YY1 inhibits differentiation and function of regulatory T cells by blocking Foxp3 expression and activity

Treg control the magnitude of immune responses, but how these cells are controlled is less understood. Here the authors show that a transcriptional repressor YY1 inhibits Foxp3, the master regulator of Treg, by repressing its transcription, and by directly interacting with Foxp3 and its target gene...

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Autores principales: Soo Seok Hwang, Sung Woong Jang, Min Kyung Kim, Lark Kyun Kim, Bong-Sung Kim, Hyeong Su Kim, Kiwan Kim, Wonyong Lee, Richard A. Flavell, Gap Ryol Lee
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/4652ebf99d2c460eaee2534aba5dd274
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