YY1 inhibits differentiation and function of regulatory T cells by blocking Foxp3 expression and activity

Treg control the magnitude of immune responses, but how these cells are controlled is less understood. Here the authors show that a transcriptional repressor YY1 inhibits Foxp3, the master regulator of Treg, by repressing its transcription, and by directly interacting with Foxp3 and its target gene...

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Autores principales:	Soo Seok Hwang, Sung Woong Jang, Min Kyung Kim, Lark Kyun Kim, Bong-Sung Kim, Hyeong Su Kim, Kiwan Kim, Wonyong Lee, Richard A. Flavell, Gap Ryol Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4652ebf99d2c460eaee2534aba5dd274
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spelling	oai:doaj.org-article:4652ebf99d2c460eaee2534aba5dd2742021-12-02T16:50:15ZYY1 inhibits differentiation and function of regulatory T cells by blocking Foxp3 expression and activity10.1038/ncomms107892041-1723https://doaj.org/article/4652ebf99d2c460eaee2534aba5dd2742016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10789https://doaj.org/toc/2041-1723Treg control the magnitude of immune responses, but how these cells are controlled is less understood. Here the authors show that a transcriptional repressor YY1 inhibits Foxp3, the master regulator of Treg, by repressing its transcription, and by directly interacting with Foxp3 and its target gene promoters.Soo Seok HwangSung Woong JangMin Kyung KimLark Kyun KimBong-Sung KimHyeong Su KimKiwan KimWonyong LeeRichard A. FlavellGap Ryol LeeNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Soo Seok Hwang Sung Woong Jang Min Kyung Kim Lark Kyun Kim Bong-Sung Kim Hyeong Su Kim Kiwan Kim Wonyong Lee Richard A. Flavell Gap Ryol Lee YY1 inhibits differentiation and function of regulatory T cells by blocking Foxp3 expression and activity
description	Treg control the magnitude of immune responses, but how these cells are controlled is less understood. Here the authors show that a transcriptional repressor YY1 inhibits Foxp3, the master regulator of Treg, by repressing its transcription, and by directly interacting with Foxp3 and its target gene promoters.
format	article
author	Soo Seok Hwang Sung Woong Jang Min Kyung Kim Lark Kyun Kim Bong-Sung Kim Hyeong Su Kim Kiwan Kim Wonyong Lee Richard A. Flavell Gap Ryol Lee
author_facet	Soo Seok Hwang Sung Woong Jang Min Kyung Kim Lark Kyun Kim Bong-Sung Kim Hyeong Su Kim Kiwan Kim Wonyong Lee Richard A. Flavell Gap Ryol Lee
author_sort	Soo Seok Hwang
title	YY1 inhibits differentiation and function of regulatory T cells by blocking Foxp3 expression and activity
title_short	YY1 inhibits differentiation and function of regulatory T cells by blocking Foxp3 expression and activity
title_full	YY1 inhibits differentiation and function of regulatory T cells by blocking Foxp3 expression and activity
title_fullStr	YY1 inhibits differentiation and function of regulatory T cells by blocking Foxp3 expression and activity
title_full_unstemmed	YY1 inhibits differentiation and function of regulatory T cells by blocking Foxp3 expression and activity
title_sort	yy1 inhibits differentiation and function of regulatory t cells by blocking foxp3 expression and activity
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/4652ebf99d2c460eaee2534aba5dd274
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YY1 inhibits differentiation and function of regulatory T cells by blocking Foxp3 expression and activity

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