How EF-Tu can contribute to efficient proofreading of aa-tRNA by the ribosome

The translation of mRNA by the ribosome is governed by a series of large-scale conformational transitions. Here the authors use MD simulations to demonstrate how the rate of dissociation of elongation factor Tu affects the dynamics of tRNA accommodation and proofreading.

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Detalles Bibliográficos
Autores principales:	Jeffrey K. Noel, Paul C. Whitford
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4665a00df93a45c6bbfffb5f8957ae1c
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spelling	oai:doaj.org-article:4665a00df93a45c6bbfffb5f8957ae1c2021-12-02T14:40:13ZHow EF-Tu can contribute to efficient proofreading of aa-tRNA by the ribosome10.1038/ncomms133142041-1723https://doaj.org/article/4665a00df93a45c6bbfffb5f8957ae1c2016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13314https://doaj.org/toc/2041-1723The translation of mRNA by the ribosome is governed by a series of large-scale conformational transitions. Here the authors use MD simulations to demonstrate how the rate of dissociation of elongation factor Tu affects the dynamics of tRNA accommodation and proofreading.Jeffrey K. NoelPaul C. WhitfordNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jeffrey K. Noel Paul C. Whitford How EF-Tu can contribute to efficient proofreading of aa-tRNA by the ribosome
description	The translation of mRNA by the ribosome is governed by a series of large-scale conformational transitions. Here the authors use MD simulations to demonstrate how the rate of dissociation of elongation factor Tu affects the dynamics of tRNA accommodation and proofreading.
format	article
author	Jeffrey K. Noel Paul C. Whitford
author_facet	Jeffrey K. Noel Paul C. Whitford
author_sort	Jeffrey K. Noel
title	How EF-Tu can contribute to efficient proofreading of aa-tRNA by the ribosome
title_short	How EF-Tu can contribute to efficient proofreading of aa-tRNA by the ribosome
title_full	How EF-Tu can contribute to efficient proofreading of aa-tRNA by the ribosome
title_fullStr	How EF-Tu can contribute to efficient proofreading of aa-tRNA by the ribosome
title_full_unstemmed	How EF-Tu can contribute to efficient proofreading of aa-tRNA by the ribosome
title_sort	how ef-tu can contribute to efficient proofreading of aa-trna by the ribosome
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/4665a00df93a45c6bbfffb5f8957ae1c
work_keys_str_mv	AT jeffreyknoel howeftucancontributetoefficientproofreadingofaatrnabytheribosome AT paulcwhitford howeftucancontributetoefficientproofreadingofaatrnabytheribosome
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How EF-Tu can contribute to efficient proofreading of aa-tRNA by the ribosome

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