Integrated pharmaco-proteogenomics defines two subgroups in isocitrate dehydrogenase wild-type glioblastoma with prognostic and therapeutic opportunities
The heterogeneity of IDH1/2 wild-type glioblastoma limits its prognosis and therapy. Here, the authors show a binary stratification, based on quantitative proteomic analysis of samples from patients with glioblastoma, with different prognosis and therapeutic vulnerabilities.
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Nature Portfolio
2020
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oai:doaj.org-article:4661a5f377d24eba844773750fa5ffeb2021-12-02T18:18:46ZIntegrated pharmaco-proteogenomics defines two subgroups in isocitrate dehydrogenase wild-type glioblastoma with prognostic and therapeutic opportunities10.1038/s41467-020-17139-y2041-1723https://doaj.org/article/4661a5f377d24eba844773750fa5ffeb2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17139-yhttps://doaj.org/toc/2041-1723The heterogeneity of IDH1/2 wild-type glioblastoma limits its prognosis and therapy. Here, the authors show a binary stratification, based on quantitative proteomic analysis of samples from patients with glioblastoma, with different prognosis and therapeutic vulnerabilities.Sejin OhJeonghun YeomHee Jin ChoJu-Hwa KimSeon-Jin YoonHakhyun KimJason K. SaShinyeong JuHwanho LeeMyung Joon OhWonyeop LeeYumi KwonHonglan LiSeunghyuk ChoiJang Hee HanJong Hee ChangEunsuk ChoiJayeon KimNam-Gu HerSe Hoon KimSeok-Gu KangEunok PaekDo-Hyun NamCheolju LeeHyun Seok KimNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020) |
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Science Q |
| spellingShingle |
Science Q Sejin Oh Jeonghun Yeom Hee Jin Cho Ju-Hwa Kim Seon-Jin Yoon Hakhyun Kim Jason K. Sa Shinyeong Ju Hwanho Lee Myung Joon Oh Wonyeop Lee Yumi Kwon Honglan Li Seunghyuk Choi Jang Hee Han Jong Hee Chang Eunsuk Choi Jayeon Kim Nam-Gu Her Se Hoon Kim Seok-Gu Kang Eunok Paek Do-Hyun Nam Cheolju Lee Hyun Seok Kim Integrated pharmaco-proteogenomics defines two subgroups in isocitrate dehydrogenase wild-type glioblastoma with prognostic and therapeutic opportunities |
| description |
The heterogeneity of IDH1/2 wild-type glioblastoma limits its prognosis and therapy. Here, the authors show a binary stratification, based on quantitative proteomic analysis of samples from patients with glioblastoma, with different prognosis and therapeutic vulnerabilities. |
| format |
article |
| author |
Sejin Oh Jeonghun Yeom Hee Jin Cho Ju-Hwa Kim Seon-Jin Yoon Hakhyun Kim Jason K. Sa Shinyeong Ju Hwanho Lee Myung Joon Oh Wonyeop Lee Yumi Kwon Honglan Li Seunghyuk Choi Jang Hee Han Jong Hee Chang Eunsuk Choi Jayeon Kim Nam-Gu Her Se Hoon Kim Seok-Gu Kang Eunok Paek Do-Hyun Nam Cheolju Lee Hyun Seok Kim |
| author_facet |
Sejin Oh Jeonghun Yeom Hee Jin Cho Ju-Hwa Kim Seon-Jin Yoon Hakhyun Kim Jason K. Sa Shinyeong Ju Hwanho Lee Myung Joon Oh Wonyeop Lee Yumi Kwon Honglan Li Seunghyuk Choi Jang Hee Han Jong Hee Chang Eunsuk Choi Jayeon Kim Nam-Gu Her Se Hoon Kim Seok-Gu Kang Eunok Paek Do-Hyun Nam Cheolju Lee Hyun Seok Kim |
| author_sort |
Sejin Oh |
| title |
Integrated pharmaco-proteogenomics defines two subgroups in isocitrate dehydrogenase wild-type glioblastoma with prognostic and therapeutic opportunities |
| title_short |
Integrated pharmaco-proteogenomics defines two subgroups in isocitrate dehydrogenase wild-type glioblastoma with prognostic and therapeutic opportunities |
| title_full |
Integrated pharmaco-proteogenomics defines two subgroups in isocitrate dehydrogenase wild-type glioblastoma with prognostic and therapeutic opportunities |
| title_fullStr |
Integrated pharmaco-proteogenomics defines two subgroups in isocitrate dehydrogenase wild-type glioblastoma with prognostic and therapeutic opportunities |
| title_full_unstemmed |
Integrated pharmaco-proteogenomics defines two subgroups in isocitrate dehydrogenase wild-type glioblastoma with prognostic and therapeutic opportunities |
| title_sort |
integrated pharmaco-proteogenomics defines two subgroups in isocitrate dehydrogenase wild-type glioblastoma with prognostic and therapeutic opportunities |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/4661a5f377d24eba844773750fa5ffeb |
| work_keys_str_mv |
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| _version_ |
1718378210783133696 |