How EF-Tu can contribute to efficient proofreading of aa-tRNA by the ribosome

The translation of mRNA by the ribosome is governed by a series of large-scale conformational transitions. Here the authors use MD simulations to demonstrate how the rate of dissociation of elongation factor Tu affects the dynamics of tRNA accommodation and proofreading.

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Bibliographic Details
Main Authors: Jeffrey K. Noel, Paul C. Whitford
Format: article
Language:EN
Published: Nature Portfolio 2016
Subjects:
Q
Online Access:https://doaj.org/article/4665a00df93a45c6bbfffb5f8957ae1c
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