The nasal methylome as a biomarker of asthma and airway inflammation in children

The nasal methylome as a biomarker of asthma and airway inflammation in children

Epigenetic differences in nasal epithelium have been proposed as a biomarker for lower airway disease and asthma. Here, in epigenome-wide association studies for asthma and other airway traits using nasal swabs, the authors identify differentially methylated CpGs that highlight genes involved in TH2...

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Autores principales: Andres Cardenas, Joanne E. Sordillo, Sheryl L. Rifas-Shiman, Wonil Chung, Liming Liang, Brent A. Coull, Marie-France Hivert, Peggy S. Lai, Erick Forno, Juan C. Celedón, Augusto A. Litonjua, Kasey J. Brennan, Dawn L. DeMeo, Andrea A. Baccarelli, Emily Oken, Diane R. Gold
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Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/463a3a6559c24a0d94c1e260b9956f71
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spelling oai:doaj.org-article:463a3a6559c24a0d94c1e260b9956f712021-12-02T17:02:11ZThe nasal methylome as a biomarker of asthma and airway inflammation in children10.1038/s41467-019-11058-32041-1723https://doaj.org/article/463a3a6559c24a0d94c1e260b9956f712019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11058-3https://doaj.org/toc/2041-1723Epigenetic differences in nasal epithelium have been proposed as a biomarker for lower airway disease and asthma. Here, in epigenome-wide association studies for asthma and other airway traits using nasal swabs, the authors identify differentially methylated CpGs that highlight genes involved in TH2 response.Andres CardenasJoanne E. SordilloSheryl L. Rifas-ShimanWonil ChungLiming LiangBrent A. CoullMarie-France HivertPeggy S. LaiErick FornoJuan C. CeledónAugusto A. LitonjuaKasey J. BrennanDawn L. DeMeoAndrea A. BaccarelliEmily OkenDiane R. GoldNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Andres Cardenas
Joanne E. Sordillo
Sheryl L. Rifas-Shiman
Wonil Chung
Liming Liang
Brent A. Coull
Marie-France Hivert
Peggy S. Lai
Erick Forno
Juan C. Celedón
Augusto A. Litonjua
Kasey J. Brennan
Dawn L. DeMeo
Andrea A. Baccarelli
Emily Oken
Diane R. Gold
The nasal methylome as a biomarker of asthma and airway inflammation in children
description Epigenetic differences in nasal epithelium have been proposed as a biomarker for lower airway disease and asthma. Here, in epigenome-wide association studies for asthma and other airway traits using nasal swabs, the authors identify differentially methylated CpGs that highlight genes involved in TH2 response.
format article
author Andres Cardenas
Joanne E. Sordillo
Sheryl L. Rifas-Shiman
Wonil Chung
Liming Liang
Brent A. Coull
Marie-France Hivert
Peggy S. Lai
Erick Forno
Juan C. Celedón
Augusto A. Litonjua
Kasey J. Brennan
Dawn L. DeMeo
Andrea A. Baccarelli
Emily Oken
Diane R. Gold
author_facet Andres Cardenas
Joanne E. Sordillo
Sheryl L. Rifas-Shiman
Wonil Chung
Liming Liang
Brent A. Coull
Marie-France Hivert
Peggy S. Lai
Erick Forno
Juan C. Celedón
Augusto A. Litonjua
Kasey J. Brennan
Dawn L. DeMeo
Andrea A. Baccarelli
Emily Oken
Diane R. Gold
author_sort Andres Cardenas
title The nasal methylome as a biomarker of asthma and airway inflammation in children
title_short The nasal methylome as a biomarker of asthma and airway inflammation in children
title_full The nasal methylome as a biomarker of asthma and airway inflammation in children
title_fullStr The nasal methylome as a biomarker of asthma and airway inflammation in children
title_full_unstemmed The nasal methylome as a biomarker of asthma and airway inflammation in children
title_sort nasal methylome as a biomarker of asthma and airway inflammation in children
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/463a3a6559c24a0d94c1e260b9956f71
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