Smoking accelerates renal cystic disease and worsens cardiac phenotype in Pkd1-deficient mice

Abstract Smoking has been associated with renal disease progression in ADPKD but the underlying deleterious mechanisms and whether it specifically worsens the cardiac phenotype remain unknown. To investigate these matters, Pkd1-deficient cystic mice and noncystic littermates were exposed to smoking...

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Auteurs principaux: Marciana V. Sousa, Andressa G. Amaral, Jessica A. Freitas, Gilson M. Murata, Elieser H. Watanabe, Bruno E. Balbo, Marcelo D. Tavares, Renato A. Hortegal, Camila Rocon, Leandro E. Souza, Maria C. Irigoyen, Vera M. Salemi, Luiz F. Onuchic
Format: article
Langue:EN
Publié: Nature Portfolio 2021
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Accès en ligne:https://doaj.org/article/46292682db654a409c0c5c0c4473acb6
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