Hyponatremia as an Inflammatory Marker of Lupus Activity Is a Fact or Fad: A Cross-Sectional Study

Ahmed Yamany, Mervat E Behiry, Sahar A Ahmed Faculty of Medicine, Cairo University, Cairo, EgyptCorrespondence: Mervat E Behiry Tel +20 1124205071Fax +20 26 28 884Email lambaa2020@yahoo.comPurpose: Systemic lupus erythematosus (SLE) is an autoimmune disease with multi-organ involvement. Hyponatremia...

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Autores principales:	Yamany A, Behiry ME, Ahmed SA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	lupus erythematosus activity hyponatremia complement inflammation Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/464f5877807f4f5b9936984fb90ca218
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spelling	oai:doaj.org-article:464f5877807f4f5b9936984fb90ca2182021-12-02T09:03:26ZHyponatremia as an Inflammatory Marker of Lupus Activity Is a Fact or Fad: A Cross-Sectional Study1179-156Xhttps://doaj.org/article/464f5877807f4f5b9936984fb90ca2182020-03-01T00:00:00Zhttps://www.dovepress.com/hyponatremia-as-an-inflammatory-marker-of-lupus-activity-is-a-fact-or--peer-reviewed-article-OARRRhttps://doaj.org/toc/1179-156XAhmed Yamany, Mervat E Behiry, Sahar A Ahmed Faculty of Medicine, Cairo University, Cairo, EgyptCorrespondence: Mervat E Behiry Tel +20 1124205071Fax +20 26 28 884Email lambaa2020@yahoo.comPurpose: Systemic lupus erythematosus (SLE) is an autoimmune disease with multi-organ involvement. Hyponatremia is common in inflammatory diseases such as meningitis. Also, it has been found to be strongly associated with the degree of inflammation. However, it has not been fully evaluated in lupus. This study aimed to assess the inflammatory impact of hyponatremia in SLE patients and investigate its relationship with SLE disease activity.Patients and Methods: A total of  101 patients with SLE were enrolled in this study and divided into two groups according to Na level; a normo-natremic group and a hyponatremic group. Demographic and clinical data were collected. SLE activity was assessed by the systemic lupus erythematosus disease activity index (SLEDAI). The estimated sedimentation rate (ESR) as well as levels of C-reactive protein (CRP) and complements (C3 and C4) were measured.Results: The majority of patients were females (98 subjects) (97%) with a mean age of 33± 8 years. Out of 101 participants, 40 patients (39.6%) were hyponatremic with a mean Na level of 131.58± 3.11 mmol/L. There was a statistically negative correlation between both ESR and SLEADI score and Na level (r=− 0.436 and − 0.436, respectively) with p=0.002, whereas Na level was positively correlated with complements, Cl, and albumin levels (r=0.653, 0.314, and 0.460, respectively) (p=0.000, 0.027, and > 0.001, respectively). CRP was not correlated with Na level. ESR was independently correlated with hyponatremia at the 95% CI for Exp B (0.997– 0.058) with a p-value of 0.048.Conclusion: Hyponatremia could be used as an indicator of SLE activity. Also, it might be an easily and rapidly detected as well as a prognostically useful marker of inflammation.Keywords: lupus erythematosus, activity, hyponatremia, complement, inflammationYamany ABehiry MEAhmed SADove Medical Pressarticlelupus erythematosusactivityhyponatremiacomplementinflammationDiseases of the musculoskeletal systemRC925-935ENOpen Access Rheumatology: Research and Reviews, Vol Volume 12, Pp 29-34 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	lupus erythematosus activity hyponatremia complement inflammation Diseases of the musculoskeletal system RC925-935
spellingShingle	lupus erythematosus activity hyponatremia complement inflammation Diseases of the musculoskeletal system RC925-935 Yamany A Behiry ME Ahmed SA Hyponatremia as an Inflammatory Marker of Lupus Activity Is a Fact or Fad: A Cross-Sectional Study
description	Ahmed Yamany, Mervat E Behiry, Sahar A Ahmed Faculty of Medicine, Cairo University, Cairo, EgyptCorrespondence: Mervat E Behiry Tel +20 1124205071Fax +20 26 28 884Email lambaa2020@yahoo.comPurpose: Systemic lupus erythematosus (SLE) is an autoimmune disease with multi-organ involvement. Hyponatremia is common in inflammatory diseases such as meningitis. Also, it has been found to be strongly associated with the degree of inflammation. However, it has not been fully evaluated in lupus. This study aimed to assess the inflammatory impact of hyponatremia in SLE patients and investigate its relationship with SLE disease activity.Patients and Methods: A total of  101 patients with SLE were enrolled in this study and divided into two groups according to Na level; a normo-natremic group and a hyponatremic group. Demographic and clinical data were collected. SLE activity was assessed by the systemic lupus erythematosus disease activity index (SLEDAI). The estimated sedimentation rate (ESR) as well as levels of C-reactive protein (CRP) and complements (C3 and C4) were measured.Results: The majority of patients were females (98 subjects) (97%) with a mean age of 33± 8 years. Out of 101 participants, 40 patients (39.6%) were hyponatremic with a mean Na level of 131.58± 3.11 mmol/L. There was a statistically negative correlation between both ESR and SLEADI score and Na level (r=− 0.436 and − 0.436, respectively) with p=0.002, whereas Na level was positively correlated with complements, Cl, and albumin levels (r=0.653, 0.314, and 0.460, respectively) (p=0.000, 0.027, and > 0.001, respectively). CRP was not correlated with Na level. ESR was independently correlated with hyponatremia at the 95% CI for Exp B (0.997– 0.058) with a p-value of 0.048.Conclusion: Hyponatremia could be used as an indicator of SLE activity. Also, it might be an easily and rapidly detected as well as a prognostically useful marker of inflammation.Keywords: lupus erythematosus, activity, hyponatremia, complement, inflammation
format	article
author	Yamany A Behiry ME Ahmed SA
author_facet	Yamany A Behiry ME Ahmed SA
author_sort	Yamany A
title	Hyponatremia as an Inflammatory Marker of Lupus Activity Is a Fact or Fad: A Cross-Sectional Study
title_short	Hyponatremia as an Inflammatory Marker of Lupus Activity Is a Fact or Fad: A Cross-Sectional Study
title_full	Hyponatremia as an Inflammatory Marker of Lupus Activity Is a Fact or Fad: A Cross-Sectional Study
title_fullStr	Hyponatremia as an Inflammatory Marker of Lupus Activity Is a Fact or Fad: A Cross-Sectional Study
title_full_unstemmed	Hyponatremia as an Inflammatory Marker of Lupus Activity Is a Fact or Fad: A Cross-Sectional Study
title_sort	hyponatremia as an inflammatory marker of lupus activity is a fact or fad: a cross-sectional study
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/464f5877807f4f5b9936984fb90ca218
work_keys_str_mv	AT yamanya hyponatremiaasaninflammatorymarkeroflupusactivityisafactorfadacrosssectionalstudy AT behiryme hyponatremiaasaninflammatorymarkeroflupusactivityisafactorfadacrosssectionalstudy AT ahmedsa hyponatremiaasaninflammatorymarkeroflupusactivityisafactorfadacrosssectionalstudy
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Hyponatremia as an Inflammatory Marker of Lupus Activity Is a Fact or Fad: A Cross-Sectional Study

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