Eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptor
Dowsett and colleagues used a genome-wide association approach to investigate the genetic influence on soluble urokinase-type plasminogen activator receptor presence in the plasma of humans. Their findings indicate a 60% heritability factor in British twins, and using a wide sample of Northern Europ...
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Nature Portfolio
2021
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oai:doaj.org-article:463a8f996b614aa094ac078c66f08ee52021-12-02T15:02:56ZEleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptor10.1038/s42003-021-02144-82399-3642https://doaj.org/article/463a8f996b614aa094ac078c66f08ee52021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02144-8https://doaj.org/toc/2399-3642Dowsett and colleagues used a genome-wide association approach to investigate the genetic influence on soluble urokinase-type plasminogen activator receptor presence in the plasma of humans. Their findings indicate a 60% heritability factor in British twins, and using a wide sample of Northern European genome samples they identify eleven genetic loci associated with an increase or decrease of this chronic inflammation marker.Joseph DowsettEgil FerkingstadLine Jee Hartmann RasmussenLise Wegner ThørnerMagnús K. MagnússonKaren SugdenGudmar ThorleifssonMike FriggeKristoffer Sølvsten BurgdorfSisse Rye OstrowskiErik SørensenChristian ErikstrupOle Birger PedersenThomas Folkmann HansenKarina BanasikSøren BrunakDBDS Genomic ConsortiumVinicius TraganteSigrun Helga LundLilja StefansdottirBjarni GunnarsonRichie PoultonLouise ArseneaultAvshalom CaspiTerrie E. MoffittDaníel GudbjartssonJesper Eugen-OlsenHreinn StefánssonKári StefánssonHenrik UllumNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Biology (General) QH301-705.5 |
| spellingShingle |
Biology (General) QH301-705.5 Joseph Dowsett Egil Ferkingstad Line Jee Hartmann Rasmussen Lise Wegner Thørner Magnús K. Magnússon Karen Sugden Gudmar Thorleifsson Mike Frigge Kristoffer Sølvsten Burgdorf Sisse Rye Ostrowski Erik Sørensen Christian Erikstrup Ole Birger Pedersen Thomas Folkmann Hansen Karina Banasik Søren Brunak DBDS Genomic Consortium Vinicius Tragante Sigrun Helga Lund Lilja Stefansdottir Bjarni Gunnarson Richie Poulton Louise Arseneault Avshalom Caspi Terrie E. Moffitt Daníel Gudbjartsson Jesper Eugen-Olsen Hreinn Stefánsson Kári Stefánsson Henrik Ullum Eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptor |
| description |
Dowsett and colleagues used a genome-wide association approach to investigate the genetic influence on soluble urokinase-type plasminogen activator receptor presence in the plasma of humans. Their findings indicate a 60% heritability factor in British twins, and using a wide sample of Northern European genome samples they identify eleven genetic loci associated with an increase or decrease of this chronic inflammation marker. |
| format |
article |
| author |
Joseph Dowsett Egil Ferkingstad Line Jee Hartmann Rasmussen Lise Wegner Thørner Magnús K. Magnússon Karen Sugden Gudmar Thorleifsson Mike Frigge Kristoffer Sølvsten Burgdorf Sisse Rye Ostrowski Erik Sørensen Christian Erikstrup Ole Birger Pedersen Thomas Folkmann Hansen Karina Banasik Søren Brunak DBDS Genomic Consortium Vinicius Tragante Sigrun Helga Lund Lilja Stefansdottir Bjarni Gunnarson Richie Poulton Louise Arseneault Avshalom Caspi Terrie E. Moffitt Daníel Gudbjartsson Jesper Eugen-Olsen Hreinn Stefánsson Kári Stefánsson Henrik Ullum |
| author_facet |
Joseph Dowsett Egil Ferkingstad Line Jee Hartmann Rasmussen Lise Wegner Thørner Magnús K. Magnússon Karen Sugden Gudmar Thorleifsson Mike Frigge Kristoffer Sølvsten Burgdorf Sisse Rye Ostrowski Erik Sørensen Christian Erikstrup Ole Birger Pedersen Thomas Folkmann Hansen Karina Banasik Søren Brunak DBDS Genomic Consortium Vinicius Tragante Sigrun Helga Lund Lilja Stefansdottir Bjarni Gunnarson Richie Poulton Louise Arseneault Avshalom Caspi Terrie E. Moffitt Daníel Gudbjartsson Jesper Eugen-Olsen Hreinn Stefánsson Kári Stefánsson Henrik Ullum |
| author_sort |
Joseph Dowsett |
| title |
Eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptor |
| title_short |
Eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptor |
| title_full |
Eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptor |
| title_fullStr |
Eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptor |
| title_full_unstemmed |
Eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptor |
| title_sort |
eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptor |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/463a8f996b614aa094ac078c66f08ee5 |
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