How EF-Tu can contribute to efficient proofreading of aa-tRNA by the ribosome

The translation of mRNA by the ribosome is governed by a series of large-scale conformational transitions. Here the authors use MD simulations to demonstrate how the rate of dissociation of elongation factor Tu affects the dynamics of tRNA accommodation and proofreading.

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Detalles Bibliográficos
Autores principales: Jeffrey K. Noel, Paul C. Whitford
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Q
Acceso en línea:https://doaj.org/article/4665a00df93a45c6bbfffb5f8957ae1c
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Sumario:The translation of mRNA by the ribosome is governed by a series of large-scale conformational transitions. Here the authors use MD simulations to demonstrate how the rate of dissociation of elongation factor Tu affects the dynamics of tRNA accommodation and proofreading.