NRF2 Activation and Downstream Effects: Focus on Parkinson’s Disease and Brain Angiotensin

Reactive oxygen species (ROS) are signalling molecules used to regulate cellular metabolism and homeostasis. However, excessive ROS production causes oxidative stress, one of the main mechanisms associated with the origin and progression of neurodegenerative disorders such as Parkinson’s disease. NR...

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Autores principales:	Juan A. Parga, Ana I. Rodriguez-Perez, Maria Garcia-Garrote, Jannette Rodriguez-Pallares, Jose L. Labandeira-Garcia
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	NRF2 antioxidant heme oxygenase KLF9 neurodegeneration Parkinson’s disease Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/463e6b227e944cbeaef996be550f6b50
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spelling	oai:doaj.org-article:463e6b227e944cbeaef996be550f6b502021-11-25T16:25:19ZNRF2 Activation and Downstream Effects: Focus on Parkinson’s Disease and Brain Angiotensin10.3390/antiox101116492076-3921https://doaj.org/article/463e6b227e944cbeaef996be550f6b502021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3921/10/11/1649https://doaj.org/toc/2076-3921Reactive oxygen species (ROS) are signalling molecules used to regulate cellular metabolism and homeostasis. However, excessive ROS production causes oxidative stress, one of the main mechanisms associated with the origin and progression of neurodegenerative disorders such as Parkinson’s disease. NRF2 (Nuclear Factor-Erythroid 2 Like 2) is a transcription factor that orchestrates the cellular response to oxidative stress. The regulation of NRF2 signalling has been shown to be a promising strategy to modulate the progression of the neurodegeneration associated to Parkinson’s disease. The NRF2 pathway has been shown to be affected in patients with this disease, and activation of NRF2 has neuroprotective effects in preclinical models, demonstrating the therapeutic potential of this pathway. In this review, we highlight recent advances regarding the regulation of NRF2, including the effect of Angiotensin II as an endogenous signalling molecule able to regulate ROS production and oxidative stress in dopaminergic neurons. The genes regulated and the downstream effects of activation, with special focus on Kruppel Like Factor 9 (KLF9) transcription factor, provide clues about the mechanisms involved in the neurodegenerative process as well as future therapeutic approaches.Juan A. PargaAna I. Rodriguez-PerezMaria Garcia-GarroteJannette Rodriguez-PallaresJose L. Labandeira-GarciaMDPI AGarticleNRF2antioxidantheme oxygenaseKLF9neurodegenerationParkinson’s diseaseTherapeutics. PharmacologyRM1-950ENAntioxidants, Vol 10, Iss 1649, p 1649 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	NRF2 antioxidant heme oxygenase KLF9 neurodegeneration Parkinson’s disease Therapeutics. Pharmacology RM1-950
spellingShingle	NRF2 antioxidant heme oxygenase KLF9 neurodegeneration Parkinson’s disease Therapeutics. Pharmacology RM1-950 Juan A. Parga Ana I. Rodriguez-Perez Maria Garcia-Garrote Jannette Rodriguez-Pallares Jose L. Labandeira-Garcia NRF2 Activation and Downstream Effects: Focus on Parkinson’s Disease and Brain Angiotensin
description	Reactive oxygen species (ROS) are signalling molecules used to regulate cellular metabolism and homeostasis. However, excessive ROS production causes oxidative stress, one of the main mechanisms associated with the origin and progression of neurodegenerative disorders such as Parkinson’s disease. NRF2 (Nuclear Factor-Erythroid 2 Like 2) is a transcription factor that orchestrates the cellular response to oxidative stress. The regulation of NRF2 signalling has been shown to be a promising strategy to modulate the progression of the neurodegeneration associated to Parkinson’s disease. The NRF2 pathway has been shown to be affected in patients with this disease, and activation of NRF2 has neuroprotective effects in preclinical models, demonstrating the therapeutic potential of this pathway. In this review, we highlight recent advances regarding the regulation of NRF2, including the effect of Angiotensin II as an endogenous signalling molecule able to regulate ROS production and oxidative stress in dopaminergic neurons. The genes regulated and the downstream effects of activation, with special focus on Kruppel Like Factor 9 (KLF9) transcription factor, provide clues about the mechanisms involved in the neurodegenerative process as well as future therapeutic approaches.
format	article
author	Juan A. Parga Ana I. Rodriguez-Perez Maria Garcia-Garrote Jannette Rodriguez-Pallares Jose L. Labandeira-Garcia
author_facet	Juan A. Parga Ana I. Rodriguez-Perez Maria Garcia-Garrote Jannette Rodriguez-Pallares Jose L. Labandeira-Garcia
author_sort	Juan A. Parga
title	NRF2 Activation and Downstream Effects: Focus on Parkinson’s Disease and Brain Angiotensin
title_short	NRF2 Activation and Downstream Effects: Focus on Parkinson’s Disease and Brain Angiotensin
title_full	NRF2 Activation and Downstream Effects: Focus on Parkinson’s Disease and Brain Angiotensin
title_fullStr	NRF2 Activation and Downstream Effects: Focus on Parkinson’s Disease and Brain Angiotensin
title_full_unstemmed	NRF2 Activation and Downstream Effects: Focus on Parkinson’s Disease and Brain Angiotensin
title_sort	nrf2 activation and downstream effects: focus on parkinson’s disease and brain angiotensin
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/463e6b227e944cbeaef996be550f6b50
work_keys_str_mv	AT juanaparga nrf2activationanddownstreameffectsfocusonparkinsonsdiseaseandbrainangiotensin AT anairodriguezperez nrf2activationanddownstreameffectsfocusonparkinsonsdiseaseandbrainangiotensin AT mariagarciagarrote nrf2activationanddownstreameffectsfocusonparkinsonsdiseaseandbrainangiotensin AT jannetterodriguezpallares nrf2activationanddownstreameffectsfocusonparkinsonsdiseaseandbrainangiotensin AT josellabandeiragarcia nrf2activationanddownstreameffectsfocusonparkinsonsdiseaseandbrainangiotensin
_version_	1718413195846090752

NRF2 Activation and Downstream Effects: Focus on Parkinson’s Disease and Brain Angiotensin

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