Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly

Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly

Ageing is associated with a pronounced shift in mortality from cancer to degenerative diseases. Here, the authors show that in concordance with this shift, conserved transcriptional alterations during ageing across four vertebrates align with degenerative diseases but are opposite to those in cancer...

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Autores principales: Peer Aramillo Irizar, Sascha Schäuble, Daniela Esser, Marco Groth, Christiane Frahm, Steffen Priebe, Mario Baumgart, Nils Hartmann, Shiva Marthandan, Uwe Menzel, Jule Müller, Silvio Schmidt, Volker Ast, Amke Caliebe, Rainer König, Michael Krawczak, Michael Ristow, Stefan Schuster, Alessandro Cellerino, Stephan Diekmann, Christoph Englert, Peter Hemmerich, Jürgen Sühnel, Reinhard Guthke, Otto W. Witte, Matthias Platzer, Eytan Ruppin, Christoph Kaleta
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/463f3bfceed14b74b71020ee1edcf215
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spelling oai:doaj.org-article:463f3bfceed14b74b71020ee1edcf2152021-12-02T13:24:24ZTranscriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly10.1038/s41467-017-02395-22041-1723https://doaj.org/article/463f3bfceed14b74b71020ee1edcf2152018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02395-2https://doaj.org/toc/2041-1723Ageing is associated with a pronounced shift in mortality from cancer to degenerative diseases. Here, the authors show that in concordance with this shift, conserved transcriptional alterations during ageing across four vertebrates align with degenerative diseases but are opposite to those in cancer.Peer Aramillo IrizarSascha SchäubleDaniela EsserMarco GrothChristiane FrahmSteffen PriebeMario BaumgartNils HartmannShiva MarthandanUwe MenzelJule MüllerSilvio SchmidtVolker AstAmke CaliebeRainer KönigMichael KrawczakMichael RistowStefan SchusterAlessandro CellerinoStephan DiekmannChristoph EnglertPeter HemmerichJürgen SühnelReinhard GuthkeOtto W. WitteMatthias PlatzerEytan RuppinChristoph KaletaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Peer Aramillo Irizar
Sascha Schäuble
Daniela Esser
Marco Groth
Christiane Frahm
Steffen Priebe
Mario Baumgart
Nils Hartmann
Shiva Marthandan
Uwe Menzel
Jule Müller
Silvio Schmidt
Volker Ast
Amke Caliebe
Rainer König
Michael Krawczak
Michael Ristow
Stefan Schuster
Alessandro Cellerino
Stephan Diekmann
Christoph Englert
Peter Hemmerich
Jürgen Sühnel
Reinhard Guthke
Otto W. Witte
Matthias Platzer
Eytan Ruppin
Christoph Kaleta
Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly
description Ageing is associated with a pronounced shift in mortality from cancer to degenerative diseases. Here, the authors show that in concordance with this shift, conserved transcriptional alterations during ageing across four vertebrates align with degenerative diseases but are opposite to those in cancer.
format article
author Peer Aramillo Irizar
Sascha Schäuble
Daniela Esser
Marco Groth
Christiane Frahm
Steffen Priebe
Mario Baumgart
Nils Hartmann
Shiva Marthandan
Uwe Menzel
Jule Müller
Silvio Schmidt
Volker Ast
Amke Caliebe
Rainer König
Michael Krawczak
Michael Ristow
Stefan Schuster
Alessandro Cellerino
Stephan Diekmann
Christoph Englert
Peter Hemmerich
Jürgen Sühnel
Reinhard Guthke
Otto W. Witte
Matthias Platzer
Eytan Ruppin
Christoph Kaleta
author_facet Peer Aramillo Irizar
Sascha Schäuble
Daniela Esser
Marco Groth
Christiane Frahm
Steffen Priebe
Mario Baumgart
Nils Hartmann
Shiva Marthandan
Uwe Menzel
Jule Müller
Silvio Schmidt
Volker Ast
Amke Caliebe
Rainer König
Michael Krawczak
Michael Ristow
Stefan Schuster
Alessandro Cellerino
Stephan Diekmann
Christoph Englert
Peter Hemmerich
Jürgen Sühnel
Reinhard Guthke
Otto W. Witte
Matthias Platzer
Eytan Ruppin
Christoph Kaleta
author_sort Peer Aramillo Irizar
title Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly
title_short Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly
title_full Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly
title_fullStr Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly
title_full_unstemmed Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly
title_sort transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/463f3bfceed14b74b71020ee1edcf215
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