The corticospinal tract primarily modulates sensory inputs in the mouse lumbar cord

It is generally assumed that the main function of the corticospinal tract (CST) is to convey motor commands to bulbar or spinal motoneurons. Yet the CST has also been shown to modulate sensory signals at their entry point in the spinal cord through primary afferent depolarization (PAD). By sequentia...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yunuen Moreno-Lopez, Charlotte Bichara, Gilles Delbecq, Philippe Isope, Matilde Cordero-Erausquin
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	corticospinal sensorimotor primary afferent depolarization Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/465e5974e11d42ed89de5c507e9122f1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:465e5974e11d42ed89de5c507e9122f1
record_format	dspace
spelling	oai:doaj.org-article:465e5974e11d42ed89de5c507e9122f12021-11-15T07:20:32ZThe corticospinal tract primarily modulates sensory inputs in the mouse lumbar cord10.7554/eLife.653042050-084Xe65304https://doaj.org/article/465e5974e11d42ed89de5c507e9122f12021-09-01T00:00:00Zhttps://elifesciences.org/articles/65304https://doaj.org/toc/2050-084XIt is generally assumed that the main function of the corticospinal tract (CST) is to convey motor commands to bulbar or spinal motoneurons. Yet the CST has also been shown to modulate sensory signals at their entry point in the spinal cord through primary afferent depolarization (PAD). By sequentially investigating different routes of corticofugal pathways through electrophysiological recordings and an intersectional viral strategy, we here demonstrate that motor and sensory modulation commands in mice belong to segregated paths within the CST. Sensory modulation is executed exclusively by the CST via a population of lumbar interneurons located in the deep dorsal horn. In contrast, the cortex conveys the motor command via a relay in the upper spinal cord or supraspinal motor centers. At lumbar level, the main role of the CST is thus the modulation of sensory inputs, which is an essential component of the selective tuning of sensory feedback used to ensure well-coordinated and skilled movement.Yunuen Moreno-LopezCharlotte BicharaGilles DelbecqPhilippe IsopeMatilde Cordero-ErausquineLife Sciences Publications Ltdarticlecorticospinalsensorimotorprimary afferent depolarizationMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	corticospinal sensorimotor primary afferent depolarization Medicine R Science Q Biology (General) QH301-705.5
spellingShingle	corticospinal sensorimotor primary afferent depolarization Medicine R Science Q Biology (General) QH301-705.5 Yunuen Moreno-Lopez Charlotte Bichara Gilles Delbecq Philippe Isope Matilde Cordero-Erausquin The corticospinal tract primarily modulates sensory inputs in the mouse lumbar cord
description	It is generally assumed that the main function of the corticospinal tract (CST) is to convey motor commands to bulbar or spinal motoneurons. Yet the CST has also been shown to modulate sensory signals at their entry point in the spinal cord through primary afferent depolarization (PAD). By sequentially investigating different routes of corticofugal pathways through electrophysiological recordings and an intersectional viral strategy, we here demonstrate that motor and sensory modulation commands in mice belong to segregated paths within the CST. Sensory modulation is executed exclusively by the CST via a population of lumbar interneurons located in the deep dorsal horn. In contrast, the cortex conveys the motor command via a relay in the upper spinal cord or supraspinal motor centers. At lumbar level, the main role of the CST is thus the modulation of sensory inputs, which is an essential component of the selective tuning of sensory feedback used to ensure well-coordinated and skilled movement.
format	article
author	Yunuen Moreno-Lopez Charlotte Bichara Gilles Delbecq Philippe Isope Matilde Cordero-Erausquin
author_facet	Yunuen Moreno-Lopez Charlotte Bichara Gilles Delbecq Philippe Isope Matilde Cordero-Erausquin
author_sort	Yunuen Moreno-Lopez
title	The corticospinal tract primarily modulates sensory inputs in the mouse lumbar cord
title_short	The corticospinal tract primarily modulates sensory inputs in the mouse lumbar cord
title_full	The corticospinal tract primarily modulates sensory inputs in the mouse lumbar cord
title_fullStr	The corticospinal tract primarily modulates sensory inputs in the mouse lumbar cord
title_full_unstemmed	The corticospinal tract primarily modulates sensory inputs in the mouse lumbar cord
title_sort	corticospinal tract primarily modulates sensory inputs in the mouse lumbar cord
publisher	eLife Sciences Publications Ltd
publishDate	2021
url	https://doaj.org/article/465e5974e11d42ed89de5c507e9122f1
work_keys_str_mv	AT yunuenmorenolopez thecorticospinaltractprimarilymodulatessensoryinputsinthemouselumbarcord AT charlottebichara thecorticospinaltractprimarilymodulatessensoryinputsinthemouselumbarcord AT gillesdelbecq thecorticospinaltractprimarilymodulatessensoryinputsinthemouselumbarcord AT philippeisope thecorticospinaltractprimarilymodulatessensoryinputsinthemouselumbarcord AT matildecorderoerausquin thecorticospinaltractprimarilymodulatessensoryinputsinthemouselumbarcord AT yunuenmorenolopez corticospinaltractprimarilymodulatessensoryinputsinthemouselumbarcord AT charlottebichara corticospinaltractprimarilymodulatessensoryinputsinthemouselumbarcord AT gillesdelbecq corticospinaltractprimarilymodulatessensoryinputsinthemouselumbarcord AT philippeisope corticospinaltractprimarilymodulatessensoryinputsinthemouselumbarcord AT matildecorderoerausquin corticospinaltractprimarilymodulatessensoryinputsinthemouselumbarcord
_version_	1718428491939053568

The corticospinal tract primarily modulates sensory inputs in the mouse lumbar cord

Ejemplares similares