Nucleoporin 153 links nuclear pore complex to chromatin architecture by mediating CTCF and cohesin binding

The nuclear pore complex components, nucleoporins, have been proposed to mediate spatial and temporal organization of chromatin. Here, the authors show that Nucleoporin 153 interacts with CTCF and cohesin, and mediates their binding across cis-regulatory elements and TAD boundaries in mouse embryoni...

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Autores principales:	Shinichi Kadota, Jianhong Ou, Yuming Shi, Jeannie T. Lee, Jiayu Sun, Eda Yildirim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4648e84dd657468790c7182b423f1e5e
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spelling	oai:doaj.org-article:4648e84dd657468790c7182b423f1e5e2021-12-02T15:49:49ZNucleoporin 153 links nuclear pore complex to chromatin architecture by mediating CTCF and cohesin binding10.1038/s41467-020-16394-32041-1723https://doaj.org/article/4648e84dd657468790c7182b423f1e5e2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16394-3https://doaj.org/toc/2041-1723The nuclear pore complex components, nucleoporins, have been proposed to mediate spatial and temporal organization of chromatin. Here, the authors show that Nucleoporin 153 interacts with CTCF and cohesin, and mediates their binding across cis-regulatory elements and TAD boundaries in mouse embryonic stem cells.Shinichi KadotaJianhong OuYuming ShiJeannie T. LeeJiayu SunEda YildirimNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shinichi Kadota Jianhong Ou Yuming Shi Jeannie T. Lee Jiayu Sun Eda Yildirim Nucleoporin 153 links nuclear pore complex to chromatin architecture by mediating CTCF and cohesin binding
description	The nuclear pore complex components, nucleoporins, have been proposed to mediate spatial and temporal organization of chromatin. Here, the authors show that Nucleoporin 153 interacts with CTCF and cohesin, and mediates their binding across cis-regulatory elements and TAD boundaries in mouse embryonic stem cells.
format	article
author	Shinichi Kadota Jianhong Ou Yuming Shi Jeannie T. Lee Jiayu Sun Eda Yildirim
author_facet	Shinichi Kadota Jianhong Ou Yuming Shi Jeannie T. Lee Jiayu Sun Eda Yildirim
author_sort	Shinichi Kadota
title	Nucleoporin 153 links nuclear pore complex to chromatin architecture by mediating CTCF and cohesin binding
title_short	Nucleoporin 153 links nuclear pore complex to chromatin architecture by mediating CTCF and cohesin binding
title_full	Nucleoporin 153 links nuclear pore complex to chromatin architecture by mediating CTCF and cohesin binding
title_fullStr	Nucleoporin 153 links nuclear pore complex to chromatin architecture by mediating CTCF and cohesin binding
title_full_unstemmed	Nucleoporin 153 links nuclear pore complex to chromatin architecture by mediating CTCF and cohesin binding
title_sort	nucleoporin 153 links nuclear pore complex to chromatin architecture by mediating ctcf and cohesin binding
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/4648e84dd657468790c7182b423f1e5e
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Nucleoporin 153 links nuclear pore complex to chromatin architecture by mediating CTCF and cohesin binding

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