A CEP215–HSET complex links centrosomes with spindle poles and drives centrosome clustering in cancer

Centrosome clustering allows survival of cells with amplified centrosomes at the cost of chromosome instability. Here, Chavali et al. show that the centrosome component CEP215 collaborates with the kinesin motor HSET both to maintain spindle poles connections and to cluster centrosomes.

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Autores principales:	Pavithra L. Chavali, Gayathri Chandrasekaran, Alexis R. Barr, Péter Tátrai, Chris Taylor, Evaggelia K. Papachristou, C. Geoffrey Woods, Sreenivas Chavali, Fanni Gergely
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4664daf63d79423baf3e5927ce16113c
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spelling	oai:doaj.org-article:4664daf63d79423baf3e5927ce16113c2021-12-02T15:35:18ZA CEP215–HSET complex links centrosomes with spindle poles and drives centrosome clustering in cancer10.1038/ncomms110052041-1723https://doaj.org/article/4664daf63d79423baf3e5927ce16113c2016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms11005https://doaj.org/toc/2041-1723Centrosome clustering allows survival of cells with amplified centrosomes at the cost of chromosome instability. Here, Chavali et al. show that the centrosome component CEP215 collaborates with the kinesin motor HSET both to maintain spindle poles connections and to cluster centrosomes.Pavithra L. ChavaliGayathri ChandrasekaranAlexis R. BarrPéter TátraiChris TaylorEvaggelia K. PapachristouC. Geoffrey WoodsSreenivas ChavaliFanni GergelyNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pavithra L. Chavali Gayathri Chandrasekaran Alexis R. Barr Péter Tátrai Chris Taylor Evaggelia K. Papachristou C. Geoffrey Woods Sreenivas Chavali Fanni Gergely A CEP215–HSET complex links centrosomes with spindle poles and drives centrosome clustering in cancer
description	Centrosome clustering allows survival of cells with amplified centrosomes at the cost of chromosome instability. Here, Chavali et al. show that the centrosome component CEP215 collaborates with the kinesin motor HSET both to maintain spindle poles connections and to cluster centrosomes.
format	article
author	Pavithra L. Chavali Gayathri Chandrasekaran Alexis R. Barr Péter Tátrai Chris Taylor Evaggelia K. Papachristou C. Geoffrey Woods Sreenivas Chavali Fanni Gergely
author_facet	Pavithra L. Chavali Gayathri Chandrasekaran Alexis R. Barr Péter Tátrai Chris Taylor Evaggelia K. Papachristou C. Geoffrey Woods Sreenivas Chavali Fanni Gergely
author_sort	Pavithra L. Chavali
title	A CEP215–HSET complex links centrosomes with spindle poles and drives centrosome clustering in cancer
title_short	A CEP215–HSET complex links centrosomes with spindle poles and drives centrosome clustering in cancer
title_full	A CEP215–HSET complex links centrosomes with spindle poles and drives centrosome clustering in cancer
title_fullStr	A CEP215–HSET complex links centrosomes with spindle poles and drives centrosome clustering in cancer
title_full_unstemmed	A CEP215–HSET complex links centrosomes with spindle poles and drives centrosome clustering in cancer
title_sort	cep215–hset complex links centrosomes with spindle poles and drives centrosome clustering in cancer
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/4664daf63d79423baf3e5927ce16113c
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A CEP215–HSET complex links centrosomes with spindle poles and drives centrosome clustering in cancer

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