Zinc oxide nanoparticles using plant Lawsonia inermis and their mosquitocidal, antimicrobial, anticancer applications showing moderate side effects

Abstract Microbes or parasites spread vector-borne diseases by mosquitoes without being affected themselves. Insecticides used in vector control produce a substantial problem for human health. This study synthesized zinc oxide nanoparticles (ZnO NPs) using Lawsonia inermis L. and were characterized...

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Autores principales:	Pandiyan Amuthavalli, Jiang-Shiou Hwang, Hans-Uwe Dahms, Lan Wang, Jagannathan Anitha, Murugan Vasanthakumaran, Arumugam Dhanesh Gandhi, Kadarkarai Murugan, Jayapal Subramaniam, Manickam Paulpandi, Balamurugan Chandramohan, Shivangi Singh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/46311594992c41ad8770e7283312b783
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spelling	oai:doaj.org-article:46311594992c41ad8770e7283312b7832021-12-02T18:27:49ZZinc oxide nanoparticles using plant Lawsonia inermis and their mosquitocidal, antimicrobial, anticancer applications showing moderate side effects10.1038/s41598-021-88164-02045-2322https://doaj.org/article/46311594992c41ad8770e7283312b7832021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88164-0https://doaj.org/toc/2045-2322Abstract Microbes or parasites spread vector-borne diseases by mosquitoes without being affected themselves. Insecticides used in vector control produce a substantial problem for human health. This study synthesized zinc oxide nanoparticles (ZnO NPs) using Lawsonia inermis L. and were characterized by UV–vis, FT-IR, SEM with EDX, and XRD analysis. Green synthesized ZnO NPs were highly toxic against Anopheles stephensi, whose lethal concentrations values ranged from 5.494 ppm (I instar), 6.801 ppm (II instar), 9.336 ppm (III instar), 10.736 ppm (IV instar), and 12.710 ppm (pupae) in contrast to L. inermis treatment. The predation efficiency of the teleost fish Gambusia affinis and the copepod Mesocyclops aspericornis against A. stephensi was not affected by exposure at sublethal doses of ZnO NPs. The predatory potency for G. affinis was 45 (I) and 25.83% (IV), copepod M. aspericornis was 40.66 (I) and 10.8% (IV) while in an ZnO NPs contaminated environment, the predation by the fish G. affinis was boosted to 71.33 and 34.25%, and predation of the copepod M. aspericornis was 60.35 and 16.75%, respectively. ZnO NPs inhibited the growth of several microbial pathogens including the bacteria (Escherichia coli and Bacillus subtilis) and the fungi (Alternaria alternate and Aspergillus flavus), respectively. ZnO NPs decreased the cell viability of Hep-G2 with IC50 value of 21.63 µg/mL (R2 = 0.942; P < 0.001) while the concentration increased from 1.88 to 30 µg/mL. These outcomes support the use of L. inermis mediated ZnO NPs for mosquito control and drug development.Pandiyan AmuthavalliJiang-Shiou HwangHans-Uwe DahmsLan WangJagannathan AnithaMurugan VasanthakumaranArumugam Dhanesh GandhiKadarkarai MuruganJayapal SubramaniamManickam PaulpandiBalamurugan ChandramohanShivangi SinghNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pandiyan Amuthavalli Jiang-Shiou Hwang Hans-Uwe Dahms Lan Wang Jagannathan Anitha Murugan Vasanthakumaran Arumugam Dhanesh Gandhi Kadarkarai Murugan Jayapal Subramaniam Manickam Paulpandi Balamurugan Chandramohan Shivangi Singh Zinc oxide nanoparticles using plant Lawsonia inermis and their mosquitocidal, antimicrobial, anticancer applications showing moderate side effects
description	Abstract Microbes or parasites spread vector-borne diseases by mosquitoes without being affected themselves. Insecticides used in vector control produce a substantial problem for human health. This study synthesized zinc oxide nanoparticles (ZnO NPs) using Lawsonia inermis L. and were characterized by UV–vis, FT-IR, SEM with EDX, and XRD analysis. Green synthesized ZnO NPs were highly toxic against Anopheles stephensi, whose lethal concentrations values ranged from 5.494 ppm (I instar), 6.801 ppm (II instar), 9.336 ppm (III instar), 10.736 ppm (IV instar), and 12.710 ppm (pupae) in contrast to L. inermis treatment. The predation efficiency of the teleost fish Gambusia affinis and the copepod Mesocyclops aspericornis against A. stephensi was not affected by exposure at sublethal doses of ZnO NPs. The predatory potency for G. affinis was 45 (I) and 25.83% (IV), copepod M. aspericornis was 40.66 (I) and 10.8% (IV) while in an ZnO NPs contaminated environment, the predation by the fish G. affinis was boosted to 71.33 and 34.25%, and predation of the copepod M. aspericornis was 60.35 and 16.75%, respectively. ZnO NPs inhibited the growth of several microbial pathogens including the bacteria (Escherichia coli and Bacillus subtilis) and the fungi (Alternaria alternate and Aspergillus flavus), respectively. ZnO NPs decreased the cell viability of Hep-G2 with IC50 value of 21.63 µg/mL (R2 = 0.942; P < 0.001) while the concentration increased from 1.88 to 30 µg/mL. These outcomes support the use of L. inermis mediated ZnO NPs for mosquito control and drug development.
format	article
author	Pandiyan Amuthavalli Jiang-Shiou Hwang Hans-Uwe Dahms Lan Wang Jagannathan Anitha Murugan Vasanthakumaran Arumugam Dhanesh Gandhi Kadarkarai Murugan Jayapal Subramaniam Manickam Paulpandi Balamurugan Chandramohan Shivangi Singh
author_facet	Pandiyan Amuthavalli Jiang-Shiou Hwang Hans-Uwe Dahms Lan Wang Jagannathan Anitha Murugan Vasanthakumaran Arumugam Dhanesh Gandhi Kadarkarai Murugan Jayapal Subramaniam Manickam Paulpandi Balamurugan Chandramohan Shivangi Singh
author_sort	Pandiyan Amuthavalli
title	Zinc oxide nanoparticles using plant Lawsonia inermis and their mosquitocidal, antimicrobial, anticancer applications showing moderate side effects
title_short	Zinc oxide nanoparticles using plant Lawsonia inermis and their mosquitocidal, antimicrobial, anticancer applications showing moderate side effects
title_full	Zinc oxide nanoparticles using plant Lawsonia inermis and their mosquitocidal, antimicrobial, anticancer applications showing moderate side effects
title_fullStr	Zinc oxide nanoparticles using plant Lawsonia inermis and their mosquitocidal, antimicrobial, anticancer applications showing moderate side effects
title_full_unstemmed	Zinc oxide nanoparticles using plant Lawsonia inermis and their mosquitocidal, antimicrobial, anticancer applications showing moderate side effects
title_sort	zinc oxide nanoparticles using plant lawsonia inermis and their mosquitocidal, antimicrobial, anticancer applications showing moderate side effects
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/46311594992c41ad8770e7283312b783
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Zinc oxide nanoparticles using plant Lawsonia inermis and their mosquitocidal, antimicrobial, anticancer applications showing moderate side effects

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