The mycobacterial phosphatase PtpA regulates the expression of host genes and promotes cell proliferation

Mycobacterium tuberculosis secretes a protein, PtpA, that dephosphorylates proteins in the host cell cytoplasm, weakening immune responses. Here, the authors show that PtpA also enters the nucleus, affects the expression of several host genes, and promotes proliferation and migration of a cancer cel...

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Autores principales:	Jing Wang, Pupu Ge, Lihua Qiang, Feng Tian, Dongdong Zhao, Qiyao Chai, Mingzhao Zhu, Rongbin Zhou, Guangxun Meng, Yoichiro Iwakura, George Fu Gao, Cui Hua Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/465a63bc5e6745cab574ea4a454e9961
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:465a63bc5e6745cab574ea4a454e99612021-12-02T13:24:14ZThe mycobacterial phosphatase PtpA regulates the expression of host genes and promotes cell proliferation10.1038/s41467-017-00279-z2041-1723https://doaj.org/article/465a63bc5e6745cab574ea4a454e99612017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00279-zhttps://doaj.org/toc/2041-1723Mycobacterium tuberculosis secretes a protein, PtpA, that dephosphorylates proteins in the host cell cytoplasm, weakening immune responses. Here, the authors show that PtpA also enters the nucleus, affects the expression of several host genes, and promotes proliferation and migration of a cancer cell line.Jing WangPupu GeLihua QiangFeng TianDongdong ZhaoQiyao ChaiMingzhao ZhuRongbin ZhouGuangxun MengYoichiro IwakuraGeorge Fu GaoCui Hua LiuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jing Wang Pupu Ge Lihua Qiang Feng Tian Dongdong Zhao Qiyao Chai Mingzhao Zhu Rongbin Zhou Guangxun Meng Yoichiro Iwakura George Fu Gao Cui Hua Liu The mycobacterial phosphatase PtpA regulates the expression of host genes and promotes cell proliferation
description	Mycobacterium tuberculosis secretes a protein, PtpA, that dephosphorylates proteins in the host cell cytoplasm, weakening immune responses. Here, the authors show that PtpA also enters the nucleus, affects the expression of several host genes, and promotes proliferation and migration of a cancer cell line.
format	article
author	Jing Wang Pupu Ge Lihua Qiang Feng Tian Dongdong Zhao Qiyao Chai Mingzhao Zhu Rongbin Zhou Guangxun Meng Yoichiro Iwakura George Fu Gao Cui Hua Liu
author_facet	Jing Wang Pupu Ge Lihua Qiang Feng Tian Dongdong Zhao Qiyao Chai Mingzhao Zhu Rongbin Zhou Guangxun Meng Yoichiro Iwakura George Fu Gao Cui Hua Liu
author_sort	Jing Wang
title	The mycobacterial phosphatase PtpA regulates the expression of host genes and promotes cell proliferation
title_short	The mycobacterial phosphatase PtpA regulates the expression of host genes and promotes cell proliferation
title_full	The mycobacterial phosphatase PtpA regulates the expression of host genes and promotes cell proliferation
title_fullStr	The mycobacterial phosphatase PtpA regulates the expression of host genes and promotes cell proliferation
title_full_unstemmed	The mycobacterial phosphatase PtpA regulates the expression of host genes and promotes cell proliferation
title_sort	mycobacterial phosphatase ptpa regulates the expression of host genes and promotes cell proliferation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/465a63bc5e6745cab574ea4a454e9961
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The mycobacterial phosphatase PtpA regulates the expression of host genes and promotes cell proliferation

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