Methylation analysis of plasma DNA informs etiologies of Epstein-Barr virus-associated diseases

Epstein-Barr virus (EBV) is associated with different malignant diseases and circulating EBV DNA is a biomarker for nasopharyngeal carcinoma (NPC). Here, the authors report that plasma EBV DNA methylation profiles show disease-associated patterns and can help to distinguish NPC and non-NPC subjects.

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Autores principales: W. K. Jacky Lam, Peiyong Jiang, K. C. Allen Chan, Wenlei Peng, Huimin Shang, Macy M. S. Heung, Suk Hang Cheng, Haiqiang Zhang, O. Y. Olivia Tse, Radha Raghupathy, Brigette B. Y. Ma, Edwin P. Hui, Anthony T. C. Chan, John K. S. Woo, Rossa W. K. Chiu, Y. M. Dennis Lo
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Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/4628833b96ef42e198ec3810d5f38f5d
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spelling oai:doaj.org-article:4628833b96ef42e198ec3810d5f38f5d2021-12-02T15:35:56ZMethylation analysis of plasma DNA informs etiologies of Epstein-Barr virus-associated diseases10.1038/s41467-019-11226-52041-1723https://doaj.org/article/4628833b96ef42e198ec3810d5f38f5d2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11226-5https://doaj.org/toc/2041-1723Epstein-Barr virus (EBV) is associated with different malignant diseases and circulating EBV DNA is a biomarker for nasopharyngeal carcinoma (NPC). Here, the authors report that plasma EBV DNA methylation profiles show disease-associated patterns and can help to distinguish NPC and non-NPC subjects.W. K. Jacky LamPeiyong JiangK. C. Allen ChanWenlei PengHuimin ShangMacy M. S. HeungSuk Hang ChengHaiqiang ZhangO. Y. Olivia TseRadha RaghupathyBrigette B. Y. MaEdwin P. HuiAnthony T. C. ChanJohn K. S. WooRossa W. K. ChiuY. M. Dennis LoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
W. K. Jacky Lam
Peiyong Jiang
K. C. Allen Chan
Wenlei Peng
Huimin Shang
Macy M. S. Heung
Suk Hang Cheng
Haiqiang Zhang
O. Y. Olivia Tse
Radha Raghupathy
Brigette B. Y. Ma
Edwin P. Hui
Anthony T. C. Chan
John K. S. Woo
Rossa W. K. Chiu
Y. M. Dennis Lo
Methylation analysis of plasma DNA informs etiologies of Epstein-Barr virus-associated diseases
description Epstein-Barr virus (EBV) is associated with different malignant diseases and circulating EBV DNA is a biomarker for nasopharyngeal carcinoma (NPC). Here, the authors report that plasma EBV DNA methylation profiles show disease-associated patterns and can help to distinguish NPC and non-NPC subjects.
format article
author W. K. Jacky Lam
Peiyong Jiang
K. C. Allen Chan
Wenlei Peng
Huimin Shang
Macy M. S. Heung
Suk Hang Cheng
Haiqiang Zhang
O. Y. Olivia Tse
Radha Raghupathy
Brigette B. Y. Ma
Edwin P. Hui
Anthony T. C. Chan
John K. S. Woo
Rossa W. K. Chiu
Y. M. Dennis Lo
author_facet W. K. Jacky Lam
Peiyong Jiang
K. C. Allen Chan
Wenlei Peng
Huimin Shang
Macy M. S. Heung
Suk Hang Cheng
Haiqiang Zhang
O. Y. Olivia Tse
Radha Raghupathy
Brigette B. Y. Ma
Edwin P. Hui
Anthony T. C. Chan
John K. S. Woo
Rossa W. K. Chiu
Y. M. Dennis Lo
author_sort W. K. Jacky Lam
title Methylation analysis of plasma DNA informs etiologies of Epstein-Barr virus-associated diseases
title_short Methylation analysis of plasma DNA informs etiologies of Epstein-Barr virus-associated diseases
title_full Methylation analysis of plasma DNA informs etiologies of Epstein-Barr virus-associated diseases
title_fullStr Methylation analysis of plasma DNA informs etiologies of Epstein-Barr virus-associated diseases
title_full_unstemmed Methylation analysis of plasma DNA informs etiologies of Epstein-Barr virus-associated diseases
title_sort methylation analysis of plasma dna informs etiologies of epstein-barr virus-associated diseases
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/4628833b96ef42e198ec3810d5f38f5d
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