Preoperative intravitreal Ranibizumab with panretinal photocoagulation followed by conventional trabeculectomy without drainage device for neovascular glaucoma

AIM: To evaluate the efficacy and safety of preoperative intravitreal injection of ranibizumab(IVR)and panretinal photocoagulation(PRP)combined with conventional trabeculectomy without drainage device in patients with neovascular glaucoma(NVG).METHODS: The charts of 27 patients(27 eyes)who presented...

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Autores principales:	Xiao-Dong Han, Li Meng, Xiao-Jin Chen, Zhan-Jun Yan, Ke-Wei Song
Formato:	article
Lenguaje:	EN
Publicado:	Press of International Journal of Ophthalmology (IJO PRESS) 2021
Materias:	neovascular glaucoma ranibizumab panretinal photocoagulation trabeculectomy Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/464d0a25ec7d49b2a270879895862748
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spelling	oai:doaj.org-article:464d0a25ec7d49b2a2708798958627482021-11-22T14:22:32ZPreoperative intravitreal Ranibizumab with panretinal photocoagulation followed by conventional trabeculectomy without drainage device for neovascular glaucoma1672-512310.3980/j.issn.1672-5123.2021.12.02https://doaj.org/article/464d0a25ec7d49b2a2708798958627482021-12-01T00:00:00Zhttp://ies.ijo.cn/cn_publish/2021/12/202112002.pdfhttps://doaj.org/toc/1672-5123AIM: To evaluate the efficacy and safety of preoperative intravitreal injection of ranibizumab(IVR)and panretinal photocoagulation(PRP)combined with conventional trabeculectomy without drainage device in patients with neovascular glaucoma(NVG).METHODS: The charts of 27 patients(27 eyes)who presented with NVG in our hospital between August 2015 and November 2018 were reviewed. All eyes were treated using the standard protocol of IVR accompanied by PRP, followed by conventional trabeculectomy without drainage device. The main outcomes were intraocular pressure(IOP)control, change in best-corrected visual acuity(BCVA), and surgical complications.RESULTS: The postoperative follow-up periods for all patients were at least 18(mean 21.7±4.3)mo. The IOP significantly decreased from 45.7±5.1 mmHg(baseline)to 18.4±3.6 mmHg(last visit), and BCVA(LogMAR)improved from 2.42±0.68(baseline)to 1.77±0.93(last visit). The success rate was higher in eyes with peripheral anterior synechiae(PAS)≤50% than in those with PAS >50% after 3mo postoperatively. The main surgical complications were hyphema(11.1%)and hypotony with a shallow anterior chamber(14.8%)during the early postoperative stage, along with encapsulated bleb(37.0%)during the mid-late postoperative stage. Serious intraoperative or postoperative complications were not observed.CONCLUSION: IVR and PRP combined with conventional trabeculectomy without drainage device is a safe and effective way in NVG treatment, especially for eyes with PAS ≤50%. Preoperative IVR and PRP appear to improve the success rate.Xiao-Dong HanLi MengXiao-Jin ChenZhan-Jun YanKe-Wei SongPress of International Journal of Ophthalmology (IJO PRESS)articleneovascular glaucomaranibizumabpanretinal photocoagulationtrabeculectomyOphthalmologyRE1-994ENGuoji Yanke Zazhi, Vol 21, Iss 12, Pp 2026-2031 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	neovascular glaucoma ranibizumab panretinal photocoagulation trabeculectomy Ophthalmology RE1-994
spellingShingle	neovascular glaucoma ranibizumab panretinal photocoagulation trabeculectomy Ophthalmology RE1-994 Xiao-Dong Han Li Meng Xiao-Jin Chen Zhan-Jun Yan Ke-Wei Song Preoperative intravitreal Ranibizumab with panretinal photocoagulation followed by conventional trabeculectomy without drainage device for neovascular glaucoma
description	AIM: To evaluate the efficacy and safety of preoperative intravitreal injection of ranibizumab(IVR)and panretinal photocoagulation(PRP)combined with conventional trabeculectomy without drainage device in patients with neovascular glaucoma(NVG).METHODS: The charts of 27 patients(27 eyes)who presented with NVG in our hospital between August 2015 and November 2018 were reviewed. All eyes were treated using the standard protocol of IVR accompanied by PRP, followed by conventional trabeculectomy without drainage device. The main outcomes were intraocular pressure(IOP)control, change in best-corrected visual acuity(BCVA), and surgical complications.RESULTS: The postoperative follow-up periods for all patients were at least 18(mean 21.7±4.3)mo. The IOP significantly decreased from 45.7±5.1 mmHg(baseline)to 18.4±3.6 mmHg(last visit), and BCVA(LogMAR)improved from 2.42±0.68(baseline)to 1.77±0.93(last visit). The success rate was higher in eyes with peripheral anterior synechiae(PAS)≤50% than in those with PAS >50% after 3mo postoperatively. The main surgical complications were hyphema(11.1%)and hypotony with a shallow anterior chamber(14.8%)during the early postoperative stage, along with encapsulated bleb(37.0%)during the mid-late postoperative stage. Serious intraoperative or postoperative complications were not observed.CONCLUSION: IVR and PRP combined with conventional trabeculectomy without drainage device is a safe and effective way in NVG treatment, especially for eyes with PAS ≤50%. Preoperative IVR and PRP appear to improve the success rate.
format	article
author	Xiao-Dong Han Li Meng Xiao-Jin Chen Zhan-Jun Yan Ke-Wei Song
author_facet	Xiao-Dong Han Li Meng Xiao-Jin Chen Zhan-Jun Yan Ke-Wei Song
author_sort	Xiao-Dong Han
title	Preoperative intravitreal Ranibizumab with panretinal photocoagulation followed by conventional trabeculectomy without drainage device for neovascular glaucoma
title_short	Preoperative intravitreal Ranibizumab with panretinal photocoagulation followed by conventional trabeculectomy without drainage device for neovascular glaucoma
title_full	Preoperative intravitreal Ranibizumab with panretinal photocoagulation followed by conventional trabeculectomy without drainage device for neovascular glaucoma
title_fullStr	Preoperative intravitreal Ranibizumab with panretinal photocoagulation followed by conventional trabeculectomy without drainage device for neovascular glaucoma
title_full_unstemmed	Preoperative intravitreal Ranibizumab with panretinal photocoagulation followed by conventional trabeculectomy without drainage device for neovascular glaucoma
title_sort	preoperative intravitreal ranibizumab with panretinal photocoagulation followed by conventional trabeculectomy without drainage device for neovascular glaucoma
publisher	Press of International Journal of Ophthalmology (IJO PRESS)
publishDate	2021
url	https://doaj.org/article/464d0a25ec7d49b2a270879895862748
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Preoperative intravitreal Ranibizumab with panretinal photocoagulation followed by conventional trabeculectomy without drainage device for neovascular glaucoma

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