Quantitative ultrasound assessment of the influence of roughness and healing time on osseointegration phenomena

Abstract The evolution of bone tissue quantity and quality in contact with the surface of orthopedic and dental implants is a strong determinant of the surgical outcome but remains difficult to be assessed quantitatively. The aim of this study was to investigate the performance of a quantitative ult...

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Autores principales:	M. Fraulob, R. Vayron, S. Le Cann, B. Lecuelle, Y. Hériveaux, H. Albini Lomami, C. H. Flouzat Lachaniette, G. Haïat
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/462f3dfc82d2444aac8ed00943d3dedd
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spelling	oai:doaj.org-article:462f3dfc82d2444aac8ed00943d3dedd2021-12-02T12:40:40ZQuantitative ultrasound assessment of the influence of roughness and healing time on osseointegration phenomena10.1038/s41598-020-78806-02045-2322https://doaj.org/article/462f3dfc82d2444aac8ed00943d3dedd2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78806-0https://doaj.org/toc/2045-2322Abstract The evolution of bone tissue quantity and quality in contact with the surface of orthopedic and dental implants is a strong determinant of the surgical outcome but remains difficult to be assessed quantitatively. The aim of this study was to investigate the performance of a quantitative ultrasound (QUS) method to measure bone-implant interface (BII) properties. A dedicated animal model considering coin-shaped titanium implants with two levels of surface roughness (smooth, S a = 0.49 µm and rough, S a = 3.5 µm) allowed to work with a reproducible geometry and a planar interface. The implants were inserted in rabbit femurs and tibiae for 7 or 13 weeks. The ultrasonic response of the BII was measured ex vivo, leading to the determination of the 2-D spatial variations of bone in contact with the implant surface. Histological analysis was carried out to determine the bone-implant contact (BIC) ratio. The amplitude of the echo was significantly higher after 7 weeks of healing time compared to 13 weeks, for both smooth (p < 0.01) and rough (p < 0.05) implants. A negative correlation (R = − 0.63) was obtained between the ultrasonic response and the BIC. This QUS technique is more sensitive to changes of BII morphology compared to histological analyses.M. FraulobR. VayronS. Le CannB. LecuelleY. HériveauxH. Albini LomamiC. H. Flouzat LachanietteG. HaïatNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q M. Fraulob R. Vayron S. Le Cann B. Lecuelle Y. Hériveaux H. Albini Lomami C. H. Flouzat Lachaniette G. Haïat Quantitative ultrasound assessment of the influence of roughness and healing time on osseointegration phenomena
description	Abstract The evolution of bone tissue quantity and quality in contact with the surface of orthopedic and dental implants is a strong determinant of the surgical outcome but remains difficult to be assessed quantitatively. The aim of this study was to investigate the performance of a quantitative ultrasound (QUS) method to measure bone-implant interface (BII) properties. A dedicated animal model considering coin-shaped titanium implants with two levels of surface roughness (smooth, S a = 0.49 µm and rough, S a = 3.5 µm) allowed to work with a reproducible geometry and a planar interface. The implants were inserted in rabbit femurs and tibiae for 7 or 13 weeks. The ultrasonic response of the BII was measured ex vivo, leading to the determination of the 2-D spatial variations of bone in contact with the implant surface. Histological analysis was carried out to determine the bone-implant contact (BIC) ratio. The amplitude of the echo was significantly higher after 7 weeks of healing time compared to 13 weeks, for both smooth (p < 0.01) and rough (p < 0.05) implants. A negative correlation (R = − 0.63) was obtained between the ultrasonic response and the BIC. This QUS technique is more sensitive to changes of BII morphology compared to histological analyses.
format	article
author	M. Fraulob R. Vayron S. Le Cann B. Lecuelle Y. Hériveaux H. Albini Lomami C. H. Flouzat Lachaniette G. Haïat
author_facet	M. Fraulob R. Vayron S. Le Cann B. Lecuelle Y. Hériveaux H. Albini Lomami C. H. Flouzat Lachaniette G. Haïat
author_sort	M. Fraulob
title	Quantitative ultrasound assessment of the influence of roughness and healing time on osseointegration phenomena
title_short	Quantitative ultrasound assessment of the influence of roughness and healing time on osseointegration phenomena
title_full	Quantitative ultrasound assessment of the influence of roughness and healing time on osseointegration phenomena
title_fullStr	Quantitative ultrasound assessment of the influence of roughness and healing time on osseointegration phenomena
title_full_unstemmed	Quantitative ultrasound assessment of the influence of roughness and healing time on osseointegration phenomena
title_sort	quantitative ultrasound assessment of the influence of roughness and healing time on osseointegration phenomena
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/462f3dfc82d2444aac8ed00943d3dedd
work_keys_str_mv	AT mfraulob quantitativeultrasoundassessmentoftheinfluenceofroughnessandhealingtimeonosseointegrationphenomena AT rvayron quantitativeultrasoundassessmentoftheinfluenceofroughnessandhealingtimeonosseointegrationphenomena AT slecann quantitativeultrasoundassessmentoftheinfluenceofroughnessandhealingtimeonosseointegrationphenomena AT blecuelle quantitativeultrasoundassessmentoftheinfluenceofroughnessandhealingtimeonosseointegrationphenomena AT yheriveaux quantitativeultrasoundassessmentoftheinfluenceofroughnessandhealingtimeonosseointegrationphenomena AT halbinilomami quantitativeultrasoundassessmentoftheinfluenceofroughnessandhealingtimeonosseointegrationphenomena AT chflouzatlachaniette quantitativeultrasoundassessmentoftheinfluenceofroughnessandhealingtimeonosseointegrationphenomena AT ghaiat quantitativeultrasoundassessmentoftheinfluenceofroughnessandhealingtimeonosseointegrationphenomena
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Quantitative ultrasound assessment of the influence of roughness and healing time on osseointegration phenomena

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