The study of the determinants controlling Arpp19 phosphatase-inhibitory activity reveals an Arpp19/PP2A-B55 feedback loop

The study of the determinants controlling Arpp19 phosphatase-inhibitory activity reveals an Arpp19/PP2A-B55 feedback loop

Progression of the cell division cycle requires feedback loops including those of phosphorylation and dephosphorylation; however the precise regulation of phosphorylation kinetics of Arpp19, an inhibitor of protein phosphatase 2A, is unclear. Here, the authors report that feedback between phosphoryl...

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Autores principales: Jean Claude Labbé, Suzanne Vigneron, Francisca Méchali, Perle Robert, Sylvain Roque, Cindy Genoud, Perrine Goguet-Rubio, Phillipe Barthe, Gilles Labesse, Martin Cohen-Gonsaud, Anna Castro, Thierry Lorca
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/4630ed5bbeb04a7d806c2473f1f9022d
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spelling oai:doaj.org-article:4630ed5bbeb04a7d806c2473f1f9022d2021-12-02T17:47:33ZThe study of the determinants controlling Arpp19 phosphatase-inhibitory activity reveals an Arpp19/PP2A-B55 feedback loop10.1038/s41467-021-23657-02041-1723https://doaj.org/article/4630ed5bbeb04a7d806c2473f1f9022d2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23657-0https://doaj.org/toc/2041-1723Progression of the cell division cycle requires feedback loops including those of phosphorylation and dephosphorylation; however the precise regulation of phosphorylation kinetics of Arpp19, an inhibitor of protein phosphatase 2A, is unclear. Here, the authors report that feedback between phosphorylation states of Ser67 and Ser109 of Arpp19 coordinates Arpp19-dependent inhibition of PP2A-B55 and Cyclin B activation during cell cycle progression.Jean Claude LabbéSuzanne VigneronFrancisca MéchaliPerle RobertSylvain RoqueCindy GenoudPerrine Goguet-RubioPhillipe BartheGilles LabesseMartin Cohen-GonsaudAnna CastroThierry LorcaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jean Claude Labbé
Suzanne Vigneron
Francisca Méchali
Perle Robert
Sylvain Roque
Cindy Genoud
Perrine Goguet-Rubio
Phillipe Barthe
Gilles Labesse
Martin Cohen-Gonsaud
Anna Castro
Thierry Lorca
The study of the determinants controlling Arpp19 phosphatase-inhibitory activity reveals an Arpp19/PP2A-B55 feedback loop
description Progression of the cell division cycle requires feedback loops including those of phosphorylation and dephosphorylation; however the precise regulation of phosphorylation kinetics of Arpp19, an inhibitor of protein phosphatase 2A, is unclear. Here, the authors report that feedback between phosphorylation states of Ser67 and Ser109 of Arpp19 coordinates Arpp19-dependent inhibition of PP2A-B55 and Cyclin B activation during cell cycle progression.
format article
author Jean Claude Labbé
Suzanne Vigneron
Francisca Méchali
Perle Robert
Sylvain Roque
Cindy Genoud
Perrine Goguet-Rubio
Phillipe Barthe
Gilles Labesse
Martin Cohen-Gonsaud
Anna Castro
Thierry Lorca
author_facet Jean Claude Labbé
Suzanne Vigneron
Francisca Méchali
Perle Robert
Sylvain Roque
Cindy Genoud
Perrine Goguet-Rubio
Phillipe Barthe
Gilles Labesse
Martin Cohen-Gonsaud
Anna Castro
Thierry Lorca
author_sort Jean Claude Labbé
title The study of the determinants controlling Arpp19 phosphatase-inhibitory activity reveals an Arpp19/PP2A-B55 feedback loop
title_short The study of the determinants controlling Arpp19 phosphatase-inhibitory activity reveals an Arpp19/PP2A-B55 feedback loop
title_full The study of the determinants controlling Arpp19 phosphatase-inhibitory activity reveals an Arpp19/PP2A-B55 feedback loop
title_fullStr The study of the determinants controlling Arpp19 phosphatase-inhibitory activity reveals an Arpp19/PP2A-B55 feedback loop
title_full_unstemmed The study of the determinants controlling Arpp19 phosphatase-inhibitory activity reveals an Arpp19/PP2A-B55 feedback loop
title_sort study of the determinants controlling arpp19 phosphatase-inhibitory activity reveals an arpp19/pp2a-b55 feedback loop
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/4630ed5bbeb04a7d806c2473f1f9022d
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