Selective targeting of non-centrosomal AURKA functions through use of a targeted protein degradation tool

Wang et al develop tools to target the mitotic regulator AURKA by synthesising PROTACs based on the inhibitor MLN8237. They find that the new PROTAC compound efficiently clears cytoplasmic and mitotic spindle-associated AURKA but does not eliminate AURKA activity from centrosomes, demonstrating the...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Richard Wang, Camilla Ascanelli, Ahmed Abdelbaki, Alex Fung, Tim Rasmusson, Iacovos Michaelides, Karen Roberts, Catherine Lindon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/465f730a69b64dfb9fe0a36d0ac01429
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:465f730a69b64dfb9fe0a36d0ac01429
record_format	dspace
spelling	oai:doaj.org-article:465f730a69b64dfb9fe0a36d0ac014292021-12-02T15:49:50ZSelective targeting of non-centrosomal AURKA functions through use of a targeted protein degradation tool10.1038/s42003-021-02158-22399-3642https://doaj.org/article/465f730a69b64dfb9fe0a36d0ac014292021-05-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02158-2https://doaj.org/toc/2399-3642Wang et al develop tools to target the mitotic regulator AURKA by synthesising PROTACs based on the inhibitor MLN8237. They find that the new PROTAC compound efficiently clears cytoplasmic and mitotic spindle-associated AURKA but does not eliminate AURKA activity from centrosomes, demonstrating the possibility of targeting subpopulations.Richard WangCamilla AscanelliAhmed AbdelbakiAlex FungTim RasmussonIacovos MichaelidesKaren RobertsCatherine LindonNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Richard Wang Camilla Ascanelli Ahmed Abdelbaki Alex Fung Tim Rasmusson Iacovos Michaelides Karen Roberts Catherine Lindon Selective targeting of non-centrosomal AURKA functions through use of a targeted protein degradation tool
description	Wang et al develop tools to target the mitotic regulator AURKA by synthesising PROTACs based on the inhibitor MLN8237. They find that the new PROTAC compound efficiently clears cytoplasmic and mitotic spindle-associated AURKA but does not eliminate AURKA activity from centrosomes, demonstrating the possibility of targeting subpopulations.
format	article
author	Richard Wang Camilla Ascanelli Ahmed Abdelbaki Alex Fung Tim Rasmusson Iacovos Michaelides Karen Roberts Catherine Lindon
author_facet	Richard Wang Camilla Ascanelli Ahmed Abdelbaki Alex Fung Tim Rasmusson Iacovos Michaelides Karen Roberts Catherine Lindon
author_sort	Richard Wang
title	Selective targeting of non-centrosomal AURKA functions through use of a targeted protein degradation tool
title_short	Selective targeting of non-centrosomal AURKA functions through use of a targeted protein degradation tool
title_full	Selective targeting of non-centrosomal AURKA functions through use of a targeted protein degradation tool
title_fullStr	Selective targeting of non-centrosomal AURKA functions through use of a targeted protein degradation tool
title_full_unstemmed	Selective targeting of non-centrosomal AURKA functions through use of a targeted protein degradation tool
title_sort	selective targeting of non-centrosomal aurka functions through use of a targeted protein degradation tool
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/465f730a69b64dfb9fe0a36d0ac01429
work_keys_str_mv	AT richardwang selectivetargetingofnoncentrosomalaurkafunctionsthroughuseofatargetedproteindegradationtool AT camillaascanelli selectivetargetingofnoncentrosomalaurkafunctionsthroughuseofatargetedproteindegradationtool AT ahmedabdelbaki selectivetargetingofnoncentrosomalaurkafunctionsthroughuseofatargetedproteindegradationtool AT alexfung selectivetargetingofnoncentrosomalaurkafunctionsthroughuseofatargetedproteindegradationtool AT timrasmusson selectivetargetingofnoncentrosomalaurkafunctionsthroughuseofatargetedproteindegradationtool AT iacovosmichaelides selectivetargetingofnoncentrosomalaurkafunctionsthroughuseofatargetedproteindegradationtool AT karenroberts selectivetargetingofnoncentrosomalaurkafunctionsthroughuseofatargetedproteindegradationtool AT catherinelindon selectivetargetingofnoncentrosomalaurkafunctionsthroughuseofatargetedproteindegradationtool
_version_	1718385686324707328

Selective targeting of non-centrosomal AURKA functions through use of a targeted protein degradation tool

Ejemplares similares