TMS-EEG Biomarkers of Amnestic Mild Cognitive Impairment Due to Alzheimer’s Disease: A Proof-of-Concept Six Years Prospective Study

Background: Early and affordable identification of subjects with amnestic mild cognitive impairment (aMCI) who will convert to Alzheimer’s disease (AD) is a major scientific challenge.Objective: To investigate the neurophysiological hallmarks of sensorimotor cortex function in aMCI under the hypothe...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Florinda Ferreri, Andrea Guerra, Luca Vollero, David Ponzo, Sara Määtta, Mervi Könönen, Fabrizio Vecchio, Patrizio Pasqualetti, Francesca Miraglia, Ilaria Simonelli, Maurizio Corbetta, Paolo Maria Rossini
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	mild cognitive impairment (MCI) Alzheimer’s disease (AD) electroencephalography (EEG) navigated transcranial magnetic stimulation (nTMS) TMS-EEG coregistration Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/4628d177c3804ac081fd71f7aae87361
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4628d177c3804ac081fd71f7aae87361
record_format	dspace
spelling	oai:doaj.org-article:4628d177c3804ac081fd71f7aae873612021-11-22T06:09:11ZTMS-EEG Biomarkers of Amnestic Mild Cognitive Impairment Due to Alzheimer’s Disease: A Proof-of-Concept Six Years Prospective Study1663-436510.3389/fnagi.2021.737281https://doaj.org/article/4628d177c3804ac081fd71f7aae873612021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnagi.2021.737281/fullhttps://doaj.org/toc/1663-4365Background: Early and affordable identification of subjects with amnestic mild cognitive impairment (aMCI) who will convert to Alzheimer’s disease (AD) is a major scientific challenge.Objective: To investigate the neurophysiological hallmarks of sensorimotor cortex function in aMCI under the hypothesis that some may represent the plastic rearrangements induced by neurodegeneration, hence predictors of future conversion to AD. We sought to determine (1) whether the sensorimotor network shows peculiar alterations in patients with aMCI and (2) if sensorimotor network alterations predict long-term disease progression at the individual level.Methods: We studied several transcranial magnetic stimulation (TMS)-electroencephalogram (EEG) parameters of the sensorimotor cortex in a group of patients with aMCI and followed them for 6 years. We then identified aMCI who clinically converted to AD [prodromal to AD-MCI (pAD-MCI)] and those who remained cognitively stable [non-prodromal to AD-MCI (npAD-MCI)].Results: Patients with aMCI showed reduced motor cortex (M1) excitability and disrupted EEG synchronization [decreased intertrial coherence (ITC)] in alpha, beta and gamma frequency bands compared to the control subjects. The degree of alteration in M1 excitability and alpha ITC was comparable between pAD-MCI and npAD-MCI. Importantly, beta and gamma ITC impairment in the stimulated M1 was greater in pAD-MCI than npAD-MCI. Furthermore, an additional parameter related to the waveform shape of scalp signals, reflecting time-specific alterations in global TMS-induced activity [stability of the dipolar activity (sDA)], discriminated npAD-MCI from MCI who will convert to AD.Discussion: The above mentioned specific cortical changes, reflecting deficit of synchronization within the cortico-basal ganglia-thalamo-cortical loop in aMCI, may reflect the pathological processes underlying AD. These changes could be tested in larger cohorts as neurophysiological biomarkers of AD.Florinda FerreriFlorinda FerreriAndrea GuerraLuca VolleroDavid PonzoDavid PonzoSara MäättaMervi KönönenFabrizio VecchioFabrizio VecchioPatrizio PasqualettiFrancesca MiragliaIlaria SimonelliMaurizio CorbettaMaurizio CorbettaMaurizio CorbettaPaolo Maria RossiniFrontiers Media S.A.articlemild cognitive impairment (MCI)Alzheimer’s disease (AD)electroencephalography (EEG)navigated transcranial magnetic stimulation (nTMS)TMS-EEG coregistrationNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Aging Neuroscience, Vol 13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mild cognitive impairment (MCI) Alzheimer’s disease (AD) electroencephalography (EEG) navigated transcranial magnetic stimulation (nTMS) TMS-EEG coregistration Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	mild cognitive impairment (MCI) Alzheimer’s disease (AD) electroencephalography (EEG) navigated transcranial magnetic stimulation (nTMS) TMS-EEG coregistration Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Florinda Ferreri Florinda Ferreri Andrea Guerra Luca Vollero David Ponzo David Ponzo Sara Määtta Mervi Könönen Fabrizio Vecchio Fabrizio Vecchio Patrizio Pasqualetti Francesca Miraglia Ilaria Simonelli Maurizio Corbetta Maurizio Corbetta Maurizio Corbetta Paolo Maria Rossini TMS-EEG Biomarkers of Amnestic Mild Cognitive Impairment Due to Alzheimer’s Disease: A Proof-of-Concept Six Years Prospective Study
description	Background: Early and affordable identification of subjects with amnestic mild cognitive impairment (aMCI) who will convert to Alzheimer’s disease (AD) is a major scientific challenge.Objective: To investigate the neurophysiological hallmarks of sensorimotor cortex function in aMCI under the hypothesis that some may represent the plastic rearrangements induced by neurodegeneration, hence predictors of future conversion to AD. We sought to determine (1) whether the sensorimotor network shows peculiar alterations in patients with aMCI and (2) if sensorimotor network alterations predict long-term disease progression at the individual level.Methods: We studied several transcranial magnetic stimulation (TMS)-electroencephalogram (EEG) parameters of the sensorimotor cortex in a group of patients with aMCI and followed them for 6 years. We then identified aMCI who clinically converted to AD [prodromal to AD-MCI (pAD-MCI)] and those who remained cognitively stable [non-prodromal to AD-MCI (npAD-MCI)].Results: Patients with aMCI showed reduced motor cortex (M1) excitability and disrupted EEG synchronization [decreased intertrial coherence (ITC)] in alpha, beta and gamma frequency bands compared to the control subjects. The degree of alteration in M1 excitability and alpha ITC was comparable between pAD-MCI and npAD-MCI. Importantly, beta and gamma ITC impairment in the stimulated M1 was greater in pAD-MCI than npAD-MCI. Furthermore, an additional parameter related to the waveform shape of scalp signals, reflecting time-specific alterations in global TMS-induced activity [stability of the dipolar activity (sDA)], discriminated npAD-MCI from MCI who will convert to AD.Discussion: The above mentioned specific cortical changes, reflecting deficit of synchronization within the cortico-basal ganglia-thalamo-cortical loop in aMCI, may reflect the pathological processes underlying AD. These changes could be tested in larger cohorts as neurophysiological biomarkers of AD.
format	article
author	Florinda Ferreri Florinda Ferreri Andrea Guerra Luca Vollero David Ponzo David Ponzo Sara Määtta Mervi Könönen Fabrizio Vecchio Fabrizio Vecchio Patrizio Pasqualetti Francesca Miraglia Ilaria Simonelli Maurizio Corbetta Maurizio Corbetta Maurizio Corbetta Paolo Maria Rossini
author_facet	Florinda Ferreri Florinda Ferreri Andrea Guerra Luca Vollero David Ponzo David Ponzo Sara Määtta Mervi Könönen Fabrizio Vecchio Fabrizio Vecchio Patrizio Pasqualetti Francesca Miraglia Ilaria Simonelli Maurizio Corbetta Maurizio Corbetta Maurizio Corbetta Paolo Maria Rossini
author_sort	Florinda Ferreri
title	TMS-EEG Biomarkers of Amnestic Mild Cognitive Impairment Due to Alzheimer’s Disease: A Proof-of-Concept Six Years Prospective Study
title_short	TMS-EEG Biomarkers of Amnestic Mild Cognitive Impairment Due to Alzheimer’s Disease: A Proof-of-Concept Six Years Prospective Study
title_full	TMS-EEG Biomarkers of Amnestic Mild Cognitive Impairment Due to Alzheimer’s Disease: A Proof-of-Concept Six Years Prospective Study
title_fullStr	TMS-EEG Biomarkers of Amnestic Mild Cognitive Impairment Due to Alzheimer’s Disease: A Proof-of-Concept Six Years Prospective Study
title_full_unstemmed	TMS-EEG Biomarkers of Amnestic Mild Cognitive Impairment Due to Alzheimer’s Disease: A Proof-of-Concept Six Years Prospective Study
title_sort	tms-eeg biomarkers of amnestic mild cognitive impairment due to alzheimer’s disease: a proof-of-concept six years prospective study
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/4628d177c3804ac081fd71f7aae87361
work_keys_str_mv	AT florindaferreri tmseegbiomarkersofamnesticmildcognitiveimpairmentduetoalzheimersdiseaseaproofofconceptsixyearsprospectivestudy AT florindaferreri tmseegbiomarkersofamnesticmildcognitiveimpairmentduetoalzheimersdiseaseaproofofconceptsixyearsprospectivestudy AT andreaguerra tmseegbiomarkersofamnesticmildcognitiveimpairmentduetoalzheimersdiseaseaproofofconceptsixyearsprospectivestudy AT lucavollero tmseegbiomarkersofamnesticmildcognitiveimpairmentduetoalzheimersdiseaseaproofofconceptsixyearsprospectivestudy AT davidponzo tmseegbiomarkersofamnesticmildcognitiveimpairmentduetoalzheimersdiseaseaproofofconceptsixyearsprospectivestudy AT davidponzo tmseegbiomarkersofamnesticmildcognitiveimpairmentduetoalzheimersdiseaseaproofofconceptsixyearsprospectivestudy AT saramaatta tmseegbiomarkersofamnesticmildcognitiveimpairmentduetoalzheimersdiseaseaproofofconceptsixyearsprospectivestudy AT mervikononen tmseegbiomarkersofamnesticmildcognitiveimpairmentduetoalzheimersdiseaseaproofofconceptsixyearsprospectivestudy AT fabriziovecchio tmseegbiomarkersofamnesticmildcognitiveimpairmentduetoalzheimersdiseaseaproofofconceptsixyearsprospectivestudy AT fabriziovecchio tmseegbiomarkersofamnesticmildcognitiveimpairmentduetoalzheimersdiseaseaproofofconceptsixyearsprospectivestudy AT patriziopasqualetti tmseegbiomarkersofamnesticmildcognitiveimpairmentduetoalzheimersdiseaseaproofofconceptsixyearsprospectivestudy AT francescamiraglia tmseegbiomarkersofamnesticmildcognitiveimpairmentduetoalzheimersdiseaseaproofofconceptsixyearsprospectivestudy AT ilariasimonelli tmseegbiomarkersofamnesticmildcognitiveimpairmentduetoalzheimersdiseaseaproofofconceptsixyearsprospectivestudy AT mauriziocorbetta tmseegbiomarkersofamnesticmildcognitiveimpairmentduetoalzheimersdiseaseaproofofconceptsixyearsprospectivestudy AT mauriziocorbetta tmseegbiomarkersofamnesticmildcognitiveimpairmentduetoalzheimersdiseaseaproofofconceptsixyearsprospectivestudy AT mauriziocorbetta tmseegbiomarkersofamnesticmildcognitiveimpairmentduetoalzheimersdiseaseaproofofconceptsixyearsprospectivestudy AT paolomariarossini tmseegbiomarkersofamnesticmildcognitiveimpairmentduetoalzheimersdiseaseaproofofconceptsixyearsprospectivestudy
_version_	1718418099176210432

TMS-EEG Biomarkers of Amnestic Mild Cognitive Impairment Due to Alzheimer’s Disease: A Proof-of-Concept Six Years Prospective Study

Ejemplares similares