Hypoxia Regulates Endogenous Double-Stranded RNA Production via Reduced Mitochondrial DNA Transcription
Hypoxia is a common phenomenon in solid tumours strongly linked to the hallmarks of cancer. Hypoxia promotes local immunosuppression and downregulates type I interferon (IFN) expression and signalling, which contribute to the success of many cancer therapies. Double-stranded RNA (dsRNA), transiently...
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Autores principales: | Esther Arnaiz, Ana Miar, Antonio Gregorio Dias Junior, Naveen Prasad, Ulrike Schulze, Dominic Waithe, James A. Nathan, Jan Rehwinkel, Adrian L. Harris |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://doaj.org/article/4651a3ea482c498db9341a48c3118d06 |
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