Dosimetric Optimization of a Laser-Driven Irradiation Facility Using the G4-ELIMED Application

ELIMED has been developed and installed at ELI beamlines as a part of the ELIMAIA beamline to transport, monitor, and use laser-driven ion beams suitable for multidisciplinary applications, including biomedical ones. This paper aims to investigate the feasibility to perform radiobiological experimen...

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Autores principales:	Sergio Mingo Barba, Francesco Schillaci, Roberto Catalano, Giada Petringa, Daniele Margarone, Giuseppe Antonio Pablo Cirrone
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Monte Carlo simulations Geant4 laser-accelerated ion beams Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/46477ef04f0944079b685b3f0e90808e
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id	oai:doaj.org-article:46477ef04f0944079b685b3f0e90808e
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spelling	oai:doaj.org-article:46477ef04f0944079b685b3f0e90808e2021-11-11T14:58:10ZDosimetric Optimization of a Laser-Driven Irradiation Facility Using the G4-ELIMED Application10.3390/app112198232076-3417https://doaj.org/article/46477ef04f0944079b685b3f0e90808e2021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3417/11/21/9823https://doaj.org/toc/2076-3417ELIMED has been developed and installed at ELI beamlines as a part of the ELIMAIA beamline to transport, monitor, and use laser-driven ion beams suitable for multidisciplinary applications, including biomedical ones. This paper aims to investigate the feasibility to perform radiobiological experiments using laser-accelerated proton beams with intermediate energies (up to 30 MeV). To reach this goal, we simulate a proton source based on experimental data like the ones expected to be available in the first phase of ELIMED commissioning by using the G4-ELIMED application (an application based on the Geant4 toolkit that simulates the full ELIMED beamline). This allows the study of transmission efficiency and the final characteristics of the proton beam at the sample irradiation point. The Energy Selector System is used as an active energy modulator to obtain the desired beam features in a relatively short irradiation time (around 6 min). Furthermore, we demonstrate the capability of the beamline to filter out other ion contaminants, typically co-accelerated in a laser-plasma environment. These results can be considered as a detailed feasibility study for the use of ELIMED for various user applications such as radiobiological experiments with ultrahigh dose rate proton beams.Sergio Mingo BarbaFrancesco SchillaciRoberto CatalanoGiada PetringaDaniele MargaroneGiuseppe Antonio Pablo CirroneMDPI AGarticleMonte Carlo simulationsGeant4laser-accelerated ion beamsTechnologyTEngineering (General). Civil engineering (General)TA1-2040Biology (General)QH301-705.5PhysicsQC1-999ChemistryQD1-999ENApplied Sciences, Vol 11, Iss 9823, p 9823 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Monte Carlo simulations Geant4 laser-accelerated ion beams Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
spellingShingle	Monte Carlo simulations Geant4 laser-accelerated ion beams Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999 Sergio Mingo Barba Francesco Schillaci Roberto Catalano Giada Petringa Daniele Margarone Giuseppe Antonio Pablo Cirrone Dosimetric Optimization of a Laser-Driven Irradiation Facility Using the G4-ELIMED Application
description	ELIMED has been developed and installed at ELI beamlines as a part of the ELIMAIA beamline to transport, monitor, and use laser-driven ion beams suitable for multidisciplinary applications, including biomedical ones. This paper aims to investigate the feasibility to perform radiobiological experiments using laser-accelerated proton beams with intermediate energies (up to 30 MeV). To reach this goal, we simulate a proton source based on experimental data like the ones expected to be available in the first phase of ELIMED commissioning by using the G4-ELIMED application (an application based on the Geant4 toolkit that simulates the full ELIMED beamline). This allows the study of transmission efficiency and the final characteristics of the proton beam at the sample irradiation point. The Energy Selector System is used as an active energy modulator to obtain the desired beam features in a relatively short irradiation time (around 6 min). Furthermore, we demonstrate the capability of the beamline to filter out other ion contaminants, typically co-accelerated in a laser-plasma environment. These results can be considered as a detailed feasibility study for the use of ELIMED for various user applications such as radiobiological experiments with ultrahigh dose rate proton beams.
format	article
author	Sergio Mingo Barba Francesco Schillaci Roberto Catalano Giada Petringa Daniele Margarone Giuseppe Antonio Pablo Cirrone
author_facet	Sergio Mingo Barba Francesco Schillaci Roberto Catalano Giada Petringa Daniele Margarone Giuseppe Antonio Pablo Cirrone
author_sort	Sergio Mingo Barba
title	Dosimetric Optimization of a Laser-Driven Irradiation Facility Using the G4-ELIMED Application
title_short	Dosimetric Optimization of a Laser-Driven Irradiation Facility Using the G4-ELIMED Application
title_full	Dosimetric Optimization of a Laser-Driven Irradiation Facility Using the G4-ELIMED Application
title_fullStr	Dosimetric Optimization of a Laser-Driven Irradiation Facility Using the G4-ELIMED Application
title_full_unstemmed	Dosimetric Optimization of a Laser-Driven Irradiation Facility Using the G4-ELIMED Application
title_sort	dosimetric optimization of a laser-driven irradiation facility using the g4-elimed application
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/46477ef04f0944079b685b3f0e90808e
work_keys_str_mv	AT sergiomingobarba dosimetricoptimizationofalaserdrivenirradiationfacilityusingtheg4elimedapplication AT francescoschillaci dosimetricoptimizationofalaserdrivenirradiationfacilityusingtheg4elimedapplication AT robertocatalano dosimetricoptimizationofalaserdrivenirradiationfacilityusingtheg4elimedapplication AT giadapetringa dosimetricoptimizationofalaserdrivenirradiationfacilityusingtheg4elimedapplication AT danielemargarone dosimetricoptimizationofalaserdrivenirradiationfacilityusingtheg4elimedapplication AT giuseppeantoniopablocirrone dosimetricoptimizationofalaserdrivenirradiationfacilityusingtheg4elimedapplication
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Dosimetric Optimization of a Laser-Driven Irradiation Facility Using the G4-ELIMED Application

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