Role of asymptomatic hyperuricemia in the progression of chronic kidney disease and cardiovascular disease
Previous research has investigated whether hyperuricemia serves as an independent risk factor for cardiovascular and renal diseases. Hyperuricemia is defined as an abnormally high level of uric acid (UA; i.e., serum urate level > 6.8 mg/dL). Hyperuricemia has been considered a complication of chr...
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The Korean Association of Internal Medicine
2021
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oai:doaj.org-article:4659d27a97d14ffe88cb6214f90f65dc2021-11-08T00:59:06ZRole of asymptomatic hyperuricemia in the progression of chronic kidney disease and cardiovascular disease1226-33032005-664810.3904/kjim.2020.340https://doaj.org/article/4659d27a97d14ffe88cb6214f90f65dc2021-11-01T00:00:00Zhttp://www.kjim.org/upload/pdf/kjim-2020-340.pdfhttps://doaj.org/toc/1226-3303https://doaj.org/toc/2005-6648Previous research has investigated whether hyperuricemia serves as an independent risk factor for cardiovascular and renal diseases. Hyperuricemia is defined as an abnormally high level of uric acid (UA; i.e., serum urate level > 6.8 mg/dL). Hyperuricemia has been considered a complication of chronic kidney disease (CKD). However, it seems to play a pathogenic role in the progression of renal diseases. There has been increasing focus on the link between hyperuricemia and CKD. The results of randomized controlled trials have implied independent associations between hyperuricemia and the progression of cardiovascular and renal morbidities. These associations may be mediated by renin-angiotensin system activation, nitric oxide synthase inhibition, and macrovascular/microvascular disease development. There remains controversy regarding the use of serum UA level as an indirect index of renal vascular disease. This literature review focuses on the role of asymptomatic hyperuricemia in the progression of CKD, as well as the association between hyperuricemia and cardiovascular disease. It also provides a general overview of the physiological metabolism of UA.Yousuf WaheedFan YangDong SunThe Korean Association of Internal Medicinearticlehyperuricemiaxanthine oxidasefebuxostatcardiovascular diseaseschronic kidney diseaseMedicineRENThe Korean Journal of Internal Medicine, Vol 36, Iss 6, Pp 1281-1293 (2021) |
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DOAJ |
| collection |
DOAJ |
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EN |
| topic |
hyperuricemia xanthine oxidase febuxostat cardiovascular diseases chronic kidney disease Medicine R |
| spellingShingle |
hyperuricemia xanthine oxidase febuxostat cardiovascular diseases chronic kidney disease Medicine R Yousuf Waheed Fan Yang Dong Sun Role of asymptomatic hyperuricemia in the progression of chronic kidney disease and cardiovascular disease |
| description |
Previous research has investigated whether hyperuricemia serves as an independent risk factor for cardiovascular and renal diseases. Hyperuricemia is defined as an abnormally high level of uric acid (UA; i.e., serum urate level > 6.8 mg/dL). Hyperuricemia has been considered a complication of chronic kidney disease (CKD). However, it seems to play a pathogenic role in the progression of renal diseases. There has been increasing focus on the link between hyperuricemia and CKD. The results of randomized controlled trials have implied independent associations between hyperuricemia and the progression of cardiovascular and renal morbidities. These associations may be mediated by renin-angiotensin system activation, nitric oxide synthase inhibition, and macrovascular/microvascular disease development. There remains controversy regarding the use of serum UA level as an indirect index of renal vascular disease. This literature review focuses on the role of asymptomatic hyperuricemia in the progression of CKD, as well as the association between hyperuricemia and cardiovascular disease. It also provides a general overview of the physiological metabolism of UA. |
| format |
article |
| author |
Yousuf Waheed Fan Yang Dong Sun |
| author_facet |
Yousuf Waheed Fan Yang Dong Sun |
| author_sort |
Yousuf Waheed |
| title |
Role of asymptomatic hyperuricemia in the progression of chronic kidney disease and cardiovascular disease |
| title_short |
Role of asymptomatic hyperuricemia in the progression of chronic kidney disease and cardiovascular disease |
| title_full |
Role of asymptomatic hyperuricemia in the progression of chronic kidney disease and cardiovascular disease |
| title_fullStr |
Role of asymptomatic hyperuricemia in the progression of chronic kidney disease and cardiovascular disease |
| title_full_unstemmed |
Role of asymptomatic hyperuricemia in the progression of chronic kidney disease and cardiovascular disease |
| title_sort |
role of asymptomatic hyperuricemia in the progression of chronic kidney disease and cardiovascular disease |
| publisher |
The Korean Association of Internal Medicine |
| publishDate |
2021 |
| url |
https://doaj.org/article/4659d27a97d14ffe88cb6214f90f65dc |
| work_keys_str_mv |
AT yousufwaheed roleofasymptomatichyperuricemiaintheprogressionofchronickidneydiseaseandcardiovasculardisease AT fanyang roleofasymptomatichyperuricemiaintheprogressionofchronickidneydiseaseandcardiovasculardisease AT dongsun roleofasymptomatichyperuricemiaintheprogressionofchronickidneydiseaseandcardiovasculardisease |
| _version_ |
1718443276001869824 |