epilepsy and intellectual disability linked protein Shrm4 interaction with GABABRs shapes inhibitory neurotransmission |
| description |
Mutations in the gene encoding Shrm4 are associated with epilepsy and intellectual disability. The authors show that Shrm4 interacts with GABABreceptors and regulates tonic inhibition in the hippocampus, and knockdown of Shrm4 in rats leads to anxiety-like behaviour and seizures. |
| format |
article |
| author |
Jonathan Zapata Edoardo Moretto Saad Hannan Luca Murru Anna Longatti Davide Mazza Lorena Benedetti Matteo Fossati Christopher Heise Luisa Ponzoni Pamela Valnegri Daniela Braida Mariaelvina Sala Maura Francolini Jeffrey Hildebrand Vera Kalscheuer Francesca Fanelli Carlo Sala Bernhard Bettler Silvia Bassani Trevor G. Smart Maria Passafaro |
| author_facet |
Jonathan Zapata Edoardo Moretto Saad Hannan Luca Murru Anna Longatti Davide Mazza Lorena Benedetti Matteo Fossati Christopher Heise Luisa Ponzoni Pamela Valnegri Daniela Braida Mariaelvina Sala Maura Francolini Jeffrey Hildebrand Vera Kalscheuer Francesca Fanelli Carlo Sala Bernhard Bettler Silvia Bassani Trevor G. Smart Maria Passafaro |
| author_sort |
Jonathan Zapata |
| title |
Epilepsy and intellectual disability linked protein Shrm4 interaction with GABABRs shapes inhibitory neurotransmission |
| title_short |
Epilepsy and intellectual disability linked protein Shrm4 interaction with GABABRs shapes inhibitory neurotransmission |
| title_full |
Epilepsy and intellectual disability linked protein Shrm4 interaction with GABABRs shapes inhibitory neurotransmission |
| title_fullStr |
Epilepsy and intellectual disability linked protein Shrm4 interaction with GABABRs shapes inhibitory neurotransmission |
| title_full_unstemmed |
Epilepsy and intellectual disability linked protein Shrm4 interaction with GABABRs shapes inhibitory neurotransmission |
| title_sort |
epilepsy and intellectual disability linked protein shrm4 interaction with gababrs shapes inhibitory neurotransmission |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/4624279b47d64159ad6a26ab96fc80e0 |
| work_keys_str_mv |
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