Gene polymorphisms in African buffalo associated with susceptibility to bovine tuberculosis infection.

Bovine tuberculosis (BTB) is a chronic, highly infectious disease that affects humans, cattle and numerous species of wildlife. In developing countries such as South Africa, the existence of extensive wildlife-human-livestock interfaces poses a significant risk of Mycobacterium bovis transmission be...

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Autores principales:	Nikki le Roex, Ad P Koets, Paul D van Helden, Eileen G Hoal
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4638a737aaa441aa977b26fd325a02ef
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spelling	oai:doaj.org-article:4638a737aaa441aa977b26fd325a02ef2021-11-18T07:45:34ZGene polymorphisms in African buffalo associated with susceptibility to bovine tuberculosis infection.1932-620310.1371/journal.pone.0064494https://doaj.org/article/4638a737aaa441aa977b26fd325a02ef2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23691232/?tool=EBIhttps://doaj.org/toc/1932-6203Bovine tuberculosis (BTB) is a chronic, highly infectious disease that affects humans, cattle and numerous species of wildlife. In developing countries such as South Africa, the existence of extensive wildlife-human-livestock interfaces poses a significant risk of Mycobacterium bovis transmission between these groups, and has far-reaching ecological, economic and public health impacts. The African buffalo (Syncerus caffer), acts as a maintenance host for Mycobacterium bovis, and maintains and transmits the disease within the buffalo and to other species. In this study we aimed to investigate genetic susceptibility of buffalo for Mycobacterium bovis infection. Samples from 868 African buffalo of the Cape buffalo subspecies were used in this study. SNPs (n = 69), with predicted functional consequences in genes related to the immune system, were genotyped in this buffalo population by competitive allele-specific SNP genotyping. Case-control association testing and statistical analyses identified three SNPs associated with BTB status in buffalo. These SNPs, SNP41, SNP137 and SNP144, are located in the SLC7A13, DMBT1 and IL1α genes, respectively. SNP137 remained significantly associated after permutation testing. The three genetic polymorphisms identified are located in promising candidate genes for further exploration into genetic susceptibility to BTB in buffalo and other bovids, such as the domestic cow. These polymorphisms/genes may also hold potential for marker-assisted breeding programmes, with the aim of breeding more BTB-resistant animals and herds within both the national parks and the private sector.Nikki le RoexAd P KoetsPaul D van HeldenEileen G HoalPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 5, p e64494 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nikki le Roex Ad P Koets Paul D van Helden Eileen G Hoal Gene polymorphisms in African buffalo associated with susceptibility to bovine tuberculosis infection.
description	Bovine tuberculosis (BTB) is a chronic, highly infectious disease that affects humans, cattle and numerous species of wildlife. In developing countries such as South Africa, the existence of extensive wildlife-human-livestock interfaces poses a significant risk of Mycobacterium bovis transmission between these groups, and has far-reaching ecological, economic and public health impacts. The African buffalo (Syncerus caffer), acts as a maintenance host for Mycobacterium bovis, and maintains and transmits the disease within the buffalo and to other species. In this study we aimed to investigate genetic susceptibility of buffalo for Mycobacterium bovis infection. Samples from 868 African buffalo of the Cape buffalo subspecies were used in this study. SNPs (n = 69), with predicted functional consequences in genes related to the immune system, were genotyped in this buffalo population by competitive allele-specific SNP genotyping. Case-control association testing and statistical analyses identified three SNPs associated with BTB status in buffalo. These SNPs, SNP41, SNP137 and SNP144, are located in the SLC7A13, DMBT1 and IL1α genes, respectively. SNP137 remained significantly associated after permutation testing. The three genetic polymorphisms identified are located in promising candidate genes for further exploration into genetic susceptibility to BTB in buffalo and other bovids, such as the domestic cow. These polymorphisms/genes may also hold potential for marker-assisted breeding programmes, with the aim of breeding more BTB-resistant animals and herds within both the national parks and the private sector.
format	article
author	Nikki le Roex Ad P Koets Paul D van Helden Eileen G Hoal
author_facet	Nikki le Roex Ad P Koets Paul D van Helden Eileen G Hoal
author_sort	Nikki le Roex
title	Gene polymorphisms in African buffalo associated with susceptibility to bovine tuberculosis infection.
title_short	Gene polymorphisms in African buffalo associated with susceptibility to bovine tuberculosis infection.
title_full	Gene polymorphisms in African buffalo associated with susceptibility to bovine tuberculosis infection.
title_fullStr	Gene polymorphisms in African buffalo associated with susceptibility to bovine tuberculosis infection.
title_full_unstemmed	Gene polymorphisms in African buffalo associated with susceptibility to bovine tuberculosis infection.
title_sort	gene polymorphisms in african buffalo associated with susceptibility to bovine tuberculosis infection.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/4638a737aaa441aa977b26fd325a02ef
work_keys_str_mv	AT nikkileroex genepolymorphismsinafricanbuffaloassociatedwithsusceptibilitytobovinetuberculosisinfection AT adpkoets genepolymorphismsinafricanbuffaloassociatedwithsusceptibilitytobovinetuberculosisinfection AT pauldvanhelden genepolymorphismsinafricanbuffaloassociatedwithsusceptibilitytobovinetuberculosisinfection AT eileenghoal genepolymorphismsinafricanbuffaloassociatedwithsusceptibilitytobovinetuberculosisinfection
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Gene polymorphisms in African buffalo associated with susceptibility to bovine tuberculosis infection.

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