Mir20a/106a-WTX axis regulates RhoGDIa/CDC42 signaling and colon cancer progression

Mir20a/106a-WTX axis regulates RhoGDIa/CDC42 signaling and colon cancer progression

Wilms tumor gene on the X chromosome (WTX) is commonly downregulated in human cancers. Here the authors show that in colorectal cancer (CRC) WTX expression is downregulated via miR20a and miR160a and its loss promotes tumor development and liver metastasis by disrupting the interaction between RhoGD...

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Autores principales: Gui-fang Zhu, Yang-wei Xu, Jian Li, Hui-lin Niu, Wen-xia Ma, Jia Xu, Pei-rong Zhou, Xia Liu, Dan-li Ye, Xiao-rong Liu, Tao Yan, Wei-ke Zhai, Zhi-jun Xu, Chun Liu, Lei Wang, Hao Wang, Jia-mao Luo, Li Liu, Xuan-qi Li, Suiqun Guo, Hui-ping Jiang, Peng Shen, Hui-kuan Lin, Di-hua Yu, Yan-qing Ding, Qing-ling Zhang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/463b1bf66bc94285b4f947bc3989465f
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spelling oai:doaj.org-article:463b1bf66bc94285b4f947bc3989465f2021-12-02T15:35:31ZMir20a/106a-WTX axis regulates RhoGDIa/CDC42 signaling and colon cancer progression10.1038/s41467-018-07998-x2041-1723https://doaj.org/article/463b1bf66bc94285b4f947bc3989465f2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07998-xhttps://doaj.org/toc/2041-1723Wilms tumor gene on the X chromosome (WTX) is commonly downregulated in human cancers. Here the authors show that in colorectal cancer (CRC) WTX expression is downregulated via miR20a and miR160a and its loss promotes tumor development and liver metastasis by disrupting the interaction between RhoGDIα and CDC42 leading to the activation of the CDC42 downstream cascades.Gui-fang ZhuYang-wei XuJian LiHui-lin NiuWen-xia MaJia XuPei-rong ZhouXia LiuDan-li YeXiao-rong LiuTao YanWei-ke ZhaiZhi-jun XuChun LiuLei WangHao WangJia-mao LuoLi LiuXuan-qi LiSuiqun GuoHui-ping JiangPeng ShenHui-kuan LinDi-hua YuYan-qing DingQing-ling ZhangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Gui-fang Zhu
Yang-wei Xu
Jian Li
Hui-lin Niu
Wen-xia Ma
Jia Xu
Pei-rong Zhou
Xia Liu
Dan-li Ye
Xiao-rong Liu
Tao Yan
Wei-ke Zhai
Zhi-jun Xu
Chun Liu
Lei Wang
Hao Wang
Jia-mao Luo
Li Liu
Xuan-qi Li
Suiqun Guo
Hui-ping Jiang
Peng Shen
Hui-kuan Lin
Di-hua Yu
Yan-qing Ding
Qing-ling Zhang
Mir20a/106a-WTX axis regulates RhoGDIa/CDC42 signaling and colon cancer progression
description Wilms tumor gene on the X chromosome (WTX) is commonly downregulated in human cancers. Here the authors show that in colorectal cancer (CRC) WTX expression is downregulated via miR20a and miR160a and its loss promotes tumor development and liver metastasis by disrupting the interaction between RhoGDIα and CDC42 leading to the activation of the CDC42 downstream cascades.
format article
author Gui-fang Zhu
Yang-wei Xu
Jian Li
Hui-lin Niu
Wen-xia Ma
Jia Xu
Pei-rong Zhou
Xia Liu
Dan-li Ye
Xiao-rong Liu
Tao Yan
Wei-ke Zhai
Zhi-jun Xu
Chun Liu
Lei Wang
Hao Wang
Jia-mao Luo
Li Liu
Xuan-qi Li
Suiqun Guo
Hui-ping Jiang
Peng Shen
Hui-kuan Lin
Di-hua Yu
Yan-qing Ding
Qing-ling Zhang
author_facet Gui-fang Zhu
Yang-wei Xu
Jian Li
Hui-lin Niu
Wen-xia Ma
Jia Xu
Pei-rong Zhou
Xia Liu
Dan-li Ye
Xiao-rong Liu
Tao Yan
Wei-ke Zhai
Zhi-jun Xu
Chun Liu
Lei Wang
Hao Wang
Jia-mao Luo
Li Liu
Xuan-qi Li
Suiqun Guo
Hui-ping Jiang
Peng Shen
Hui-kuan Lin
Di-hua Yu
Yan-qing Ding
Qing-ling Zhang
author_sort Gui-fang Zhu
title Mir20a/106a-WTX axis regulates RhoGDIa/CDC42 signaling and colon cancer progression
title_short Mir20a/106a-WTX axis regulates RhoGDIa/CDC42 signaling and colon cancer progression
title_full Mir20a/106a-WTX axis regulates RhoGDIa/CDC42 signaling and colon cancer progression
title_fullStr Mir20a/106a-WTX axis regulates RhoGDIa/CDC42 signaling and colon cancer progression
title_full_unstemmed Mir20a/106a-WTX axis regulates RhoGDIa/CDC42 signaling and colon cancer progression
title_sort mir20a/106a-wtx axis regulates rhogdia/cdc42 signaling and colon cancer progression
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/463b1bf66bc94285b4f947bc3989465f
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