A CEP215–HSET complex links centrosomes with spindle poles and drives centrosome clustering in cancer

A CEP215–HSET complex links centrosomes with spindle poles and drives centrosome clustering in cancer

Centrosome clustering allows survival of cells with amplified centrosomes at the cost of chromosome instability. Here, Chavali et al. show that the centrosome component CEP215 collaborates with the kinesin motor HSET both to maintain spindle poles connections and to cluster centrosomes.

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Detalles Bibliográficos
Autores principales: Pavithra L. Chavali, Gayathri Chandrasekaran, Alexis R. Barr, Péter Tátrai, Chris Taylor, Evaggelia K. Papachristou, C. Geoffrey Woods, Sreenivas Chavali, Fanni Gergely
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/4664daf63d79423baf3e5927ce16113c
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