Hypoxia Regulates Endogenous Double-Stranded RNA Production via Reduced Mitochondrial DNA Transcription

Hypoxia is a common phenomenon in solid tumours strongly linked to the hallmarks of cancer. Hypoxia promotes local immunosuppression and downregulates type I interferon (IFN) expression and signalling, which contribute to the success of many cancer therapies. Double-stranded RNA (dsRNA), transiently...

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Autores principales: Esther Arnaiz, Ana Miar, Antonio Gregorio Dias Junior, Naveen Prasad, Ulrike Schulze, Dominic Waithe, James A. Nathan, Jan Rehwinkel, Adrian L. Harris
Formato: article
Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
Materias:
IFN
Acceso en línea:https://doaj.org/article/4651a3ea482c498db9341a48c3118d06
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