Orthogonal Cas9–Cas9 chimeras provide a versatile platform for genome editing

Therapeutic genome engineering relies on the development of reliable, robust and versatile tools. Here the authors develop Cas9-Cas9 chimeras with high target site activity that generate predictable deletions.

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Autores principales: Mehmet Fatih Bolukbasi, Pengpeng Liu, Kevin Luk, Samantha F. Kwok, Ankit Gupta, Nadia Amrani, Erik J. Sontheimer, Lihua Julie Zhu, Scot A. Wolfe
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/463e5b127556499185f48ce65924481b
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spelling oai:doaj.org-article:463e5b127556499185f48ce65924481b2021-12-02T15:34:43ZOrthogonal Cas9–Cas9 chimeras provide a versatile platform for genome editing10.1038/s41467-018-07310-x2041-1723https://doaj.org/article/463e5b127556499185f48ce65924481b2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07310-xhttps://doaj.org/toc/2041-1723Therapeutic genome engineering relies on the development of reliable, robust and versatile tools. Here the authors develop Cas9-Cas9 chimeras with high target site activity that generate predictable deletions.Mehmet Fatih BolukbasiPengpeng LiuKevin LukSamantha F. KwokAnkit GuptaNadia AmraniErik J. SontheimerLihua Julie ZhuScot A. WolfeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Mehmet Fatih Bolukbasi
Pengpeng Liu
Kevin Luk
Samantha F. Kwok
Ankit Gupta
Nadia Amrani
Erik J. Sontheimer
Lihua Julie Zhu
Scot A. Wolfe
Orthogonal Cas9–Cas9 chimeras provide a versatile platform for genome editing
description Therapeutic genome engineering relies on the development of reliable, robust and versatile tools. Here the authors develop Cas9-Cas9 chimeras with high target site activity that generate predictable deletions.
format article
author Mehmet Fatih Bolukbasi
Pengpeng Liu
Kevin Luk
Samantha F. Kwok
Ankit Gupta
Nadia Amrani
Erik J. Sontheimer
Lihua Julie Zhu
Scot A. Wolfe
author_facet Mehmet Fatih Bolukbasi
Pengpeng Liu
Kevin Luk
Samantha F. Kwok
Ankit Gupta
Nadia Amrani
Erik J. Sontheimer
Lihua Julie Zhu
Scot A. Wolfe
author_sort Mehmet Fatih Bolukbasi
title Orthogonal Cas9–Cas9 chimeras provide a versatile platform for genome editing
title_short Orthogonal Cas9–Cas9 chimeras provide a versatile platform for genome editing
title_full Orthogonal Cas9–Cas9 chimeras provide a versatile platform for genome editing
title_fullStr Orthogonal Cas9–Cas9 chimeras provide a versatile platform for genome editing
title_full_unstemmed Orthogonal Cas9–Cas9 chimeras provide a versatile platform for genome editing
title_sort orthogonal cas9–cas9 chimeras provide a versatile platform for genome editing
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/463e5b127556499185f48ce65924481b
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