Nucleoporin 153 links nuclear pore complex to chromatin architecture by mediating CTCF and cohesin binding

Nucleoporin 153 links nuclear pore complex to chromatin architecture by mediating CTCF and cohesin binding

The nuclear pore complex components, nucleoporins, have been proposed to mediate spatial and temporal organization of chromatin. Here, the authors show that Nucleoporin 153 interacts with CTCF and cohesin, and mediates their binding across cis-regulatory elements and TAD boundaries in mouse embryoni...

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Autores principales: Shinichi Kadota, Jianhong Ou, Yuming Shi, Jeannie T. Lee, Jiayu Sun, Eda Yildirim
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/4648e84dd657468790c7182b423f1e5e
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