In vivo generation of collagen specific Tregs with AAV8 suppresses autoimmune responses and arthritis in DBA1 mice through IL10 production

Abstract Available therapeutics for autoimmune disorders focused on mitigating symptoms, rather than treating the cause of the disorder. A novel approach using adeno-associated virus (AAV) could restore tolerance to the autoimmune targets and provide a permanent treatment for autoimmune diseases. He...

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Bibliographic Details
Main Authors: Matthew Wade, Hugues Fausther-Bovendo, Marc-Antoine De La Vega, Gary Kobinger
Format: article
Language:EN
Published: Nature Portfolio 2021
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Online Access:https://doaj.org/article/46587e0ae2a64831ab66f65f12b4a139
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