Attitudes toward antipsychotic treatment among patients with bipolar disorders and their clinicians: a systematic review

Martha Sajatovic,1 Faith DiBiasi,2 Susan N Legacy3 1Departments of Psychiatry and Neurology, Case Western Reserve University School of Medicine, Cleveland, OH, USA; 2US Medical Affairs, Neuroscience, Otsuka Pharmaceutical Development & Commercialization, Inc., Rockville, MD, USA; 3US Medica...

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Autores principales:	Sajatovic M, DiBiasi F, Legacy SN
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	bipolar disorder antipsychotics systematic review attitudes Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/4664688c3ff14bc69b41b91838603b1c
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spelling	oai:doaj.org-article:4664688c3ff14bc69b41b91838603b1c2021-12-02T08:30:41ZAttitudes toward antipsychotic treatment among patients with bipolar disorders and their clinicians: a systematic review1178-2021https://doaj.org/article/4664688c3ff14bc69b41b91838603b1c2017-08-01T00:00:00Zhttps://www.dovepress.com/attitudes-toward-antipsychotic-treatment-among-patients-with-bipolar-d-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Martha Sajatovic,1 Faith DiBiasi,2 Susan N Legacy3 1Departments of Psychiatry and Neurology, Case Western Reserve University School of Medicine, Cleveland, OH, USA; 2US Medical Affairs, Neuroscience, Otsuka Pharmaceutical Development & Commercialization, Inc., Rockville, MD, USA; 3US Medical Affairs, Neuroscience, Otsuka Pharmaceutical Development & Commercialization, Inc., Princeton, NJ, USA Introduction: Antipsychotics are recommended as first-line therapy for acute mania and maintenance treatment of bipolar disorder; however, published literature suggests their real-world use remains limited. Understanding attitudes toward these medications may help identify barriers and inform personalized therapy. This literature review evaluated patient and clinician attitudes toward the use of antipsychotics for treating bipolar disorder. Materials and methods: A systematic search of the Cochrane Library, Ovid MEDLINE, Embase, and BIOSIS Previews identified English language articles published between January 1, 2000, and June 15, 2016, that reported attitudinal data from patients, health care professionals, or caregivers; treatment decision-making; or patient characteristics that predicted antipsychotic use for bipolar disorder. Results were analyzed descriptively. Results: Of the 209 references identified, 11 met the inclusion criteria and were evaluated. These articles provided attitudinal information from 1,418 patients with bipolar disorder and 1,282 treating clinicians. Patients’ attitudes toward antipsychotics were generally positive. Longer duration of clinical stability was associated with positive attitudes. Implementation of psychoeducational and adherence enhancement strategies could improve patient attitudes. Limited data suggest clinicians’ perceptions of antipsychotic efficacy and tolerability may have the greatest impact on their prescribing patterns. Because the current real-world evidence base is inadequate, clinician attitudes may reflect a relative lack of experience using antipsychotics in patients with bipolar disorder. Conclusion: Although data are very limited, perceived tolerability and efficacy concerns shape both patient and clinician attitudes toward use of antipsychotic drugs in bipolar disorder. Additional studies are warranted. Keywords: bipolar disorder, antipsychotics, systematic review, attitudesSajatovic MDiBiasi FLegacy SNDove Medical Pressarticlebipolar disorderantipsychoticssystematic reviewattitudesNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 2285-2296 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	bipolar disorder antipsychotics systematic review attitudes Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	bipolar disorder antipsychotics systematic review attitudes Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Sajatovic M DiBiasi F Legacy SN Attitudes toward antipsychotic treatment among patients with bipolar disorders and their clinicians: a systematic review
description	Martha Sajatovic,1 Faith DiBiasi,2 Susan N Legacy3 1Departments of Psychiatry and Neurology, Case Western Reserve University School of Medicine, Cleveland, OH, USA; 2US Medical Affairs, Neuroscience, Otsuka Pharmaceutical Development & Commercialization, Inc., Rockville, MD, USA; 3US Medical Affairs, Neuroscience, Otsuka Pharmaceutical Development & Commercialization, Inc., Princeton, NJ, USA Introduction: Antipsychotics are recommended as first-line therapy for acute mania and maintenance treatment of bipolar disorder; however, published literature suggests their real-world use remains limited. Understanding attitudes toward these medications may help identify barriers and inform personalized therapy. This literature review evaluated patient and clinician attitudes toward the use of antipsychotics for treating bipolar disorder. Materials and methods: A systematic search of the Cochrane Library, Ovid MEDLINE, Embase, and BIOSIS Previews identified English language articles published between January 1, 2000, and June 15, 2016, that reported attitudinal data from patients, health care professionals, or caregivers; treatment decision-making; or patient characteristics that predicted antipsychotic use for bipolar disorder. Results were analyzed descriptively. Results: Of the 209 references identified, 11 met the inclusion criteria and were evaluated. These articles provided attitudinal information from 1,418 patients with bipolar disorder and 1,282 treating clinicians. Patients’ attitudes toward antipsychotics were generally positive. Longer duration of clinical stability was associated with positive attitudes. Implementation of psychoeducational and adherence enhancement strategies could improve patient attitudes. Limited data suggest clinicians’ perceptions of antipsychotic efficacy and tolerability may have the greatest impact on their prescribing patterns. Because the current real-world evidence base is inadequate, clinician attitudes may reflect a relative lack of experience using antipsychotics in patients with bipolar disorder. Conclusion: Although data are very limited, perceived tolerability and efficacy concerns shape both patient and clinician attitudes toward use of antipsychotic drugs in bipolar disorder. Additional studies are warranted. Keywords: bipolar disorder, antipsychotics, systematic review, attitudes
format	article
author	Sajatovic M DiBiasi F Legacy SN
author_facet	Sajatovic M DiBiasi F Legacy SN
author_sort	Sajatovic M
title	Attitudes toward antipsychotic treatment among patients with bipolar disorders and their clinicians: a systematic review
title_short	Attitudes toward antipsychotic treatment among patients with bipolar disorders and their clinicians: a systematic review
title_full	Attitudes toward antipsychotic treatment among patients with bipolar disorders and their clinicians: a systematic review
title_fullStr	Attitudes toward antipsychotic treatment among patients with bipolar disorders and their clinicians: a systematic review
title_full_unstemmed	Attitudes toward antipsychotic treatment among patients with bipolar disorders and their clinicians: a systematic review
title_sort	attitudes toward antipsychotic treatment among patients with bipolar disorders and their clinicians: a systematic review
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/4664688c3ff14bc69b41b91838603b1c
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Attitudes toward antipsychotic treatment among patients with bipolar disorders and their clinicians: a systematic review

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