The mycobacterial phosphatase PtpA regulates the expression of host genes and promotes cell proliferation
Mycobacterium tuberculosis secretes a protein, PtpA, that dephosphorylates proteins in the host cell cytoplasm, weakening immune responses. Here, the authors show that PtpA also enters the nucleus, affects the expression of several host genes, and promotes proliferation and migration of a cancer cel...
Guardado en:
Autores principales: | Jing Wang, Pupu Ge, Lihua Qiang, Feng Tian, Dongdong Zhao, Qiyao Chai, Mingzhao Zhu, Rongbin Zhou, Guangxun Meng, Yoichiro Iwakura, George Fu Gao, Cui Hua Liu |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2017
|
Materias: | |
Acceso en línea: | https://doaj.org/article/465a63bc5e6745cab574ea4a454e9961 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
PtpA and PknG Proteins Secreted by Mycobacterium avium subsp. paratuberculosis are Recognized by Sera from Patients with Rheumatoid Arthritis: A Case–Control Study
por: Bo M, et al.
Publicado: (2019) -
Protein tyrosine phosphatase µ (PTP µ or PTPRM), a negative regulator of proliferation and invasion of breast cancer cells, is associated with disease prognosis.
por: Ping-Hui Sun, et al.
Publicado: (2012) -
Involvement of protein tyrosine phosphatases BcPtpA and BcPtpB in regulation of vegetative development, virulence and multi-stress tolerance in Botrytis cinerea.
por: Qianqian Yang, et al.
Publicado: (2013) -
The open architecture of HD-PTP phosphatase provides new insights into the mechanism of regulation of ESCRT function
por: Deepankar Gahloth, et al.
Publicado: (2017) -
A Mycobacterium tuberculosis surface protein recruits ubiquitin to trigger host xenophagy
por: Qiyao Chai, et al.
Publicado: (2019)